Abstract:
:The effects of GM1 ganglioside (30 mg/kg i.p.) administration for 22 days on choline acetyltransferase (ChAT) activity and noradrenaline (NA) levels in the cerebral cortex and on the acquisition of active and passive avoidance-conditioned responses were investigated in both sham-operated rats and in rats with a unilateral electrolytic lesion of the magnocellular forebrain nuclei (MFN). A statistically significant ChAT decrease in cortical areas ipsilateral to the lesion was found in saline-treated lesioned rats. In the lesioned GM1-treated rats, ChAT activity was only reduced in the frontoparietal areas and was significantly increased in the ipsilateral parietooccipital areas as well as in both contralateral regions. NA levels in the cortex were neither significantly affected by the lesion nor by GM1 treatment. The lesion impaired the acquisition of active and passive conditioned avoidance responses. GM1 treatment improved acquisition of the active avoidance response in the lesioned rats as indicated by a larger number of avoidances and a smaller number of escape failures during training in comparison with saline treatment. Ganglioside had no effect on the passive avoidance responses. These results demonstrate that GM1 administration facilitates the recovery of the cortical cholinergic system and of behavioral responses impaired by an electrolytic lesion of the cholinergic forebrain nuclei.
journal_name
Brain Resjournal_title
Brain researchauthors
Casamenti F,Bracco L,Bartolini L,Pepeu Gdoi
10.1016/0006-8993(85)90246-xsubject
Has Abstractpub_date
1985-07-08 00:00:00pages
45-52issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(85)90246-Xjournal_volume
338pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Although platelet-derived growth factor (PDGF)-BB activates PDGF receptor-beta (PDGFR-beta) and, in turn, inhibits the glutamate N-methyl-D-aspartate (NMDA) receptor function, whether PDGF-BB modulates the CNS function mediated by another glutamate receptors, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (A...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.05.037
更新日期:2007-07-23 00:00:00
abstract::Glial cell line-derived neurotrophic factor (GDNF) activates protein kinase Akt/PKB by phosphorylation (p-Akt) which plays key roles in cell survival. In the current study, we investigated a temporal expression of p-Akt by immunohistochemical analysis after a topical application of GDNF to normal cerebral hemisphere o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03521-7
更新日期:2002-12-27 00:00:00
abstract::The immunohistochemical distribution of substance P (SP) in the hypothalamic suprachiasmatic nucleus (SCN) was studied in adult male and female Djungarian hamsters (Phodopus sungorus) held under either long or short photoperiods. Intact animals were killed by perfusion with a fixative at the middle of the light or dar...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90649-1
更新日期:1994-02-28 00:00:00
abstract::Treatment of rat brain sections and of thalamic and striatal membranes with phosphatidylinositol phospholipase C (PIPLC), an enzyme known to hydrolyse only phosphatidylinositol and its derivatives, significantly alters the specific binding of mu- and delta-opioid ligands on their receptors. These results suggest that ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90391-n
更新日期:1990-12-24 00:00:00
abstract::A selective 5-HT reuptake inhibitor, fluvoxamine (10 and 30 mg/kg, i.p.) suppressed long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP was completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03756-3
更新日期:2003-01-03 00:00:00
abstract::In the course of pulse-label studies on the axonal transport of the small, basic, actin-binding proteins--actin depolymerizing factor, cofilin and profilin--in chicken motor neurones, we observed a heavily labelled protein of M(r) 18 kDa and pI 8.2 on fluorographs of two-dimensional polyacrylamide gels. On the basis o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00766-x
更新日期:1997-10-17 00:00:00
abstract::Butyrate treatment results in the rapid formation of processes on F98 anaplastic glioma cells. The morphological differentiation occurs more rapidly and to a greater extent than that induced by nerve growth factor (NGF). The incorporation of [3H]thymidine is virtually stopped 1 day after treatment of F98 cells with so...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90109-2
更新日期:1982-09-01 00:00:00
