Abstract:
:Enriched environment (EE) has been shown to have beneficial effects on cognitive recovery after brain injury. Typical EE comprises three components: (i) enlarged living area providing physical activation, (ii) sensory stimulation, and (iii) social stimulation. The present study assessed the specific contribution of the social stimulation. Animals were randomly divided into groups of (1) a typical EE, (2) pure social enrichment (SE), or (3) standard housing (SH) and subjected to either a sham operation or transection of the fimbria-fornix (FF). The effect of these conditions on acquisition of a delayed alternation task in a T-maze was assessed. The sham control groups were not affected by housing conditions. In the lesioned groups, both typical EE and SE improved the task acquisition, compared to SH. A baseline one-hour activity measurement confirmed an equal level of physical activity in the EE and SE groups. After delayed alternation testing, pharmacological challenges (muscarinergic antagonist scopolamine and dopaminergic antagonist SKF-83566) were used to assess cholinergic and dopaminergic contributions to task solution. Scopolamine led to a marked impairment in all groups. SKF-83566 significantly enhanced the performance of the lesioned group subjected to SE. The results demonstrate that housing in a typical as well as atypical EE can enhance cognitive recovery after mechanical injury to the hippocampus. The scopolamine challenge revealed a cholinergic dependency during task performance in all groups, regardless of lesion and housing conditions. The dopaminergic challenge revealed a difference in the neural substrates mediating recovery in the lesioned groups exposed to different types of housing.
journal_name
Brain Resjournal_title
Brain researchauthors
Gajhede Gram M,Gade L,Wogensen E,Mogensen J,Malá Hdoi
10.1016/j.brainres.2015.10.019subject
Has Abstractpub_date
2015-12-10 00:00:00pages
182-95eissn
0006-8993issn
1872-6240pii
S0006-8993(15)00763-5journal_volume
1629pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The localization of vasoactive intestinal peptide (VIP)-like immunoreactivity was investigated in the brain, olfactory system and retina of the zebrafish, Danio rerio, during development and in juvenile specimens, by using the indirect immunofluorescence and the peroxidase-antiperoxidase methods. In 24 h post fertiliz...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03065-1
更新日期:2001-01-12 00:00:00
abstract::Glutamate kills sensitive neurons through several steps downstream to receptor activation: increased free Ca2+ levels, activation of various enzymes and accumulation of reactive oxygen species (ROS). We have evaluated in a well established model of neuronal cultures the neuroprotective effects of blocking these mechan...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-07-22 00:00:00
abstract::Propofol (2,6-diisopropylphenol) is an intravenous general anaesthetic which can directly activate and positively modulate the GABAA receptor. The effects of propofol on human recombinant GABAA receptors were studied in Xenopus oocytes expressing either alpha1beta2, alpha1beta2gamma2L, or alpha2beta2gamma2L receptor i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01334-6
更新日期:1998-02-16 00:00:00
abstract::Males and females perform differently on a variety of training tasks. In the present study we examined performance of male and female rats while they were trained with a gross motor skill in which they learn to maintain their balance on an accelerating rotating rod (the accelerating rotarod). During training, many ani...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.11.045
更新日期:2015-09-24 00:00:00
abstract::Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is an essential component of membrane phosphatides and has been implicated in cognitive functions. Low levels of circulating or brain DHA are associated with various neurocognitive disorders including Alzheimer's disease (AD), while laboratory animals,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.08.089
更新日期:2007-11-28 00:00:00
abstract::Stimulation of cardiac sympathetic afferents evokes excitatory cardiovascular reflexes. However, the exact regions in the brain that integrate these reflexes have not been identified. Expression of c-Fos in the neurons provides a useful marker of the activated neurons. In the present study, we examined the response of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03259-0
更新日期:2002-01-18 00:00:00
abstract::Repeated administration of subconvulsant doses of lidocaine or cocaine results in the development of an increased susceptibility to seizures induced by the two drugs (pharmacological kindling). It has been hypothesized that the local anesthetic properties of cocaine are responsible for its convulsant and epileptogenic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90628-9
