Neuroprotective effect of dapsone in an occlusive model of focal ischemia in rats.

abstract：BACKGROUND:Perinatal brain injury in preterm infants is a major cause of neurological handicap. The role of the neurotrophin receptor p75 (p75(NTR)) in the pathogenesis and repair of neonatal excitotoxic brain injury is unknown. Depending on a complex interplay of neurotrophin signalling, p75(NTR) can, in addition to i...

journal_title：Brain research

authors： Griesmaier E,Schlager G,Wegleiter K,Hermann M,Urbanek M,Simbruner G,Keller M

更新日期：2010-10-08 00:00:00

abstract：:Large neuronal perikarya isolated in bulk fractions from adult bovine ventral spinal cord and examined by electron microscopy have discontinuities in their plasma membrane. A systematic investigation of the possible causes of the membrane defects indicates that the act of mechanical dissociation of the neurons from th...

journal_title：Brain research

authors： Hester S,Capps-Covey P,McIlwain DL

更新日期：1978-12-22 00:00:00

abstract：:In our previous study, we have found that leucine-rich repeats and immunoglobulin-like domains 1(LRIG1) can improve the chemosensitivity in U251 cells whereas the role of LRIG1 in multidrug resistance (MDR) remains unknown. Here, we reported that LRIG1 can reverse MDR by inhibiting epidermal growth factor (EGF) recept...

journal_title：Brain research

authors： Liu B,Guo Z,Dong H,Daofeng T,Cai Q,Ji B,Zhang S,Wu L,Wang J,Wang L,Zhu X,Liu Y,Chen Q

更新日期：2015-06-22 00:00:00

abstract：:Antibodies were raised in rabbits against the neuropeptide N-acetyl-L-aspartyl-L-glutamate (NAAG) coupled to bovine serum albumin via a carbodiimide linkage. One of these rabbit antisera, which preferentially recognizes coupled NAAG-like immunoreactivity (LIR), has been previously used to immunocytochemically localize...

journal_title：Brain research

authors： Guarda AS,Robinson MB,Ory-Lavollée L,Forloni GL,Blakely RD,Coyle JT

更新日期：1988-06-01 00:00:00

abstract：:Cortical projection areas and distribution and response characteristics of masseteric nerve-driven neurons (MDN) were studied by recording surface-evoked potentials and single neuronal activities elicited by stimulation of the contralateral masseteric nerve in cats. Neuronal activities of MDNs could be recorded in two...

journal_title：Brain research

authors： Iwata K,Itoga H,Ikukawa A,Hanashima N,Sumino R

更新日期：1985-09-02 00:00:00

abstract：:Rats predisposed to develop diet-induced obesity (DIO) preferentially activate their sympathetic nervous system during intracarotid glucose infusion [B.E. Levin, Intracarotid glucose-induced norepinephrine response and the development of diet-induced obesity, Int. J. Obesity 16 (1992) 451-457.] but their brains are ge...

journal_title：Brain research

authors： Levin BE,Govek EK,Dunn-Meynell AA

更新日期：1998-10-19 00:00:00

abstract：:The distribution of AMPA-type glutamate receptor (GluR) subunits was studied in the Edinger-Westphal nucleus (EW) of chicks and pigeons. GluR1, GluR2, GluR3 and GluR4 subunits appeared to be present in EW neurons of both species, but interspecific differences were observed in the abundance of the different types of su...

journal_title：Brain research

authors： Toledo CA,Britto LR,Pires RS,Veenman CL,Reiner A

更新日期：2002-08-23 00:00:00

abstract：:Dopamine (DA) and noradrenaline (NA) extracellular levels have been measured by microdialysis in the medial frontal cortex (MFC), nucleus accumbens (NAc) and caudate-putamen (CP) under baseline conditions in awake and halothane-anaesthetized rats, and after application of three types of stimuli which are likely to act...

journal_title：Brain research

authors： Cenci MA,Kalén P,Mandel RJ,Björklund A

更新日期：1992-05-29 00:00:00

abstract：:Previous studies have shown that long-term 5-hydroxytryptamine (5-HT) depletion induced by combined dorsal and median raphe injections of 5,7-dihydroxytryptamine (5,7-DHT) leads to impairments in the acquisition and performance of behaviour maintained under a differential-reinforcement-of-low-rate (DRL) schedule of re...

journal_title：Brain research

authors： Fletcher PJ

更新日期：1995-03-27 00:00:00

abstract：:The effects of adaptation/stimulus temperature (25 degrees C vs. 35 degrees C) on taste nerve responses to salt stimulation and amiloride suppression were assessed in rats. We measured the integrated responses of the chorda tympani nerve to 500 mM concentrations of NaCl, Na2SO4, sodium acetate (NaAc), KCl, K2SO4, pota...

