An unusually small potassium current that is well-suited to a retinal neuron which is chronically depolarized.

abstract：:Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...

journal_title：Brain research

authors： Boucher Y,Simons CT,Faurion A,Azérad J,Carstens E

更新日期：2003-05-30 00:00:00

abstract：:A special feature of the extracellular matrix in adult brains of various species is the concentration of certain components around different sub-populations of neurones, giving rise to net-like structures termed perineuronal nets. Recently, some of these components have been identified but the function of these nets h...

journal_title：Brain research

authors： Haunso A,Celio MR,Margolis RK,Menoud PA

更新日期：1999-07-10 00:00:00

abstract：:Alterations in neurotrophic signaling pathways may contribute to the changes in the mesolimbic dopamine system induced by chronic morphine exposure. In a rat model of morphine dependence, we previously identified increased levels of phospholipase C gamma-1 (PLCgamma1) immunoreactivity specifically within the ventral t...

journal_title：Brain research

authors： Wolf DH,Nestler EJ,Russell DS

更新日期：2007-07-02 00:00:00

abstract：:Repeated electrode penetration of the dentate and interpositus nuclei in a rhesus monkey transformed an 11-13 Hz physiologic tremor into a much larger action tremor at 5-7 Hz. This tremor was associated with muscle spindle spike train modulation and reflexly evoked tremor modulation of interpositus and motor cortex ne...

journal_title：Brain research

authors： Elble RJ,Schieber MH,Thach WT Jr

更新日期：1984-12-10 00:00:00

abstract：:The present study demonstrates changes in rat brain glial metabolism during the acute phase of epilepsy. Status epilepticus (SE) was induced using the lithium-pilocarpine model. Glial metabolism was measured with (14)C-acetate. Local cerebral blood flow and glucose metabolism were also measured using (14)C-N-isopropyl...

journal_title：Brain research

authors： Hosoi R,Kitano D,Momosaki S,Kuse K,Gee A,Inoue O

更新日期：2010-01-22 00:00:00

abstract：:The effects of exogenous opiates upon diffuse noxious inhibitory controls (DNIC) was investigated in intact anaesthetized rats. 58 convergent neurones, responding to both noxious and innocuous stimuli applied to their cutaneous receptive fields, were recorded at the lumbar level. These cells received A- and C-peripher...

journal_title：Brain research

authors： Le Bars D,Chitour D,Kraus E,Clot AM,Dickenson AH,Besson JM

更新日期：1981-06-29 00:00:00

abstract：:Abnormal increase in native long-chain ceramides (lcCer) in AD implicates roles in neuronal atrophy and cognitive dysfunction especially in view of divergent roles this second messenger plays in cell function. Since clearance is mediated by glucosylceramide synthase (GCS, EC 2.4.1.80) levels of the enzyme were compare...

journal_title：Brain research

authors： Marks N,Berg MJ,Saito M,Saito M

更新日期：2008-01-29 00:00:00

abstract：:Choline uptake and ecto-cholinesterase activities have been measured in intact astroblast and neuroblast cultures. The data show that choline uptake is dependent upon the ionic composition of the culture medium and is sensitive to metabolic inhibitors. However, the high concentrations of the inhibitors necessary for t...

journal_title：Brain research

authors： Massarelli R,Stefanovic V,Mandel P

更新日期：1976-08-06 00:00:00

abstract：:Microtubule organization in type I hair cells has been investigated during the synaptogenesis of vestibular receptors in mammals. The different steps in the maturation of the synapse between the hair cell and the nerve chalice were: a slight symmetrical membrane densification; the appearance of synaptic bodies alongsi...

journal_title：Brain research

authors： Favre D,Dememes D,Sans A

更新日期：1986-02-01 00:00:00

abstract：:We studied whether K+, a potent cerebrovasodilator released by active neurons, participates in the increase in cortical cerebral blood flow (CBF) elicited by stimulation of the cerebellar fastigial nucleus (FN). Rats were anesthetized by continuous administration of halothane (1-3%), paralyzed and artificially ventila...

journal_title：Brain research

authors： Iadecola C,Kraig RP

更新日期：1991-11-01 00:00:00

abstract：:The effects of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), a synthetic precursor of norepinephrine (NE), on the long-term potentiation (LTP) in the hippocampal mossy fiber-CA3 system was examined in urethane-anesthetized rats, the objective being to determine whether or not this drug acts as NE on the LTP. L-thr...

