Abstract：
:The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion. In comparison with the control group, indomethacin significantly attenuated the ischemia-evoked release of glutamate and aspartate, but not of GABA. Adenosine levels in the cortical superfusates were significantly elevated following indomethacin administration. As indomethacin is a potent inhibitor of adenosine uptake, these results suggest that, by blocking adenosine uptake, indomethacin could elevate extracellular adenosine levels and depress glutamate and aspartate efflux as a consequence of the activation of adenosine A1 receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Phillis JW,Smith-Barbour M,Perkins LM,O'Regan MHdoi
10.1016/0006-8993(94)90248-8subject
Has Abstractpub_date
1994-08-01 00:00:00pages
353-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)90248-8journal_volume
652pub_type
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