Abstract：
:The pleiotropic cytokine tumor necrosis factor-alpha (TNFalpha) is implicated in the development of persistent pain through its actions in the periphery and in the central nervous system (CNS). Activation of the alpha(2)-adrenergic receptor is associated with modulation of pain, possibly through its autoregulatory effect on norepinephrine (NE) release in the CNS. The present study employs a chronic constriction nerve injury (CCI) pain model to demonstrate the interactive role of presynaptic sensitivity to TNFalpha and the alpha(2)-adrenergic autoreceptor in the pathogenesis of neuropathic pain. Accumulation of TNFalpha is increased initially in a region of the brain containing the locus coeruleus (LC) at day 4 post-ligature placement, followed by an increase in TNFalpha in the hippocampus at day 8 post-ligature placement, coincident with hyperalgesia. Levels of TNFalpha in the thoraco-lumbar spinal cord are also increased at day 8 post-ligature placement. Concurrently, alpha(2)-adrenergic receptor and TNFalpha-induced inhibition of NE release are increased, and stimulated NE release is decreased in superfused hippocampal slices isolated at day 8 post-ligature placement. Stimulated NE release is also decreased in spinal cord slices (lumbar region) from animals undergoing CCI, although in contrast to that which occurs in the hippocampus, alpha(2)-adrenergic receptor inhibition of NE release is not changed. These results indicate an important role that TNFalpha plays in adrenergic neuroplastic changes in a region of the brain that, among its many functions, appears to be a crucial link in the conscious perception of pain. We predict that neuroplastic changes, involving increased functional responses of alpha(2)-adrenergic autoreceptors and increased presynaptic sensitivity to TNFalpha, culminate in decreased NE release in the CNS. These neuroplastic changes provide a mechanism for the role of CNS-derived TNFalpha in the pathogenesis of persistent pain.
journal_name
Brain Resjournal_title
Brain researchauthors
Covey WC,Ignatowski TA,Knight PR,Spengler RNdoi
10.1016/s0006-8993(00)01965-xsubject
Has Abstractpub_date
2000-03-17 00:00:00pages
113-22issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(00)01965-Xjournal_volume
859pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:We investigated whether the weak febrile response to pyrogens in newborns is due to a diminished activation of the putative pyrogen mediator, prostaglandin (PG)E2. Indwelling cannulas in the third ventricle of lambs (age, 5-31 days) and adult ewes were used to collect cerebrospinal fluid (CSF) for radioimmunoassay of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00946-n
更新日期：1995-11-27 00:00:00
abstract：:The neuropathological consequences of acute exposure to the neurotoxicants ammonia and octanoic acid were investigated with the isolated, perfused canine brain preparation. After 1 h of combined hyperammonemia and octanoic acidemia, ultrastructural changes were apparent in all brain regions examined. The cell bodies o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90916-3
更新日期：1985-08-12 00:00:00
abstract：:Different doses of angiotensin II (AII) or angiotensin III (AIII) microinjections into the zona incerta have been studied on drinking of rats in separate experiments during the consequent 60-min-daily-drinking period. Also, the dipsogen power of only the effective dose of AII and AIII was compared to vehicle treated r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02680-5
更新日期：2003-07-11 00:00:00
abstract：:Proactive motor response inhibition is used to strategically restrain actions in preparation for stopping. In this study, we first examined the event related potential (ERP) elicited by low and high level of proactive response inhibition, as assessed by the stop-signal task. Corroborating previous studies, we found an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147064
更新日期：2020-11-15 00:00:00
abstract：:Two myelin sheaths sharing a common outer tongue process are illustrated in a thin section electron micrograph from mouse optic nerve. Although they derive from the same outer tongue process, and therefore from the same oligodendrocyte, the two sheaths are of different thicknesses (6 and 9 turns). The example demonstr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90712-6
更新日期：1983-09-12 00:00:00
abstract：:Concentrations of monoamines and metabolites and uric acid were measured in sequential 15-min microdialysis samples taken from the area of the supraoptic nucleus (SON) in 9 urethane-anaesthetized rats. A decrease in blood pressure of 40 mm Hg was induced by withdrawing 3-4 ml of blood from an indwelling jugular cathet...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91016-5
更新日期：1988-02-09 00:00:00