journal_title：Brain research

authors： Sakai N,Sasa M,Ishihara K,Komure O,Tanaka C,Takaori S

更新日期：1991-12-20 00:00:00

abstract：:In our previous study, we have found that leucine-rich repeats and immunoglobulin-like domains 1(LRIG1) can improve the chemosensitivity in U251 cells whereas the role of LRIG1 in multidrug resistance (MDR) remains unknown. Here, we reported that LRIG1 can reverse MDR by inhibiting epidermal growth factor (EGF) recept...

journal_title：Brain research

authors： Liu B,Guo Z,Dong H,Daofeng T,Cai Q,Ji B,Zhang S,Wu L,Wang J,Wang L,Zhu X,Liu Y,Chen Q

更新日期：2015-06-22 00:00:00

abstract：:Using a double-labelling procedure, morphological relationships existing between dopaminergic and indoleaminergic neuronal systems in the rat brain were investigated. First, thanks to a tryptamine (T) antiserum, we visualized this indoleamine in all mesencephalic regions and showed that the T-immunoreactivity (IR) see...

journal_title：Brain research

authors： Dabadie H,Mons N,Geffard M

更新日期：1990-03-26 00:00:00

abstract：:Tetanization of commissural-CA1 input to the apical dendrites of the dorsal hippocampal CA1 area was found to produce a marked long-term potentiation of the field EPSP. Whereas by concurrent tetanization of the commissural pathway and medial septo-CA1 input, this potentiation was significantly reduced. Thus a negative...

journal_title：Brain research

authors： Xie XP

更新日期：1988-04-05 00:00:00

abstract：:The effects of the dopamine transporter (DAT) inhibitors cocaine and GBR12909 on DAT and dopamine D(2) receptors were evaluated in the brains under awake and isoflurane-anesthetized monkeys using high-resolution positron emission tomography (PET) in combination with microdialysis. The striatal DAT availability and dop...

journal_title：Brain research

authors： Tsukada H,Nishiyama S,Kakiuchi T,Ohba H,Sato K,Harada N,Nakanishi S

更新日期：1999-12-04 00:00:00

abstract：:Intracerebroventricular microinjection of thyrotropin-releasing hormone (TRH) potently blocked the development of, as well as promptly reversed, epinephrine-stimulated hyperglycemia in mice. The central antihyperglycemic effect was dose-related (0.1-10 micrograms), could be reproduced by an intravenous injection of a ...

journal_title：Brain research

authors： Amir S,Harel M,Rivkind AI

更新日期：1987-12-01 00:00:00

abstract：:Prominent cellular responses to axonal interruption include enhanced synthesis of RNA and protein in the neuronal perikaryon, and proliferation of reactive Schwann cells. Since morphine has been shown to significantly depress cellular metabolism, we examined its effect on these and other reparative responses underlyin...

journal_title：Brain research

authors： Sinatra RS,Ford DH

更新日期：1979-10-19 00:00:00

abstract：:This study tested the hypothesis that the short-latency excitation of the phrenic motor output elicited by superior laryngeal nerve (SLN) stimulation requires non-NMDA receptor-mediated neurotransmission in the region of the dorsal respiratory group (DRG) of the adult cat. Injection of the non-NMDA receptor antagonist...

journal_title：Brain research

authors： Karius DR,Speck DF

更新日期：1995-06-05 00:00:00

abstract：:Previous studies have reported that high concentrations of homocysteine and lower concentrations of vitamins B6, B12, and folate increase the risk for cognitive decline and pathology in aging populations. In this cross-sectional study, high resolution magnetic resonance imaging (MRI) scans and a 3-day food diary were ...

journal_title：Brain research

authors： Erickson KI,Suever BL,Prakash RS,Colcombe SJ,McAuley E,Kramer AF

更新日期：2008-03-14 00:00:00

abstract：:In an attempt to determine the basis for apparently conflicting reports of the effects of noradrenaline (NA) on the neurohypophyseal system and its effects on the parvocellular periventricular region of the paraventricular nucleus (PVN), recordings were made from the neurons in the supraoptic nucleus (SON) and the per...

journal_title：Brain research

authors： Inenaga K,Dyball RE,Okuya S,Yamashita H

更新日期：1986-03-26 00:00:00

abstract：:Stroke is the third leading cause of death in the US, with a prevalence of 750,000 patients per year, and a social cost estimated at $50 billion. Current therapeutics are targeted at restoring blood flow rather than on preventing the actual mechanisms associated with neuronal cell death. Here, we show that, following ...

