Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress.

Abstract:

:Early adverse events have been shown to increase the incidence of interstitial cystitis/painful bladder syndrome in adulthood. Despite high clinical relevance and reports of stress-related symptom exacerbation, animal models investigating the contribution of early life stress to female urological pain are lacking. We examined the impact of neonatal maternal separation (NMS) on bladder sensitivity and visceral neuroimmune status both prior-to, and following, water avoidance stress (WAS) in adult female mice. The visceromotor response to urinary bladder distension was increased at baseline and 8d post-WAS in NMS mice, while colorectal sensitivity was transiently increased 1d post-WAS only in naïve mice. Bladder micturition rate and output, but not fecal output, were also significantly increased following WAS in NMS mice. Changes in gene expression involved in regulating the stress response system were observed at baseline and following WAS in NMS mice, and WAS reduced serum corticosterone levels. Cytokine and growth factor mRNA levels in the bladder, and to a lesser extent in the colon, were significantly impacted by NMS and WAS. Peripheral mRNA levels of stress-responsive receptors were differentially influenced by early life and adult stress in bladder, but not colon, of naïve and NMS mice. Histological evidence of mast cell degranulation was increased in NMS bladder, while protein levels of protease activated receptor 2 (PAR2) and transient receptor potential ankyrin 1 (TRPA1) were increased by WAS. Together, this study provides new insight into mechanisms contributing to stress associated symptom onset or exacerbation in patients exposed to early life stress.

journal_name

Brain Res

journal_title

Brain research

authors

Pierce AN,Di Silvestro ER,Eller OC,Wang R,Ryals JM,Christianson JA

doi

10.1016/j.brainres.2016.02.039

subject

Has Abstract

pub_date

2016-05-15 00:00:00

pages

58-73

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(16)30098-1

journal_volume

1639

pub_type

杂志文章
  • Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice.

    abstract::The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90244-7

    authors: Heyman JS,Mulvaney SA,Mosberg HI,Porreca F

    更新日期:1987-09-08 00:00:00

  • Differential influence of posture and intentional movement on human somatosensory evoked potentials evoked by different stimuli.

    abstract::Somatosensory evoked potentials (SEP) recorded from humans were elicited by a cutaneous shock to the index finger or with a ramp displacement of the finger that stretched the first dorsal interosseous muscle. A somatosensory stimulus was presented while a subject maintained a steady posture of the metacarpophalangeal ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91068-8

    authors: Dimitrov B,Hallett M,Sanes JN

    更新日期:1989-09-04 00:00:00

  • Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus.

    abstract::Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is an essential component of membrane phosphatides and has been implicated in cognitive functions. Low levels of circulating or brain DHA are associated with various neurocognitive disorders including Alzheimer's disease (AD), while laboratory animals,...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.08.089

    authors: Sakamoto T,Cansev M,Wurtman RJ

    更新日期:2007-11-28 00:00:00

  • Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain.

    abstract::Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O(2)) or intermittent hypoxia (IH; 10% and ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.04.063

    authors: Li RC,Lee SK,Pouranfar F,Brittian KR,Clair HB,Row BW,Wang Y,Gozal D

    更新日期:2006-06-22 00:00:00

  • Macrophage invasion into injured cochlear nerve and its modification by methylprednisolone.

    abstract::Post-traumatic invasion of macrophages into the cochlear nerve of the rat and measurement of how their invasion was modified by the administration of methylprednisolone were investigated for the first time by using a reproducible and quantifiable experimental model of cochlear nerve injury. Two weeks after precise coc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02523-9

    authors: Sekiya T,Tanaka M,Shimamura N,Suzuki S

    更新日期:2001-06-29 00:00:00

  • Tryptophan hydroxylase mRNA levels are regulated by the circadian clock, temperature, and cAMP in chick pineal cells.

    abstract::Chick pineal cells contain a circadian oscillator that derives rhythmic synthesis and secretion of melatonin even in dispersed cell culture. Here, we demonstrate that the mRNA encoding tryptophan hydroxylase (TPH), the first enzyme in the melatonin synthetic pathway, is expressed rhythmically under the control of the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00743-3

    authors: Green CB,Besharse JC,Zatz M

    更新日期:1996-10-28 00:00:00

  • Delayed treatment with nicotinamide (vitamin B3) reduces the infarct volume following focal cerebral ischemia in spontaneously hypertensive rats, diabetic and non-diabetic Fischer 344 rats.

    abstract::Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo)....