abstract：:It is well known that the nerve growth factor (NGF) may serve as a link between inflammation and hyperalgesia. Recent experiments showed that systemic injection of NGF dramatically stimulated the expression of brain-derived neurotrophic factor (BDNF) mRNA in the dorsal root ganglion (DRG). In the present study, we eva...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/S0006-8993(97)00048-6
更新日期：1997-02-28 00:00:00
abstract：:Previous reports of the distribution of calbindin, a 28 kDa vitamin D-induced calcium-binding protein, in the mammalian peripheral vestibular system postulated that this protein was involved in the calcium-dependent mechanisms occurring in the hair cells and ganglion cells. In this study, we examined the possibility o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90135-6
更新日期：1988-05-16 00:00:00
abstract：:The dorsal column and its nuclei exhibit a considerable number of fibers containing neuropeptides, such as calcitonin gene-related peptide (CGRP) and substance P (SP), whose origins and functional roles are as yet unknown. The present study attempts to determine the origin and nature of these fibers by means of immuno...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91225-0
更新日期：1989-08-21 00:00:00
abstract：:Parkinson's disease (PD) is characterized by progressive degeneration of nigrostriatal dopaminergic neurons. Several factors such as inhibition of the mitochondrial respiration, generation of hydroxyl radicals and reduced free radical defense mechanisms causing oxidative stress, have been postulated to contribute to t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02994-2
更新日期：2001-02-23 00:00:00
abstract：:We compared the clinical and pharmacodynamic effects of N-terminal methionine brain-derived neurotrophic factor (met-BDNF) and endogenous met-free BDNF in wobbler mouse motor neuron disease (MND). Met- or met-free BDNF at 5 or 20 mg/kg was subcutaneously injected daily, six times/week for 4 weeks. At 20 mg/kg, grip st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02881-0
更新日期：2002-07-19 00:00:00
abstract：:In this study we investigated the functional connectivity in 23 Mild TBI (mTBI) patients with and without memory complaints using resting state fMRI in the sub-acute stage of injury as well as a group of control participants. Results indicate that mTBI patients with memory complaints performed significantly worse than...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.08.034
更新日期：2013-11-06 00:00:00
abstract：:Pretreatment with recombinant human interleukin-1 alpha (rhIL-1 alpha) 20 h before irradiation attenuates radiation-induced hyperthermia. Experiments were conducted to determine the role of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) in rhIL-1 alpha-induced attenuation of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91576-e
更新日期：1993-03-19 00:00:00
abstract：:The ontogenic development of neurophysin has not been investigated so far. To study this problem, electron microscopic immunohistochemistry was performed on ultrathin sections of the posterior pituitary of foetal and newborn rats. A concomitant appearance of secretory granules and neurophysin was first noted in the po...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90007-5
更新日期：1977-07-01 00:00:00
abstract：:Levodopa (L-DOPA) is widely used for symptomatic management in Parkinson's disease. We recently showed that (-)-epigallocatechin-3-gallate, a tea polyphenol, not only inhibits L-DOPA methylation, but also protects against oxidative hippocampal neurodegeneration. In the present study, we sought to determine several oth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.043
更新日期：2013-02-25 00:00:00
abstract：:Bilateral intraventricular injections of 6-hydroxydopamine depleted dopamine (DA) in striatal tissue of rats by 88%. Tail shock increased DA in striatal extracellular fluid of these rats from 10 to 17 pg/20 microliters as measured by microdialysis, values less than half those seen in normal striatum. The increase was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91158-d
更新日期：1990-09-17 00:00:00
abstract：:This report deals with a comparison of total and regional cerebral blood flow with red cell velocity in the microcirculation of the ecto- and suprasylvian areas of the cerebral cortex of the cat and their response to changes in systemic blood pressure. Total and regional blood flows were measured during a steady-state...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90912-0
更新日期：1984-08-06 00:00:00
abstract：:The present study was undertaken to explore the neuronal mechanisms of hypocretin actions on neurons in the nucleus pontis oralis (NPO), a nucleus which plays a key role in the generation of active (REM) sleep. Specifically, we sought to determine whether excitatory postsynaptic potentials (EPSPs) evoked by stimulatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02566-6
更新日期：2003-06-27 00:00:00
