Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy.

abstract：:Anterograde and retrograde axonal tracing methods have been combined with transection of the stria terminalis to investigate the centrifugal afferent connections of the accessory olfactory bulb in the mouse. Injection of tritiated proline into the postero-medial cortical amygdaloid nucleus (C3) gives rise to anterogra...

journal_title：Brain research

authors： Barber PC

更新日期：1982-08-12 00:00:00

abstract：:Cerebral autoregulation was tested here in 3- and 18-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) was measured in each rat using radioactive micropheres under unanesthetized control conditions and after hypotension induced by ganglionic blockade. Under cont...

journal_title：Brain research

authors： Hoffman WE,Albrecht RF,Miletich DJ

更新日期：1981-06-09 00:00:00

abstract：:The patch-clamp technique was used to characterize the single channel ion currents in primary cultures of rat astrocytes. The most dominant channel type, which was found in over half of the inside-out membrane patches, was a potassium channel. The measured reversal potential was -67 mV, which is close to the calculate...

journal_title：Brain research

authors： Jalonen T,Holopainen I

更新日期：1989-04-10 00:00:00

abstract：:The aim of the present study was to develop a model culture system for the study of factors controlling regeneration of axons from injured adult mammalian central nervous system. We show, for the first that retinal ganglion cells (RGC) dissociated from adult rat retina, regrow processes in vitro over long distances un...

journal_title：Brain research

authors： Wigley CB,Berry M

更新日期：1988-07-01 00:00:00

abstract：:The aim of the present report is to investigate in detail morphometric changes of axon terminals of area 17 of adult cat induced by methylmercury intoxication. Six adult male cats (Felix catus), with 12 h day-light cycle and ad libitum water and food regimen, received a single dose of MeHgCl (6.4 mg/kg) dissolved in m...

journal_title：Brain research

authors： de Oliveira RB,Gomes Leal W,Picanço-Diniz DL,Torres Neto JB,Lins N,Malm O,Picanço-Diniz CW

更新日期：2008-12-09 00:00:00

abstract：:Fluorescence immunohistochemistry was performed to characterize the distribution and phenotype of GLUT8-positive neurons in rat brain and to compare the cellular distribution of GLUT8 with GLUT3 in the hippocampus. Based upon the absence of co-localization with the non-neuronal markers GFAP (astroglial) and OX42 (micr...

journal_title：Brain research

authors： Reagan LP,Rosell DR,Alves SE,Hoskin EK,McCall AL,Charron MJ,McEwen BS

更新日期：2002-04-05 00:00:00

abstract：:Early adverse events have been shown to increase the incidence of interstitial cystitis/painful bladder syndrome in adulthood. Despite high clinical relevance and reports of stress-related symptom exacerbation, animal models investigating the contribution of early life stress to female urological pain are lacking. We ...

journal_title：Brain research

authors： Pierce AN,Di Silvestro ER,Eller OC,Wang R,Ryals JM,Christianson JA

更新日期：2016-05-15 00:00:00

abstract：:Tourette syndrome (TS) is a childhood-onset tic disorder associated with abnormal development of brain networks involved in the sensory and motor processing. An involvement of immune mechanisms in its pathophysiology has been proposed. Animal models based on active immunization with bacterial or viral mimics, direct i...

journal_title：Brain research

authors： Martino D,Zis P,Buttiglione M

更新日期：2015-08-18 00:00:00

abstract：:The effect of (S)alpha-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region...

journal_title：Brain research

authors： Sugimoto K,Abe K,Lee TH,Sakurai E,Yanai K,Kogure K,Itoyama Y,Watanabe T

更新日期：1994-12-15 00:00:00

abstract：:Recently, missense mutations in the gene TARDBP encoding TDP-43 have been linked to familial ALS. The discovery of genes encoding these RNA binding proteins, such as TDP-43 and FUS/TLS, raised the notion that altered RNA metabolism is a major factor underlying the pathogenesis of ALS. To begin to unravel how mutations...

journal_title：Brain research

authors： Tsao W,Jeong YH,Lin S,Ling J,Price DL,Chiang PM,Wong PC

更新日期：2012-06-26 00:00:00

abstract：:Gabapentin, a drug useful in several neurological and psychiatric disorders, decreased K(+) (15 mM)-induced [Ca(2+)](i) increase in Fura-PE3-loaded rat neocortical synaptosomes (IC(50)=9.7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response ...