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02263-1

    authors: Sakakibara Y,Mitha AP,Ayoub IA,Ogilvy CS,Maynard KI

    更新日期:2002-03-22 00:00:00

  • Identification of a 140 kDa protein of rat presynaptic terminal membranes encompassing the active zones.

    abstract::A polyclonal antiserum raised against the carboxy-terminal 17 amino acids of the rat p185c-neu (anct) reacted with a 140 kDa polypeptide in membranes of synaptosome fractions from neocortex and hippocampus of 11-day-old and adult rats. The same antiserum reacted with a 185 kDa polypeptide in microsome membranes from r...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00981-u

    authors: Stieber A,Chen Y,Gonatas J,Dougall W,Qian X,O'Rourke D,Samanta A,Greene MI,Gonatas NK

    更新日期:1995-11-27 00:00:00

  • Up-regulation of androgen receptor immunoreactivity in the rat brain by androgenic-anabolic steroids.

    abstract::To characterize central nervous system changes that occur with anabolic steroid abuse in humans, immunocytochemical localization of androgen receptors in the brains of 10 intact and 10 castrated male rats was conducted after the administration of high levels of androgenic-anabolic steroids (AAS; 14 daily injections of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90823-6

    authors: Menard CS,Harlan RE

    更新日期:1993-09-17 00:00:00

  • Visual modulation of proprioceptive reflexes during movement.

    abstract::Previous research has demonstrated that feedback circuits such as reflexes can be tuned by setting their gains prior to movement onset during both posture and movement tasks. However, such a control strategy requires that perturbation contingencies be predicted during movement planning and that task goals remain fixed...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.09.061

    authors: Mutha PK,Boulinguez P,Sainburg RL

    更新日期:2008-12-30 00:00:00

  • Environmental modulation of behavioral tolerance in spinal rats.

    abstract::We previously reported that the antinociceptive effect of morphine on the thermal tail withdrawal reflex (tail flick, TF) was reduced in rats that had practiced the TF response prior to morphine administration. This phenomenon, termed behavioral tolerance, was observed even when rats were spinally transected following...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90342-7

    authors: Advokat C,McInnis C

    更新日期:1992-05-22 00:00:00

  • Aging and neuropathic pain.

    abstract::Although chronic neuropathic pain disorders are more prevalent in the senescent population, little is known about how the aging process alters the thermal hyperalgesic sensitivity to peripheral nerve injury. In this study, neuropathic pain was induced in young, mature and aged FBNF1 hybrid rats via unilateral ligation...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01522-x

    authors: Novak JC,Lovell JA,Stuesse SL,Cruce WL,McBurney DL,Crisp T

    更新日期:1999-07-03 00:00:00

  • Sleep-awake responses elicited from medial preoptic area on application of norepinephrine and phenoxybenzamine in free moving rats.

    abstract::The study makes an attempt to find out the action of norepinephrine (NE) and phenoxybenzamine (PB), applied at medial preoptic area (mPOA), in altering the sleep-awake responses, in free moving rats, which has not yet been reported. Effects of application of NE during day and PB during night, at mPOA, on sleep-awake r...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90125-2

    authors: Mohan Kumar V,Datta S,Chhina GS,Gandhi N,Singh B

    更新日期:1984-11-26 00:00:00

  • Chronic intraventricular administration of lysergic acid diethylamide (LSD) affects the sensitivity of cortical cells to monocular deprivation.

    abstract::In kittens, but not in adult cats, depriving one eye of pattern vision by suturing the lids shut (monocular deprivation or MD) for one week reduces the proportion of binocular units in the visual cortex. A sensitivity of cortical units in adult cats to MD can be produced by infusing exogenous monoamines into the visua...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90424-3

    authors: McCall MA,Tieman DG,Hirsch HV

    更新日期:1982-11-04 00:00:00

  • Tetramethylpyrazine inhibits ATP-activated currents in rat dorsal root ganglion neurons.

