Abstract：
:Butyrate treatment results in the rapid formation of processes on F98 anaplastic glioma cells. The morphological differentiation occurs more rapidly and to a greater extent than that induced by nerve growth factor (NGF). The incorporation of [3H]thymidine is virtually stopped 1 day after treatment of F98 cells with sodium butyrate. Butyrate also caused a large increase in ornithine decarboxylase activity in F98 cells between 6 and 12 h after treatment. This was inhibited by both cycloheximide and actinomycin-D. NGF did not cause these effects. Butyrate also caused an increase in neuron-specific enolase (NSE) content in F98 cells. This effect appeared to be specific for butyrate. Since NSE induction is characteristic only of neurons and neuroendocrine cells, this finding indicates that butyrate is capable of inducing biochemical differentiation along neuronal lines in undifferentiated glioma cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Vinores SA,Marangos PJ,Ko Ldoi
10.1016/0165-3806(82)90109-2subject
Has Abstractpub_date
1982-09-01 00:00:00pages
23-8issue
1eissn
0006-8993issn
1872-6240journal_volume
281pub_type
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