Abstract：
:The present study examined the antioxidant effect of phytic acid on iron (II)-enhanced hydroxyl radical (*OH) generation induced by 1-methyl-4-phenylpyridinium ion (MPP(+)) in the extracellular fluid of rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused through a microdialysis probe to detect the generation of *OH as reflected by the non-enzymatic formation of 2,3-dihydroxybenzoic acid (DHBA) in the striatum. Phytic acid (100 microM) did not significantly decrease the levels of MPP(+)-induced *OH formation trapped as 2,3-DHBA. To confirm the generation of *OH by the Fenton-type reaction, iron (II) was infused through a microdialysis probe. Introduction of iron (II) (10 microM) enhanced MPP(+) induced *OH generation. However, phytic acid significantly suppressed iron (II)-enhanced *OH formation after MPP(+) treatment (n=6, P<0.05). These results suggest that the antiradical effect of phytic acid occurs by chelating iron required for the MPP(+)-enhanced *OH generation via the Fenton-type reaction.
journal_name
Brain Resjournal_title
Brain researchauthors
Obata Tdoi
10.1016/s0006-8993(03)02830-0subject
Has Abstractpub_date
2003-07-18 00:00:00pages
241-4issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899303028300journal_volume
978pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Intraocular injections of several different retrograde tracers were made in albino rats. Retrogradely filled neurons were observed in two locations: the medial pretectal area and the contralateral periaqueductal grey matter, indicating that the pretectum and the mesencephalon are sources of centrifugal innervation to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90046-0
更新日期：1985-02-11 00:00:00
abstract：:Two pathways that have been shown to mediate cerebral ischemic damage are the MEK/ERK cascade and the pro-apoptotic deltaPKC pathway. We investigated the relationship between these pathways in a rat model of focal ischemia by observing and modifying the activation state of each pathway. The ERK1/2 inhibitor, U0126, in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.051
更新日期：2009-01-28 00:00:00
abstract：:An extensive exploration of the discriminating properties of olfactory receptors cells has been conducted in our laboratory through the statistical processing of single cell responses recorded in the frog's olfactory epithelium. Similarities between odorant stimulating properties could be demonstrated by comparing the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90764-9
更新日期：1984-02-06 00:00:00
abstract：:Whole-cell patch-clamp recordings were used to investigate electrophysiological effects of neurotensin on acutely isolated dopaminergic (DA) neurons of the rat substantia nigra pars compacta (SNC). During current-clamp recordings, neurotensin depolarized DA neurons and triggered action potentials. Under voltage-clamp ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00379-5
更新日期：1995-06-19 00:00:00
abstract：:Distribution of somatostatin (SS) immunoreactivity was observed in the preoptic-anterior hypothalamus (PO-AH) of the female rat brain. Six specific rabbit antibodies A (SS-14), B (SS-28), C (SS-28 complete), D (SS 14 and SS-28 both), E (SS preprohormone) and F (GHRH) were used for immunostaining using Avidin-Biotin Co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03164-4
更新日期：2001-05-11 00:00:00
abstract：:The roles of endogenous serotonin (5-HT) and 5-HT receptor subtypes in regulation of acetylcholine (ACh) release in frontal cortex of conscious rats were examined using a microdialysis technique. Systemic administration (1 and 3 mg/kg, i.p.) of the 5-HT-releasing agent p-chloroamphetamine (PCA) elevated ACh output in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00856-1
更新日期：1997-10-24 00:00:00
abstract：:It has been accepted that the descending system from the nucleus locus coeruleus (LC)/nucleus subcoeruleus (SC) plays a significant role in spinal nociceptive processing. The present study was designed to examine modulation of nociceptive processing in the caudal part of the trigeminal sensory nuclear complex, the tri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.023
更新日期：2003-12-12 00:00:00
abstract：:Two myelin sheaths sharing a common outer tongue process are illustrated in a thin section electron micrograph from mouse optic nerve. Although they derive from the same outer tongue process, and therefore from the same oligodendrocyte, the two sheaths are of different thicknesses (6 and 9 turns). The example demonstr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90712-6
