Abstract：
:The dopamine transporter from rat caudate-putamen was photolabeled with [125I]DEEP as previously described. Treatment of photolabeled membranes with neuraminidase and N-glycanase reduced the molecular weight of the [125I]DEEP photolabeled dopamine transporter complex, whereas treatment with alpha-mannosidase had no effect. The solubilized [125I]DEEP photolabeled dopamine transporter complex readily bound to wheat-germ agglutinin but not to concanavalin-A sepharose columns. These results suggest that the carbohydrate moiety of the dopamine transporter is N-linked and contains significant quantities of sialic acid but not high mannose residues. A DEEP binding protein was readily detectable in other brain regions including the nucleus accumbens and olfactory tubercle, but not in the prefrontal cortex, olfactory bulb or hypothalamus under similar conditions. The DEEP binding protein in the other brain regions was similar to that in the striatum.
journal_name
Brain Resjournal_title
Brain researchauthors
Lew R,Grigoriadis D,Wilson A,Boja JW,Simantov R,Kuhar MJdoi
10.1016/0006-8993(91)91627-dsubject
Has Abstractpub_date
1991-01-25 00:00:00pages
239-46issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91627-Djournal_volume
539pub_type
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