journal_title：Brain research

authors： Meder WP,Dooley DJ

更新日期：2000-09-01 00:00:00

abstract：:We have examined the influence of reducing conditions on the activity of group-I or -II metabotropic glutamate receptors. In cultured cerebellar granule cells or in hippocampal slices, the reducing agent dithiothreitol (DTT) inhibited the stimulation of polyphosphoinositide (PPI) hydrolysis elicited by group-I mGlu re...

journal_title：Brain research

authors： Copani A,Romano C,Di Giorgi Gerevini V,Nicosia A,Casabona G,Storto M,Mutel V,Nicoletti F

更新日期：2000-06-09 00:00:00

abstract：:Chronic developmental exposure to ethanol can lead to a wide variety of teratogenic effects, which in humans are known as fetal alcohol spectrum disorders (FASD). Individuals affected by FASD may exhibit persistent impairments to cognitive functions such as learning, memory, and attention, which are highly dependent o...

journal_title：Brain research

authors： Louth EL,Luctkar HD,Heney KA,Bailey CDC

更新日期：2018-01-01 00:00:00

abstract：:Specific binding of [3H]naloxone to rat brain tissue in vitro was inhibited by the excitant organochlorinated insecticides (OCI), by ether (E) and octanol (OCT), and by the convulsant indoklon (IND) and its anesthetic isomer, isoindoklon (ISO). In the presence of 100 mM NaCl the inhibition of naloxone binding by E, OC...

journal_title：Brain research

authors： Labella FS

更新日期：1981-08-24 00:00:00

abstract：:In this study, the effects of early vs. delayed tPA treatment on the development of hemorrhagic transformation was compared in a rat thromboembolic model of stroke. Fibrinolysis was performed by administering tPA intravenously at 2 or 6 h after ischemic onset. Twenty-four hours later, confluent hemorrhagic infarction ...

journal_title：Brain research

authors： Kano T,Katayama Y,Tejima E,Lo EH

更新日期：2000-01-31 00:00:00

abstract：:The present study examined the role of the sympathetic nervous system as a mediator of the message from the CNS to the kidneys to stimulate the secretion of renin. Two procedures that increase the secretion of renin were tested: administration of the serotonin releaser fenfluramine, which increases renin release witho...

journal_title：Brain research

authors： Morton KD,Johnson MD,Van de Kar LD

更新日期：1995-11-06 00:00:00

abstract：:Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...

journal_title：Brain research

authors： McCown TJ,Xiao X,Li J,Breese GR,Samulski RJ

更新日期：1996-03-25 00:00:00

abstract：:Neurotransmitter effects were studied on in vitro release of immunoreactive somatostatin (SRIF) from slices prepared from several regions of the rat brain: mediobasal hypothalamus (MBH), preoptic anterior hypothalamic area (POA) and amygdaloid complex (AMY). Potassium (K+, 56 mM) stimulated SRIF release in all structu...

journal_title：Brain research

authors： Epelbaum J,Tapia-Arancibia L,Kordon C

更新日期：1981-06-29 00:00:00

abstract：:Striatal glial cell line-derived neurotrophic factor (GDNF) mRNA levels in both young (2-month old) and old (11-month old) C57BL/6J mice were quantified at 3, 7 and 21 days following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. MPTP did not alter the expression of GDNF mRNA in these animals. Immunore...

journal_title：Brain research

authors： Inoue T,Tsui J,Wong N,Wong SY,Suzuki F,Kwok YN

更新日期：1999-05-01 00:00:00

abstract：:Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O(2)) or intermittent hypoxia (IH; 10% and ...

journal_title：Brain research

authors： Li RC,Lee SK,Pouranfar F,Brittian KR,Clair HB,Row BW,Wang Y,Gozal D

更新日期：2006-06-22 00:00:00

abstract：:Whereas the role of the hippocampus for spatial learning and long-term memory is largely undisputed, there is less evidence for a participation of hippocampal structures in spatial working memory operations. In an fMRI study (functional magnetic resonance imaging), we therefore examined the role of the hippocampus dur...

