Abstract:
:Little is known about the association between brain white matter (WM) structure and motor function in humans. This study investigated complexity of brain WM interior shape as determined by magnetic resonance imaging (MRI) and its relationship with upper-extremity (UE) motor function in patients post stroke. We hypothesized that (1) the WM complexity would decrease following stroke, and (2) higher WM complexity in non-affected cortical areas would be related to greater UE motor function. Thirty-eight stroke patients (16 with left-hemisphere lesions) underwent MRI anatomical brain scans. Fractal dimension (FD), a quantitative shape metric, was applied onto skeletonized brain WM images to evaluate WM internal structural complexity. Wolf Motor Function Test (WMFT) and Fugl-Meyer Motor Assessment (FM) scores were measured to assess motor function of the affected limb. The WM complexity was lower in the stroke-affected hemisphere. The FD was associated with better motor function in two subgroups: with left-subcortical lesions, FD values of the lesion-free areas of the left hemisphere were associated with better FM scores; with right-cortical lesions, FD values of lesion-free regions were robustly associated with better WMFT scores. These findings suggest that greater residual WM complexity is associated with less impaired UE motor function, which is more robust in patients with right-hemisphere lesions. No correlations were found between lesion volume and WMFT or FM scores. This study addressed WM complexity in stroke patients and its relationship with UE motor function. Measurement of brain WM reorganization may be a sensitive correlate of UE function in people recovering from stroke.
journal_name
Brain Resjournal_title
Brain researchauthors
Zhang L,Butler AJ,Sun CK,Sahgal V,Wittenberg GF,Yue GHdoi
10.1016/j.brainres.2008.06.008subject
Has Abstractpub_date
2008-09-04 00:00:00pages
229-40eissn
0006-8993issn
1872-6240pii
S0006-8993(08)01366-8journal_volume
1228pub_type
杂志文章,多中心研究相关文献
BRAIN RESEARCH文献大全abstract::Several forebrain areas have been shown to project to the parabrachial nucleus (PBN) and exert inhibitory and excitatory influences on taste processing. The neurochemicals by which descending forebrain inputs modulate neural taste-evoked responses remain to be established. This study investigated the existence of soma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.038
更新日期:2009-11-17 00:00:00
abstract::Time-course expression of Bax and Bcl-2 proteins, identified as apoptosis-regulating molecules, was assessed in gerbil hippocampus following transient forebrain ischemia. Brain sections from animals sacrificed at 48, 72, 96 h and 7 days following 5 min ischemia were immunohistochemically evaluated using polyclonal ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01436-5
更新日期:1996-03-04 00:00:00
abstract::The aim of this work was to characterize the interaction of the Na+-channel toxin, purified from venom of the scorpion Leiurus quinquestriatus, with microtubule proteins in vitro. The toxin enhanced microtubule assembly, causing the formation of microtubule 'bundles'. It interacted with the Na+-channel 270 kDa subunit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(86)90019-7
更新日期:1986-07-01 00:00:00
abstract::The effects of selective dopamine (DA) depleting lesions with 6-hydroxydopamine microinjection into the SN, CPu, and NAS, as well as radiofrequency lesions of the CPu on the performance characteristics of rats trained on a single-valued 20-s peak-interval (PI) timing procedure or a double-valued 10-s and 60-s PI proce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.06.031
更新日期:2006-09-13 00:00:00
abstract::Detailed quantitative information on catecholamines and 5-hydroxytryptamine (serotonin) in the human thalamus is much needed because of increasing interest in norepinephrine and serotonin as modulators of thalamic behavioral state control and overall information processing. This study provides three-dimensional distri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00404-6
更新日期:1997-07-18 00:00:00
abstract::Endogenous gamma-aminobutyric acid (GABA) release from the rat medial preoptic area (MPOA) was measured in an in vitro slice technique with sensitive HPLC analysis. Oestrogen is demonstrated to increase GABA activity in the ovariectomised, oestrogen-primed (OVX-EB) rat prior to the luteinising hormone (LH) surge compa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91295-x
更新日期:1989-05-01 00:00:00
