Abstract：
:The distributions of neurotensin and opiate receptors within the dorsal horn of the rat spinal cord were studied with quantitative autoradiographic techniques and compared with the immunohistochemical localizations of neurotensin and methionine-enkephalin-like immunoreactivity in this region. High densities of both neurotensin and opiate receptors were found within the superficial layers of the spinal cord, paralleling the distribution of neurotensin and enkephalin-containing interneurons and nerve terminals. Dorsal root section produced a 40% loss of opiate receptors throughout layers I and II of the spinal cord whilst no change in neurotensin receptor density or distribution was found. At the electron microscopic level the presence of neurotensin-like immunoreactivity within vesicle-containing profiles in the dorsal horn was demonstrated; however, no interaction of these terminals with primary afferent boutons was seen.
journal_name
Brain Resjournal_title
Brain researchauthors
Ninkovic M,Hunt SP,Kelly JSdoi
10.1016/0006-8993(81)90395-4subject
Has Abstractpub_date
1981-12-28 00:00:00pages
111-9issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(81)90395-4journal_volume
230pub_type
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