abstract::N-desmethylclozapine (NDMC), a major circulating metabolite of the atypical antipsychotic drug, clozapine, and has M(1) muscarinic receptor partial agonistic property. The purpose of the present study was to examine whether in vivo behavioral effects of NDMC were elicited through the activation of muscarinic receptors...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.08.056
更新日期:2011-10-18 00:00:00
abstract::In the present study we examined the laminar distributions of four types of chemically defined subpopulations of non-principal neurons, that is, those immunoreactive for parvalbumin (PV), calretinin (CR), nitric oxide synthase (NOS) and somatostatin (SS), in the rat hippocampus, by estimating their approximate numeric...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00457-5
更新日期:1997-08-01 00:00:00
abstract::During early postnatal development in reeler mutant mice, lectin binding delineates prospective abnormal barrels as they will appear in the adult mutant somatosensory cortex. Glial fibers also may be more condensed within fascicles in developing reeler barrels. These fibers also appear to be misaligned, coursing predo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90112-x
更新日期:1987-04-01 00:00:00
abstract::Monoamine oxidase A and B (MAO A and B; EC 1.4.3.4) are integral proteins of the outer mitochondrial membrane that degrade monoamines including the neurotransmitters norepinephrine, dopamine, and serotonin. In this study, monoclonal antibodies that recognize rat or monkey MAO A were used in immunocytochemical studies ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91664-e
更新日期:1993-05-28 00:00:00
abstract::We studied the short- and long-term epileptogenic effects of massed stimulation (MS) of the piriform cortex. Sprague-Dawley rats with electrodes implanted bilaterally in the anterior piriform cortex and the dorsal and ventral hippocampi underwent MS: electrical stimulation of the left piriform cortex every 5 min for 6...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00071-1
更新日期:1997-04-18 00:00:00
abstract::In vitro evidence indicates that norepinephrine release in the mammalian hippocampus is modulated by glutamate receptors. With the use of microdialysis, we have now evaluated the role of ionotropic glutamate receptors in the regulation of hippocampal norepinephrine output in vivo. Stimulation of N-methyl-D-aspartate (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.065
更新日期:2011-04-22 00:00:00
abstract::To test the hypothesis that neurons in the hypothalamic paraventricular nucleus (PVN) may be under both direct and indirect regulation by alpha melanocyte-stimulating hormone (alpha-MSH)-synthesizing neurons of the arcuate nucleus, we determined whether the retrogradely transported marker substance, cholera toxin beta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.023
更新日期:2005-12-07 00:00:00
abstract::Quantitative [125I]protein G-based immunohistochemistry was used to map the distribution of beta1 thyroid hormone receptor (TRbeta1) in normal and thyroidectomized adult rat brain, using a previously characterized polyclonal antibody. The distribution of TRbeta1-like immunoreactivity in normal brain was largely but no...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00450-2
更新日期:1997-06-27 00:00:00
abstract::Damage to the medial temporal lobe (MTL) and diencephalon results in impaired long-term memory, which relies on the binding of multiple, mostly contextual, features. Recent neuroimaging and patient studies have suggested that impairments may also be present in working memory after MTL or diencephalic damage. To examin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.066
更新日期:2007-10-03 00:00:00
abstract::Immunohistochemical and neuronal tracing methods were used in cats to determine which type of postganglionic sympathetic neuron is innervated by preganglionic neurons which contain corticotrophin releasing factor-like immunoreactivity (CRF-LI). Preganglionic neurons with CRF-LI have their cell bodies at two restricted...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90399-t
更新日期:1992-12-25 00:00:00
abstract::(1) Visual, auditory and olfactory input were not necessary for the performance of the lordosis reflex by female rats. Since taste is not involved in this behavior, somatosensory input must be sufficient for triggering the lordosis reflex. (2) Surgical cutaneous denervation markedly reduced the frequency and strength ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90987-2
更新日期:1976-01-09 00:00:00