abstract::It has been hypothesised that the increased life span commonly observed in rodents that have had their diet restricted after weaning may be related to its effects on the anti-oxidant defence systems. However, undernutrition during the gestation and pre-weaning period is known to have long-term deleterious effects on a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.046
更新日期:2008-07-30 00:00:00
abstract::After studying pathway selection in the brain of Rana pipiens during unilateral optic nerve regeneration, several frogs were allowed to survive for lengthy periods for use in the present investigation. Retina flat-mounts were prepared from both eyes at 42-50 weeks postoperation. In some cases, HRP was infiltrated into...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90804-2
更新日期:1985-10-07 00:00:00
abstract::The mesolimbic dopamine (DA) system has long been known to be involved in reward behaviors. As with other substances of abuse, it has been extensively reported that ethanol influences the dopaminergic system. The present study examined whether selectively bred Sardinian-alcohol-preferring (sP) and Sardinian alcohol no...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03296-6
更新日期:2002-01-11 00:00:00
abstract::Application of horseradish peroxidase (HRP) to the proximal stump of the transected infraorbital (IO) nerve in the orbit was employed in normal adult rats to demonstrate the ganglionic representation of and brainstem innervation by the trigeminal (V) branch which supplies primarily the mystacial vibrissae. In the V ga...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90970-8
更新日期:1983-06-13 00:00:00
abstract::Sequential effects--reduced behavioral interference after incongruent trials-provide a unique opportunity to examine the influence of previous experience on current attentional processing. We conducted a theoretical analysis of performance in the Simon paradigm to distinguish an attention account (conflict adaptation)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.003
更新日期:2009-11-10 00:00:00
abstract::Visual spatial orienting of attention towards exogenous cues has been one of the attentional functions considered to be spared in ADHD. Here we present a design in which 60 (30 ADHD) children, age: 10.9±1.4, were asked to covertly orient their attention to one or two (out of four) cued locations, and search for a targ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.11.036
更新日期:2013-02-01 00:00:00
abstract::A large body of evidence indicates that both the altered cytokines that mediate the immune-inflammatory process and abnormal gray matter are associated with schizophrenia. Whether peripheral cytokines are related to cerebral structural abnormality remains unclear. Therefore, we aimed to investigate the association of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146463
更新日期:2019-12-01 00:00:00
abstract::Noise analysis was used to estimate the single-channel conductance and number of channels responsible for the mechanically-activated current in the sensory neurons of a spider mechanoreceptor organ. External slits of the VS-3 slit-sense organ in the patellar cuticle of Cupiennius salei were moved with a piezoelectric ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01276-7
更新日期:1999-05-01 00:00:00
abstract::The carotid body of the mouse is ideally suited for in vitro photometric and fluorometric studies using transillumination. It is small, thin and translucent. Photometric recordings were made by using a dual wavelength method. Wavelengths of 550 nm (maximal absorbance, MA) and 540 nm (isosbestic point, IP) were employe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90019-8
更新日期:1985-03-18 00:00:00
abstract::The effects of oligemia (moderate ischemia) on the brain need to be explored because of the potential role of subtle microvascular changes in vascular cognitive impairment and dementia. Chronic bilateral common carotid artery occlusion (BCCAO) in adult rats has been used to study effects of oligemia (hypoperfusion) us...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.06.018
更新日期:2005-08-02 00:00:00
abstract::Olfactory nerve input is required for the normal expression of tyrosine hydroxylase (TH) by dopaminergic neurons in the glomerular region of the rodent main olfactory bulb. To determine whether the olfactory nerve exerts a similar influence on neurons in other brain regions, we performed unilateral bulbectomies in rat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90977-3
更新日期:1989-09-11 00:00:00