journal_title：Brain research

authors： Yoshimoto T,Kanakaraj P,Ying Ma J,Cheng M,Kerr I,Malaiyandi L,Watson JA,Siesjö BK,Maples KR

更新日期：2002-08-30 00:00:00

abstract：:Intracisternal (i.c.) administration of the glutamate-receptor antagonist kynurenate to halothane-anesthetized rats (paralyzed, ventilated) produced an initial hypertension associated with an increase in lumbar sympathetic nerve discharge. Kynurenate (i.c.) blocked or greatly reduced all sympathetic reflexes investiga...

journal_title：Brain research

authors： Sun MK,Hackett JT,Guyenet PG

更新日期：1988-01-12 00:00:00

abstract：:α-Synuclein (α-syn) and oxidative stress play pivotal roles in the pathogenesis of Parkinson's disease (PD). However, the mechanisms underlying the interaction between α-syn and oxidative stress remain poorly understood. The present study provides evidence to suggest that the nuclear translocation of α-syn increases d...

journal_title：Brain research

authors： Zhou M,Xu S,Mi J,Uéda K,Chan P

更新日期：2013-03-15 00:00:00

abstract：:Perfusion of the forebrain with glucose at concentrations which alter neither plasma insulin nor glucose levels leads to sympathetic activation in some rats. We used the expression of Fos-like immunoreactivity (FLI) as an index of neuronal activation to examine the anatomic substrate underlying this phenomenon. Male S...

journal_title：Brain research

authors： Dunn-Meynell AA,Govek E,Levin BE

更新日期：1997-02-14 00:00:00

abstract：:Veratridine-induced depolarization caused a large increase in Ca uptake in the rat hippocampal slice (30.2 vs. 9.0 nM/mg dry weight). This uptake was reduced to 18.4 nM/mg when veratridine was combined with anoxia. When compared with veratridine exposure alone, the combination of anoxia and veratridine increased intra...

journal_title：Brain research

authors： Kass IS,Abramowicz AE,Cottrell JE,Amorim P,Chambers G

更新日期：1994-01-07 00:00:00

abstract：:Efflux of choline from the rat cerebral cortex in vivo was investigated using the cup technique. After removal of the dura mater, the cup was placed on the cortex. Transmission and scanning electron microscopy revealed that the cortex was separated from the cup solution (100-300 microliter) by basal lamina, pia mater,...

journal_title：Brain research

authors： Brehm R,Corradetti R,Krahn V,Löffelholz K,Pepeu G

更新日期：1985-10-21 00:00:00

abstract：:The distribution of degeneration in the vestibular nuclei (VN) has been studied in transversely cut sections from 9 cats with stereotaxically performed lesions in the main reticular formation (RF) of the brain stem (Nauta of Fink and Heimer method). No projection was found from the mesencephalic reticular formation (R...

journal_title：Brain research

authors： Hoddevik GH,Brodal A,Walberg F

更新日期：1975-09-05 00:00:00

abstract：:Ablation of tissue regions, specific genes, or specific cell types represent important means of studying function in the nervous system. Here we summarize recent experience using a strategy for the genetically-targeted and conditionally regulated ablation of astroglial cells in different parts of the nervous system. T...

journal_title：Brain research

authors： Sofroniew MV,Bush TG,Blumauer N,Lawrence Kruger,Mucke L,Johnson MH

更新日期：1999-07-17 00:00:00

abstract：:Recent anatomic studies indicate that the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla, strongly innervates the locus coeruleus (LC) while no such input derives from the more caudally located lateral reticular nucleus (LRN). In the present study, focal electrical stimulation of the...

journal_title：Brain research

authors： Ennis M,Aston-Jones G

更新日期：1987-11-10 00:00:00

abstract：:The cellular and intracellular localization of the epsilon-subspecies of protein kinase C (PKC) in the rat brain was demonstrated by immunocytochemistry using specific antibodies against epsilon-PKC. The epsilon-PKC-specific immunoreactivity was most abundant in the hippocampal formation, olfactory tubercle and Callej...

journal_title：Brain research

authors： Saito N,Itouji A,Totani Y,Osawa I,Koide H,Fujisawa N,Ogita K,Tanaka C

更新日期：1993-04-02 00:00:00