journal_title：Brain research

authors： Lundy RF Jr,Contreras RJ

更新日期：1997-01-09 00:00:00

abstract：:Opiates and cannabinoids are among the most widely consumed habit-forming drugs in humans. Several studies have demonstrated the existence of interactions between both kind of drugs in a variety of effects and experimental models. The present study has been focused to determine whether perinatal delta9-tetrahydrocanna...

journal_title：Brain research

authors： Vela G,Martín S,García-Gil L,Crespo JA,Ruiz-Gayo M,Fernández-Ruiz JJ,García-Lecumberri C,Pélaprat D,Fuentes JA,Ramos JA,Ambrosio E

更新日期：1998-10-05 00:00:00

abstract：:Previous studies have indicated that amyloid precursor protein (APP) might be a trophic agent in the nervous system, possibly through the regulation of cell adhesion and the protease/protease inhibitor activity. Additionally, APP is upregulated during the development of the nervous system. In order to further study th...

journal_title：Brain research

authors： Masliah E,Mallory M,Ge N,Saitoh T

更新日期：1992-10-16 00:00:00

abstract：:In a previous study, we demonstrated that cholera toxin-A subunit, as well as the whole toxin, selectively blocks opioid-induced prolongation of the Ca2+ component of the action potential duration (APD) in dorsal root ganglion (DRG) neurons, indicating mediation of this excitatory effect by Gs-linked opioid receptors....

journal_title：Brain research

authors： Shen KF,Crain SM

更新日期：1990-10-29 00:00:00

abstract：:The ability of embryonic tissue to survive cross-transplantation between histologically incompatible rat strains was examined by transplanting septal neurons from Sprague Dawley fetuses to adult Wistar rats (Ag-B6 to Ag-B2 histocompatibility haplotype). Transplants were found to survive without rejection over a period...

journal_title：Brain research

authors： Low WC,Lewis PR,Terri ST

更新日期：1983-03-07 00:00:00

abstract：:Previous research has shown that, in freely moving laboratory rats, the odors of benzyl alcohol, camphor, carvacrol, isopentenyl methyl sulfide, 2-propylthietane, salicylaldehyde, trimethylthiazoline, and xylene (plus other compounds) elicit high amplitude bursts of roughly 20-Hz waves (beta-waves) in the olfactory bu...

journal_title：Brain research

authors： Vanderwolf CH,Zibrowski EM,Wakarchuk D

更新日期：2002-01-11 00:00:00

abstract：:The effects of sodium valproate on extracellularly recorded spontaneous neuronal activity and its interaction with GABA-induced inhibition were assessed in the rat medial basal hypothalamus both in situ and in explant culture. In situ, valproate enhanced the spontaneous rate in 14 of 20 neurons sampled, 6 neurons were...

journal_title：Brain research

authors： Baldino F Jr,Geller HM

更新日期：1981-08-24 00:00:00

abstract：:Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 ...

journal_title：Brain research

authors： Reinhard M,Lorenz L,Sommerlade L,Allignol A,Urbach H,Weiller C,Egger K

更新日期：2019-08-15 00:00:00

abstract：:Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3',5'-cyclic monophosphate (i-cGMP) was increased, while immunoreactive adenosine 3',5'-cyclic monophosphate (i-cAMP) was decrea...

journal_title：Brain research

authors： Garry MG,Richardson JD,Hargreaves KM

更新日期：1994-05-16 00:00:00

abstract：:Bradykinin is known to rapidly elevate intracellular calcium leading to secretion of neurotransmitters and short term activation of tyrosine hydroxylase (TH). In this study we examined the effect of bradykinin on mRNA levels of two catecholamine biosynthetic enzymes. Treatment of PC12 cells with 1 microM bradykinin fo...

journal_title：Brain research

authors： Gebreyesus K,Kilbourne EJ,Sabban EL

更新日期：1993-04-16 00:00:00

abstract：:In this study we used two lines of transgenic mice overexpressing tumor necrosis factor alpha (TNF-alpha) in the central nervous system (CNS), one characterized by reactive gliosis, inflammatory demyelination and neurological deficits (Tg6074) the other showing no neurological or phenotypical alterations (TgK3) to inv...