更新日期:1991-10-25 00:00:00
abstract::Neonatal rat superior cervical ganglia were mechanically dissociated, and the sympathetic neurons grown in dispersed cell cultures. Intracellular microelectrodes were used to study the effects of tetraethylammonium (TEA+), a blocker of outward K+ currents, on the excitable properties of these neurons. Addition of TEA+...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91234-4
更新日期:1984-02-20 00:00:00
abstract::A study was made of the effects of electrochemically stimulating (ECS) and destroying the midbrain dorsal and median raphe nuclei on the estrogen-progesterone- (EP) induced surge of pituitary LH release in ovariectomized rats. ECS and lesions were produced simultaneously with anodal direct current through a chronicall...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90006-8
更新日期:1981-08-03 00:00:00
abstract::The expression of the immediate-early gene c-fos was used as a marker of neuronal activity to investigate the cervical spinal interneuron populations involved in the corticomotoneuronal pathway. Adult rats received unilateral kainate injections in the forelimb area of the primary motor cortex. After a survival period ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00365-4
更新日期:1996-06-24 00:00:00
abstract::Both direct pituitary and indirect CNS mechanisms have been postulated for the influence of opiate agonists on prolactin secretion. By examining the interactions between terminals of neurons containing opioid peptides and hypothalamic TH-positive cell bodies, this paper addressed the anatomical basis for the latter me...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90338-a
更新日期:1992-05-22 00:00:00
abstract::The objective was to determine if corticopetal basal forebrain neurons could co-synthesize different transmitters. Histochemical labeling of a molecular marker of connectivity (wheat germ agglutinin lectin-bound horseradish peroxidase [HRP]; axonal uptake and retrograde transport from neocortex) and immunohistochemica...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90099-1
更新日期:1989-07-03 00:00:00
abstract::Effects of iontophoretically applied dopamine were investigated in prefrontal neurons of the monkey which showed activity changes during a visual reaction time task. The task consisted of an initial waiting phase (3.0 s), a warning phase (green lamp, 1.5-3.5 s), a lever-release GO phase (red lamp) and a reward phase. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90385-9
更新日期:1986-04-23 00:00:00
abstract::Short-latency afferent inhibition (SAI) and long-latency afferent inhibition (LAI) are well-known transcranial magnetic stimulation (TMS) paradigms used to probe the sensorimotor system. To date, there is a paucity of research examining the reliability of these neurophysiological measures. This information is required...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146394
更新日期:2019-11-15 00:00:00
abstract::Neuropeptide K (NPK), a member of the kassinin-like tachykinin family, is contained in the rat hypothalamus and is known to stimulate pituitary ACTH release. The intraperitoneal bolus administration of NPK dose-dependently enhanced corticosterone blood level not only in intact rats, but also in hypophysectomized/ACTH ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91185-1
更新日期:1994-10-24 00:00:00
abstract::The dopamine transporter from rat caudate-putamen was photolabeled with [125I]DEEP as previously described. Treatment of photolabeled membranes with neuraminidase and N-glycanase reduced the molecular weight of the [125I]DEEP photolabeled dopamine transporter complex, whereas treatment with alpha-mannosidase had no ef...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91627-d
更新日期:1991-01-25 00:00:00
abstract::Maternal cocaine abuse has several deleterious effects in the newborn, including perinatal asphyxia, hypoxia, and hypercapnia. We hypothesized that chronic cocaine exposure during development may alter cerebral blood flow (CBF) regulation. We studied 16 neonatal rabbits that had received cocaine (20 mg/kg, i.p. b.i.d....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00178-9
更新日期:1997-04-25 00:00:00
abstract::We investigated the bilateral organization of the descending spinal sympathetic projections that subserve adrenomedullary stimulation caused by insulin hypoglycemia or 2-deoxyglucose (2DG) cellular glucopenia in adult rats with right-sided hemisection of the cord at C6-C7 (i.e. above the site of origin of the adrenal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90315-4
更新日期:1985-01-28 00:00:00