abstract：:After an intraventricular administration of colchicine, the arcuate nucleus of rat hypothalamus was examined light and electron microscopically by pre-embedding immunohistochemistry for somatostatin. The arcuate nucleus exhibited numerous immunoreactive cell bodies and dense networks of immunoreactive fibers. The fibe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90312-8
更新日期：1983-03-21 00:00:00
abstract：:Metabotropic glutamate receptors (mGluRs) are thought to mediate diverse processes in brain including synaptic plasticity and excitotoxicity. These receptors are often divided into three groups by their pharmacological profiles. [3H]Glutamate binding in the presence of compounds selective for ionotropic glutamate rece...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00818-4
更新日期：1997-10-31 00:00:00
abstract：:Morphologic and metabolic aspects of androgen effects on the developing spinal cord were studied in organotypic cultures of the E13 (embryonic day 13) fetal mouse lumbosacral spinal cord, maintained as either hemisected, homologous explant pairs co-cultured with bulbocavernosus muscle (morphologic studies), or as whol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90769-4
更新日期：1987-03-17 00:00:00
abstract：:In the course of studies on the responsiveness of mediobasal hypothalamic neurons to the iontophoretic application of cortisol, it was found that positive currents applied to a sodium chloride (1 M) barrel alone, but not to a choline chloride (1 M) barrel, frequently increased the firing of these neurons. Subsequently...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91091-0
更新日期：1983-08-22 00:00:00
abstract：:In the zebrafish olfactory epithelium, three morphologically distinct olfactory neurons express different marker proteins. We utilize this feature to access developmental dynamics of one of the neuron types, the crypt cells, to determine whether they are differentiated at a stage similar to other olfactory neurons. Im...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.087
更新日期：2011-04-06 00:00:00
abstract：:In freely-moving female rats the effects of intraventricular infusion of norepinephrine (NE) on multiunit activity (MUA) were examined in the Diagonal Band of Broca (DBB), medial preoptic area (MPOA) and anterior hypothalamic area (AHA), regions containing neurons producing luteinizing hormone-releasing hormone (LHRH)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91089-1
更新日期：1981-12-07 00:00:00
abstract：:Autoradiographic techniques were used to test if positive modulators of AMPA-type glutamate receptors have regionally differentiated effects on ligand binding. Cyclothiazide, a drug with ten fold greater effects on 'flip' than 'flop' splice variants of the receptors, had unequal effects across the subdivisions of hipp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01315-2
更新日期：1998-02-02 00:00:00
abstract：:Neuronal activity in the nucleus parabrachialis medialis (NPBM) was examined in unanesthetized, unrestrained cats during each sleep-waking state. Discharge related to the cardiac cycle was assessed by calculating cross-correlation functions between neuronal and cardiac events (using the peak of the EKG 'R' wave as a r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90696-4
更新日期：1980-10-20 00:00:00
abstract：:A total of 183 nucleus basalis of Meynert (NBM) neurons were recorded in a monkey performing a delayed response task. Significant changes in discharge rate were detected in 74% of the NBM cells sampled with most responses occurring in the choice (64%) or the reward (67%) epochs of the task. Neuronal responses in the c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91529-5
更新日期：1986-12-10 00:00:00
abstract：:ACTH4-10, a fragment of the adrenocorticotropic hormone (ACTH) molecule, has marked effects on the compensation process following unilateral labyrinthectomy. In Rana temporaria ACTH4-10-treatment (5-250 micrograms/kg) influences both the acquisition and the maintenance of the compensated state. The compensation proces...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91158-1
更新日期：1982-09-23 00:00:00
abstract：:Hypoxia markedly depresses synaptic transmission in hippocampal slices of the rat. This depression is attributed to presynaptic inhibition of glutamate release and is largely mediated by adenosine released during hypoxia acting through presynaptic adenosine A(1) receptors. Paired pulse facilitation studies allowed us ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02381-7
更新日期：2000-06-30 00:00:00
abstract：:In the adult brain, γ-amino butyric acid (GABA) is an inhibitory neurotransmitter, whereas it acts as an excitatory transmitter in the immature brain, and may be involved in morphogenesis. In the present study, we immunohistochemically examined the developmental changes in GABA signaling in the embryonic mouse cervica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.003
更新日期：2012-11-27 00:00:00