更新日期：1983-09-12 00:00:00
abstract：:Excitatory amino acid neurotoxicity and the inflammatory response are suspected as mediators of some of the pathological sequelae occurring as a result of spinal cord injury. Here we report temporal and regional increases of the NMDA receptor agonist, quinolinic acid (QUIN), in an experimental model of spinal contusio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91560-1
更新日期：1994-01-07 00:00:00
abstract：:The occurrence of unmyelinated axons was examined ultrastructurally in rat molar and incisor root pulps of normal rats, of neonatally capsaicin-treated rats, of rats subjected to neonatal capsaicin treatment followed by resection of the superior cervical ganglion and of sympathectomized but otherwise normal rats. Foll...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90533-1
更新日期：1988-10-25 00:00:00
abstract：:Anesthetized Sprague-Dawley rats fitted with intracerebroventricular (i.c.v.) cannulas were infused with one of the aminopeptidase inhibitors, amastatin or bestatin, over a 5-min period. After infusion, 1-2 X 10(6) cpm of [125I]angiotensin II ([125I]AII) or [125I]angiotensin III ([125I]AIII) was injected through the s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91279-6
更新日期：1988-05-17 00:00:00
abstract：:The distribution of substance P (SP) immunoreactivity in the spinal nucleus of the rat trigeminal nerve and in the skin of the lower lip was examined following (a) unilateral electrolytic lesions of the trigeminal ganglion, (b) trigeminal rhizotomy, and (c) unilateral interruption of the mental nerve, the sensory bran...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)91105-8
更新日期：1978-09-08 00:00:00
abstract：:The effects of exo- and endogenous cGMP on the resting activity (RA) of afferent crista fibers were studied in isolated preparations of the statocysts of the cuttlefish Sepia officinalis and the squid Sepioteuthis lessoniana. Bath application of the membrane-permeable cGMP analogs 8-bromo-cGMP (B-cGMP) and N(2),2'-o-d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02777-3
更新日期：2000-10-13 00:00:00
abstract：:Inflammation and immune response have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Recently, increased TLR4 expression has been associated with the development of cerebral vasospasm in a rabbit model of SAH. Peroxisome proliferator-activated receptor gamma (PPARgamma) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.073
更新日期：2010-03-31 00:00:00
abstract：:Tacrolimus (FK506), a potent immunosuppressive drug, is effective in attenuating brain infarction after cerebral ischemia. However, there has been no report characterizing the neuroprotective action and therapeutic time window of tacrolimus systematically using different types of stroke models and extended observation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04151-3
更新日期：2003-03-07 00:00:00
abstract：:The developmental control of neuroblast proliferation is absolutely required for the assembly and function of the central nervous system. A lethal mutation in trol results in the failure of quiescent neuroblasts to begin division at the appropriate time. I have established a culture system in which quiescent neuroblas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01292-x
更新日期：1999-02-06 00:00:00
abstract：:The intermediate, medial part of the hyperstriatum ventrale (IMHV) is an area of the avian forebrain which is essential for two forms of early learning in the domestic chick. We have developed an in vitro slice preparation which contains part of the IMHV and have found that the electrophysiological properties of the a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00361-7
更新日期：1996-07-15 00:00:00
abstract：:The origin of the afferents of the thalamic anterior paraventricular and parataenial nuclei (PVA-PT) in the rat was studied with fluorescent retrograde tracing method. After iontophoretic application of Fluoro-Gold into PVA-PT, many labeled cells were found in the medial frontal cortex, ventral subiculum, claustrum, s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91570-7
更新日期：1990-07-02 00:00:00
abstract：:Monoamine oxidase A and B (MAO A and B; EC 1.4.3.4) are integral proteins of the outer mitochondrial membrane that degrade monoamines including the neurotransmitters norepinephrine, dopamine, and serotonin. In this study, monoclonal antibodies that recognize rat or monkey MAO A were used in immunocytochemical studies ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91664-e
更新日期：1993-05-28 00:00:00