abstract::The effects of the intraventricular administration of aluminum chloride (AlCl3) on high affinity choline transport (HAChT) and norepinephrine concentration were examined in the hippocampus of the rat. Controlling for osmolarity and pH, the intraventricular administration of AlCl3 resulted in a dose-related reduction i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91121-9
更新日期:1989-10-02 00:00:00
abstract::It is known that transmitter release depends upon the entry of calcium ions into the synaptic terminal. Mitochondria have been suggested to play a key role on the regulation of intracellular Ca2+ concentration, thereby influencing transmitter liberation and synaptic transmission. Here we report the stimulatory effect ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90618-6
更新日期:1980-01-13 00:00:00
abstract::The effect of bilateral lesion of the accessory olfactory bulb (AOB) on the mating-induced enhancement of sexual receptivity was investigated in ovariectomized (OVX) female rats. Lesions of the AOB significantly reduced the lordosis-to-mount (L/M) ratio in mating tests conducted 20 to 50 days after the lesion but L/M ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90902-4
更新日期:1994-04-11 00:00:00
abstract::Afferents from the nucleus reticularis thalami (RT) to the thalamic ventrobasal complex were studied in the rat by looking for degenerating terminals after selective neurotoxic lesion of RT using injections of kainic acid. Several lines of evidence are presented indicating that RT afferents terminate in the VB by F ty...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90607-8
更新日期:1983-07-04 00:00:00
abstract::We identified the burst and single-spiking cells, and the repetitive bursting cells in layers III and V of the cat sensorimotor cortex with intracellular recording and staining techniques. Both types of the bursting cells were found in 22.7% of the recorded layer V neurons and in 23.1% of the recorded neurons in layer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00505-7
更新日期:1996-07-15 00:00:00
abstract::To analyze mediatory mechanisms underlying attention-deficit hyperactivity disorder (ADHD) and their association with epilepsy, the electroencephalogram (EEG) responses to various centrally applied neurotransmitter agonists were studied in spontaneously hypertensive (SH), kainate-treated (KA), and normotensive (contro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.01.107
更新日期:2011-04-06 00:00:00
abstract::Concurrent activation of dopamine D1 and D2 receptors (D1 and D2) is required for the expression of certain dopamine (DA)-mediated responses, such as climbing and stereotyped behaviors. Such interactions between D1 and D2 (i.e. D1/D2 synergism) represent an important aspect of dopaminergic function and plasticity. The...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04277-4
更新日期:2003-03-28 00:00:00
abstract::Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved in ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and neurological deficits in a standardized model of transient focal cerebra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.01.078
更新日期:2004-05-08 00:00:00
abstract::Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (APV) blocked inductio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91337-g
更新日期:1990-08-13 00:00:00
abstract::The inhibitory effect of different concentrations of lithium (0.15-10 x 10(-3) M) on cAMP production induced by isoprenaline (1 x 10(-4) M) after the blockade of alpha(2)-adrenoceptors in the rat cerebral cortex was investigated. Low lithium concentrations (0.3-0.6 x 10(-3) M) exerted a significant inhibitory effect a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.019
更新日期:2003-12-19 00:00:00
abstract::The enzymatic and regulatory properties of Ca2+/calmodulin-dependent protein kinase in the postsynaptic density (mPSDp CaM kinase) of the rat forebrain was compared with those of soluble Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). mPSDp CaM kinase was different from soluble CaM kinase II in terms of s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91222-e
更新日期:1993-04-30 00:00:00
abstract::The patterns of preganglionic projections in the avian sympathetic system are highly specific. Preganglionic axons arising from the T1 spinal segment, for example, project predominantly in the rostral direction, whereas T4 preganglionic axons project predominantly in the caudal direction. Moreover, each ganglion recei...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90149-0
更新日期:1987-03-01 00:00:00