abstract::Bcl-2 has been hypothesized to regulate many cellular functions in addition to its well-characterized role in the prevention of programmed cell death. To understand the role of Bcl-2 in regulating cell morphology and to explore the mechanism of this effect, we examined the effects of Bcl-2 overexpression on the morpho...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.07.017
更新日期:2006-09-27 00:00:00
abstract::Patches excised from fields CA1 and CA3 of the hippocampus were used to study AMPA receptor responses to repetitive application of brief pulses of agonist. AMPA receptors in field CA1 exhibited a larger degree of paired-pulse depression and a slower recovery rate from desensitization than those from CA3 patches. Respo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00030-3
更新日期:1996-04-15 00:00:00
abstract::The postnatal development of acetylcholinesterase (AChE, EC 3.1.1.7) and NADH-diaphorase was examined in the caudate-putamen nucleus and substantia nigra of rats ranging from 3 to 90 days in age. From 3 to 15 days post partum islands of AChE and NADH-diaphorase activity were observed in the caudate-putamen nucleus. In...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)91022-2
更新日期:1976-04-23 00:00:00
abstract::The impact of hyperglycemia after traumatic brain injury (TBI), and even the administration of glucose-containing solutions to head injured patients, remains controversial. In the current study adult male Sprague-Dawley rats were tested on behavioral tasks and then underwent surgery to induce sham injury or unilateral...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.04.022
更新日期:2015-07-21 00:00:00
abstract::Microspectrofluorimetric measurements of excitatory amino acid-evoked rises in intracellular free calcium concentration ([Ca2+]i), electrophysiological measurements of currents through single NMDA receptor-operated ion channels and estimates of cellular viability following NMDA challenge were employed to examine the i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00771-h
更新日期:1995-11-06 00:00:00
abstract::The effects of chronic treatment of rats with RWJ 37796, a novel aryl-piperazine containing antipsychotic drug, on brain monoamine receptors were studied. Rats were treated daily with RWJ 37796 (1.3 mg/kg), the typical antipsychotic haloperidol (1 mg/kg) or vehicle (control) for 21 days, and were sacrificed 3 days aft...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00155-j
更新日期:1995-04-24 00:00:00
abstract::Previous studies have shown that microinjection of morphine into the prefrontal ventrolateral orbital cortex (VLO) produces antinociception. The current study examined whether gamma-aminobutyric acid (GABA) containing neurons in the VLO were involved in this antinociception. Under light anesthesia, the GABA(A) recepto...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.067
更新日期:2006-02-16 00:00:00
abstract::Stroke-prone spontaneously hypertensive rats (SHRSP) are a well-characterized, genetic model for stroke. We showed earlier that the structure and function of the tight junctions in SHRSP blood-brain barrier endothelial cells is disturbed prior to stroke. To investigate the molecular events leading to endothelial dysfu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02670-1
更新日期:2001-08-10 00:00:00
abstract::A site-specific antibody against the principal gap junctional protein in heart (connexin 43) was used to determine immunohistochemically the cellular localization of this protein in rat brain. Structures labelled with the antibody included gap junctional membranes between glial, ependymal, pial and arachnoid cells as ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90415-8
更新日期:1990-02-05 00:00:00
abstract::β-Amyloid peptide (Aβ) plays a central role in the pathogenesis of Alzheimer׳s disease, but in lower amounts it is found in normal brains where it participates in physiological processes and probably regulates synaptic plasticity. This study investigated the effects of physiologically relevant concentrations of Aβ (1 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.02.031
更新日期:2014-04-16 00:00:00
abstract::Rat central nervous system (CNS) tissue sections were immunostained by the peroxidase-anti-peroxidase (PAP) method using a rabbit serum directed against rat liver 5'-nucleotidase. In paraffin sections from the brains of 60-day-old rats 5'-nucleotidase immunoreactivity occurred in the same white-matter regions as myeli...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90090-2
更新日期:1985-05-01 00:00:00
abstract::To determine the presence and distribution of cerebrovascular Abeta production we investigated amyloid beta precursor protein (AbetaPP)-mRNA expression by RNA in situ hybridization in patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type, Alzheimer disease and controls. In all subjects, AbetaPP-mRN...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01361-x
更新日期:1999-05-15 00:00:00