journal_title：Brain research

authors： Toepper M,Markowitsch HJ,Gebhardt H,Beblo T,Thomas C,Gallhofer B,Driessen M,Sammer G

更新日期：2010-10-01 00:00:00

abstract：:Quantitative in vitro autoradiography was used to examine [3H]D-Ala2, MePhe4, Gly-015 enkephalin (DAGO) (mu-agonist) and [3H]diprenorphine (general opiate antagonist) binding sites in the hippocampal formation of young (6-8 months) and aged (25-28 months) Long-Evans rats. Age-related changes in these binding sites wer...

journal_title：Brain research

authors： Nagahara AH,Gill TM,Nicolle M,Gallagher M

更新日期：1996-01-22 00:00:00

abstract：:The present study aimed to determine the kinetics of L-3, 4-dihydroxyphenylalanine (L-DOPA) uptake in an immortalised cell line of rat capillary cerebral endothelial cells (clones RBE 4 and RBE 4B), to define the type of inhibition produced by L-5-hydroxytryptophan (L-5-HTP), 2-aminobicyclo(2,2,1)-heptane-2-carboxylic...

journal_title：Brain research

authors： Gomes P,Soares-da-Silva P

更新日期：1999-05-22 00:00:00

abstract：:Two different ligands, tritiated oxytocin and a newly synthesized and monoiodinated oxytocin antagonist, were used to reveal sites which bind oxytocin in the brainstem and upper spinal cord of 12 human subjects. Tissue sections were incubated with either ligand at a concentration close to their respective dissociation...

journal_title：Brain research

authors： Loup F,Tribollet E,Dubois-Dauphin M,Pizzolato G,Dreifuss JJ

更新日期：1989-10-23 00:00:00

abstract：:Hippocampal long-term potentiation (LTP) is considered as a cellular model of memory formation. Specific, electrical weak tetanization of distinct afferents such as the medial perforant path results in a short-lasting, protein synthesis-independent early-LTP (up to 4 h) within the dentate gyrus. A stronger tetanizatio...

journal_title：Brain research

authors： Neugebauer F,Korz V,Frey JU

更新日期：2009-06-01 00:00:00

abstract：:Immunohistochemical localization of brain-derived neurotrophic factor (BDNF) in the monkey brain was investigated using a polyclonal anti-BDNF antibody produced in our laboratory. The antibody recognized a single band in monkey brain homogenates, and the estimated molecular weight was approximately 14 kDa, which corre...

journal_title：Brain research

authors： Kawamoto Y,Nakamura S,Kawamata T,Akiguchi I,Kimura J

更新日期：1999-03-13 00:00:00

abstract：:Damage to the cerebral endothelium from ischemia could exacerbate brain injury by altering vascular integrity, but little is known concerning the response of cerebral endothelial cells to hypoxia. To address this issue, cerebral capillary endothelial cells were isolated from 14-day-old rats, grown to confluence, and p...

journal_title：Brain research

authors： Gobbel GT,Chan TY,Gregory GA,Chan PH

更新日期：1994-08-08 00:00:00

abstract：:Neuronal degeneration was detected in the tenia tecta and other regions of the anterior limbic system of male weanling rats 3 days after four doses of 5 mg/kg d-amphetamine (4 x 5 mg/kg AMPH) when seizures occurred during AMPH exposure. Neurodegeneration in the parietal cortex, loss of tyrosine hydroxylase immunoreact...

journal_title：Brain research

authors： Bowyer JF

更新日期：2000-12-08 00:00:00

abstract：:The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion. In comparison with the control group, indomethacin sig...

journal_title：Brain research

authors： Phillis JW,Smith-Barbour M,Perkins LM,O'Regan MH

更新日期：1994-08-01 00:00:00

abstract：:The basic characteristics of the electroencephalograms (EEGs) of the entorhinal cortex (EC) were compared to those of the olfactory bulb (OB) and prepiriform cortex (PPC) in the awake cat, using methods that take into account linear (coherence functions) and non-linear relationships (mutual information). The frequency...

journal_title：Brain research

authors： Boeijinga PH,Lopes da Silva FH

更新日期：1988-05-17 00:00:00