Abstract：
:7-Chlorokynurenic acid (7-Cl KYNA) has been reported to attenuate N-methyl-D-aspartate (NMDA) receptor functioning by a potent and selective inhibitory action mediated at the strychnine-insensitive glycine recognition site of the NMDA complex. Here we report that 7-Cl KYNA dose-dependently inhibits [3H]MK-801 binding to the PCP receptor, and that this effect is reversed by addition of glycine. Since [3H]MK-801 binding is a measure of channel activation, our results are consistent with the hypotheses that 7-Cl KYNA exerts its NMDA receptor antagonism by acting at the glycine site, and that activation of the glycine site is required for NMDA channel activity to occur.
journal_name
Brain Resjournal_title
Brain researchauthors
Sircar R,Frusciante MJ,Javitt DC,Zukin SRdoi
10.1016/0006-8993(89)91378-4subject
Has Abstractpub_date
1989-12-18 00:00:00pages
325-7issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(89)91378-4journal_volume
504pub_type
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