abstract::ENT1 is an equilibrative nucleoside transporter that enables trans-membrane bi-directional diffusion of biologically active purines such as adenosine. In spinal cord dorsal horn and in sensory afferent neurons, adenosine acts as a neuromodulator with complex pro- and anti-nociceptive actions. Although uptake and relea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.08.017
更新日期:2005-10-19 00:00:00
abstract::The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (2...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01952-6
更新日期:1999-10-16 00:00:00
abstract::During the re-entrainment of the rat pineal N-acetyltransferase (NAT) rhythm to an 8-h advance of a light-dark (LD) cycle accomplished by shortening of one dark period, the advanced light period phase-delayed the evening NAT rise and phase-advanced the morning decline. The phase-relationship between the rise and the d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90605-7
更新日期:1989-08-14 00:00:00
abstract::Glutamate kills sensitive neurons through several steps downstream to receptor activation: increased free Ca2+ levels, activation of various enzymes and accumulation of reactive oxygen species (ROS). We have evaluated in a well established model of neuronal cultures the neuroprotective effects of blocking these mechan...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-07-22 00:00:00
abstract::The relationship between carotid body chemoreceptor activity and flow was studied in preparations superfused in vitro. The carotid bodies were excised from pentobarbitone-anesthetized cats and superfused with modified Tyrode's solution, buffered with HEPES-NaOH to pH 7.41. The bath temperature was kept constant at 37....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90110-2
更新日期:1988-07-05 00:00:00
abstract::Using immunohistochemistry and immunoblots, we show that alterations in hippocampal microtubule-associated protein-2 appear to be highly correlated with contextual memory as measured by significantly heightened fear responses. Compared to naive controls, rats trained in a novel context showed significantly increased i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01064-1
更新日期:1999-03-06 00:00:00
abstract::The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically signif...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90311-5
更新日期:1981-08-31 00:00:00
abstract::The distribution of S-100-immunoreactive material was examined in the central nervous system of the gastropod snail. Helix pomatia, and electrophysiological properties of S-100-positive neurons were characterized. Immunocytochemical studies revealed S-100-like protein to be present in neurons localized in the cerebral...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01584-1
更新日期:1996-04-15 00:00:00
abstract::Previous data suggest a relationship between the loss of response to levodopa in Parkinson's disease (PD) patients with the co-occurrence of dementia, but the role of alterations in the dopamine system has not been explored. We measured the extent of striatal DA loss and changes in striatal DA D(2) and D(3) receptors ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03396-6
更新日期:2002-11-15 00:00:00
abstract::The present study examined the antioxidant effect of phytic acid on iron (II)-enhanced hydroxyl radical (*OH) generation induced by 1-methyl-4-phenylpyridinium ion (MPP(+)) in the extracellular fluid of rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02830-0
更新日期:2003-07-18 00:00:00
abstract::Enriched environment (EE) has been shown to have beneficial effects on cognitive recovery after brain injury. Typical EE comprises three components: (i) enlarged living area providing physical activation, (ii) sensory stimulation, and (iii) social stimulation. The present study assessed the specific contribution of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.10.019
更新日期:2015-12-10 00:00:00
abstract::The lactating rat has been shown to lack a behavioral response and immediate early gene expression (cFos) in the hippocampus (Hipc) following intravenous or intracerebroventricular administration of an N-methyl-d-aspartate (NMDA) receptor agonist. The purpose of this study is to determine whether neurons in the Hipc h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01069-5
更新日期:1998-12-14 00:00:00
abstract::The ability of the rat sciatic nerve to regenerate into a previously frozen distal nerve segment was studied and compared to regeneration after a crush lesion. The regeneration rate in the frozen segment was 1.9 mm/day, which was approximately half of that observed after a crush lesion (3.3 mm/day). If an unfrozen ner...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90161-8
更新日期:1988-06-21 00:00:00