abstract：:Serum-free aggregating cell cultures of fetal rat telencephalon grown in the presence of 3 ng/ml (5 X 10(-10) M) epidermal growth factor (EGF) until day 12 showed 2- to 3-fold increased activities in the two glial enzymes, glutamine synthetase (GLU-S) and 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase). This effe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90222-5
更新日期：1983-12-01 00:00:00
abstract：:A Rous Sarcoma virus transformed cerebellar cell line, BC6, secretes a factor which causes clonal glial cell lines to rapidly (1 h) extend processes. The factor shows a degree of specificity since only 3 out of 10 lines which exhibit either glial or combined glial and neuronal properties respond. The active factor app...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90214-6
更新日期：1983-12-01 00:00:00
abstract：:The primate somatosensory neuraxis provides a highly translational model system with which to investigate adult neural plasticity. Here, we report immunohistochemical staining data for AMPA and GABAA/B receptor subunits of area 3b cortex and cuneate nucleus of adult squirrel monkeys one to five years after median and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.03.010
更新日期：2015-06-22 00:00:00
abstract：:The luteinizing hormone-releasing hormone (LHRH) system of the platyfish Xiphophorus has been studied using immunohistochemistry and retrograde transport of horseradish peroxidase (HRP). Three different populations of LHRH-positive cell bodies are present in the brain, one in the ventral telencephalon at the border to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91059-3
更新日期：1981-09-21 00:00:00
abstract：:This paper reports studies on the biotransformation of the nonapeptide arginine-vasotocin (AVT) by both rat and chicken brain synaptic membranes. The fragments which were formed during digestion of AVT1-9, were isolated by high pressure liquid chromatography (HPLC) and chemically characterized by amino acid compositio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90419-5
更新日期：1983-09-19 00:00:00
abstract：:In this report, using a push-pull perfusion technique, we examined in vivo the effects of exogenous dopamine (DA) on the output of neurochemical substances from the caudate nucleus (CN) of freely behaving rats. Exogenous DA, at concentrations of 10(-5) M, 5 x 10(-5) M and 10(-4) M, in modified Krebs-Ringer phosphate m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90803-2
更新日期：1989-03-06 00:00:00
abstract：:The effects of undernutrition during pregnancy and/or lactation periods on cortical structures have already been reported. However, its effect on non-cortical areas like the hypothalamic, that participates in the regulation of the autonomic nervous system or food intake, has not been extensively investigated. We studi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91572-5
更新日期：1994-08-15 00:00:00
abstract：:One monoclonal antibody 115A10 (MAb 5A10) specifically stained a subpopulation of retinal bipolar cells in various vertebrates. In the bullfrog retina, MAb 5A10 stained the large bipolar cells, but not the small bipolar cells. Labeling of the living bipolar cells was observed in isolated cell preparation of the frog r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90919-x
更新日期：1987-07-28 00:00:00
abstract：:The effect of different steady-state cocaine concentration maintenance on the microdialysis extraction fraction of cocaine (in situ recovery; Ed) in the medial prefrontal cortex (mPFC) was examined. Male, adult Sprague-Dawley rats anesthetized with chloral hydrate were used. All rats were randomly divided into three g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00456-z
更新日期：1995-07-24 00:00:00
abstract：:A major role of tooth receptors in signaling overt or impending tissue damage (nociception) has been previously established by substantial evidence from mechanical, thermal and chemical stimulation of exposed dentin. We report evidence showing that some intradental receptors in canine teeth of the cat detect mechanica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90239-2
更新日期：1985-05-20 00:00:00
abstract：:Endogenous cytochrome oxidase activity within the mitochondria of neurons and neuropil was demonstrated histochemically under normal and experimental conditions. Since enzymatic changes were noted with chronic neuronal inactivity in the auditory system (Wong-Riley et al), the present study sought to examine functional...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90728-5
更新日期：1979-07-27 00:00:00