journal_title：Brain research

authors： Aloe L,Properzi F,Probert L,Akassoglou K,Kassiotis G,Micera A,Fiore M

更新日期：1999-09-04 00:00:00

abstract：:In the hippocampus, BK channels are preferentially localized in presynaptic glutamatergic terminals including mossy fibers where they are thought to play an important role regulating excessive glutamate release during hyperactive states. Large conductance calcium-activated potassium channels (BK, MaxiK, Slo) have rece...

journal_title：Brain research

authors： Pacheco Otalora LF,Hernandez EF,Arshadmansab MF,Francisco S,Willis M,Ermolinsky B,Zarei M,Knaus HG,Garrido-Sanabria ER

更新日期：2008-03-20 00:00:00

abstract：:The olivary pretectal nucleus is a primary visual centre sensitive to luminance changes. It is involved in the pupillary light reflex, the consensual pupillary light reflex and related reflexes, such as the lid closure reflex whereby pupillary constriction takes place. Since the olivary pretectal nucleus is a small nu...

journal_title：Brain research

authors： Klooster J,Vrensen GF,Müller LJ,van der Want JJ

更新日期：1995-08-07 00:00:00

abstract：:The cholinergic agonist pilocarpine injected intraperitoneally (ip) increases mean arterial pressure (MAP) and superior mesenteric (SM) vascular resistance and reduces submandibular/sublingual gland (SSG) vascular resistance. In the present study, we investigated the effects of electrolytic lesions of the anteroventra...

journal_title：Brain research

authors： Takakura AC,Moreira TS,De Luca LA Jr,Renzi A,Menani JV,Colombari E

更新日期：2005-09-07 00:00:00

abstract：:The localization of a GTP-binding protein (G(o)) in the cerebellar and cerebral cortex and hippocampus of the normal and reeler mutant mouse was immunohistochemically examined using affinity-purified antibody raised against the alpha subunit of G(o). Although the general distribution pattern of G(o)-immunoreactive pro...

journal_title：Brain research

authors： Terashima T,Katada T,Ichikawa R,Ui M,Inoue Y

更新日期：1993-01-22 00:00:00

abstract：:The analgesia induced by 30-s footshock (1 mA) is enhanced and attenuated by decreasing and increasing the extraneuronal availability of serotonin (5-HT), respectively. In the present work we have shown the effect to be mediated by spinal 5-HT systems as the response was increased by depletion of spinal but not brain ...

journal_title：Brain research

authors： Hutson PH,Tricklebank MD,Curzon G

更新日期：1982-04-15 00:00:00

abstract：:The central nervous system of the mollusc Helix pomatia was stimulated with NO donors sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) or hydroxylamine, in the presence of a phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine (IBMX). Radioimmunoassay revealed that all of the three NO donors signi...

journal_title：Brain research

authors： Huang S,Kerschbaum HH,Hermann A

更新日期：1998-01-12 00:00:00

abstract：:The chronic dietary intake of essential polyunsaturated fatty acids (PUFAs) can modulate learning and memory by being incorporated into neuronal plasma membranes. Representatives of two PUFA families, the n-3 and n-6 types become integrated into membrane phospholipids, where the actual (n-6)/(n-3) ratio can determine ...

journal_title：Brain research

authors： Farkas E,de Wilde MC,Kiliaan AJ,Meijer J,Keijser JN,Luiten PG

更新日期：2002-11-01 00:00:00

abstract：:Cholecystokinin-octapeptide-like-immunoreactivity (CCK-8-LI) is demonstrable by the indirect immunofluorescent technique in cerebral cortical neurons cultured from fetal rats. Prominent and widespread staining is seen in widely ramifying cellular processes throughout the cultures. Staining in neuronal cell bodies is e...

journal_title：Brain research

authors： Delfs JR,Zhu CH,Dichter MA

更新日期：1984-02-13 00:00:00

abstract：:Cholecystokinins in rat cerebral cortex were studied by radioimmunoassay using an antiserum specific for the COOH-terminus of CCK8. Total concentrations of immunoreactive CCK in cortex were 3-4 fold higher than in jejunum. Rat cerebral CCK was purified by immuno-affinity adsorption to the IgG fraction of CCK antisera ...

journal_title：Brain research

authors： Dockray GJ

更新日期：1980-04-21 00:00:00

abstract：:The hypothesis that early social isolation results in long-term alterations in dopamine receptor sensitivity was tested using older adult rhesus monkeys. Isolated and control monkeys were challenged with apomorphine (0.1 and 0.3 mg/kg), and the drug effects on spontaneous blink rate, stereotyped behavior, and self-inj...

journal_title：Brain research

authors： Lewis MH,Gluck JP,Beauchamp AJ,Keresztury MF,Mailman RB

更新日期：1990-04-09 00:00:00