    abstract::Tetramethylpyrazine (TMP) is one of the alkaloids contained in Ligustrazine which has been used in traditional Chinese medicine as an analgesic for injury and dysmenorrhea. ATP can elicit the sensation of pain. This study observed the effects of TMP on ATP-activated current (IATP) in rat DRG neurons. TMP (0.1-1 mM) co...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.01.076

    authors: Liang SD,Xu CS,Zhou T,Liu HQ,Gao Y,Li GL

    更新日期:2005-04-08 00:00:00

  • Prenatal exposure of rats to nicotine causes persistent alterations of nicotinic cholinergic receptors.

    abstract::We examined for immediate and persistent changes in nAChRs in cerebral cortex, thalamus and striatum of male rats caused by prenatal exposure to nicotine from gestational day 3 to postnatal day 10 (PN10), and how such exposure affected the responses of adolescents to subsequent nicotine challenge. Receptor numbers wer...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.10.076

    authors: Gold AB,Keller AB,Perry DC

    更新日期:2009-01-23 00:00:00

  • Effects of bicuculline on receptive field center sensitivity of relay cells in the lateral geniculate nucleus.

    abstract::The lateral geniculate nucleus (LGN) receives input from the retina that is spatially organized into a receptive-field center and surround. It maintains this organization in the signal that it sends to the visual cortex. Previous studies have focused on changes in the receptive-field 'surround' that are generated at t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90728-2

    authors: Norton TT,Holdefer RN,Godwin DW

    更新日期:1989-05-29 00:00:00

  • Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo.

    abstract::Infection and inflammation leading to injury or death of pre-oligodendrocytes (preOLs) is one of the principal initiating mechanisms in the pathogenesis of preterm periventricular leukomalacia (PVL). The present study explores the possible protective effect of curcumin against the toxicity of lipopolysaccharide (LPS)-...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.04.014

    authors: He LF,Chen HJ,Qian LH,Chen GY,Buzby JS

    更新日期:2010-06-21 00:00:00

  • Participation of Rel/NF-kappaB transcription factors in long-term memory in the crab Chasmagnathus.

    abstract::The induction of gene expression has been correlated with long-lasting neuronal plasticity and long-term memory (LTM) formation. The fast activation of constitutive transcription factors by signaling mechanisms is thought to be the link between synaptic events and gene expression. However, only one constitutive transc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02358-6

    authors: Freudenthal R,Romano A

    更新日期:2000-02-14 00:00:00

  • Slow rhythmic oscillations of EEG slow-wave amplitudes and their relations to midbrain reticular discharge.

    abstract::The amplitude of anterior neocortical EEG slow-waves (0.5-4 Hz) measured during quiet waking, drowsy (WS) and synchronized sleep (S) states showed slow rhythmic oscillations in WS and S similar to those previously reported in midbrain reticular neurons (periods of 8-12 s). Abrupt changes in slow rhythms of unit discha...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90153-1

    authors: Oakson G,Steriade M

    更新日期:1983-06-20 00:00:00

  • Calbindin (CaBP 28 kDa) appearance and distribution during development of the mouse inner ear.

    abstract::Previous reports of the distribution of calbindin, a 28 kDa vitamin D-induced calcium-binding protein, in the mammalian peripheral vestibular system postulated that this protein was involved in the calcium-dependent mechanisms occurring in the hair cells and ganglion cells. In this study, we examined the possibility o...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(88)90135-6

    authors: Dechesne CJ,Thomasset M

    更新日期:1988-05-16 00:00:00

  • The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging.

    abstract::Our previous studies have shown that there is a lower cGMP concentration in the aged brain as well as an alteration in the activity of cGMP-hydrolyzing phosphodiesterases (PDEs) and nitric oxide synthase (NOS). The aim of this study was to investigate the effect of specific inhibitors of selected PDEs on object recogn...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.02.108

    authors: Domek-Łopacińska K,Strosznajder JB

    更新日期:2008-06-24 00:00:00

  • The pattern of retinoic acid receptor expression and subcellular, anatomic and functional area translocation during the postnatal development of the rat cerebral cortex and white matter.

    abstract::Retinoic acid (RA), which is an important modulator of brain development, neural cell proliferation, neurite outgrowth, and synaptic plasticity, is regulated via changes in RA receptors. The pattern of RA receptor changes in the rat cerebral cortex and white matter during postnatal development has not been extensively...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.01.027

    authors: Jiang W,Wen EY,Gong M,Shi Y,Chen L,Bi Y,Zhang Y,Liu YF,Chen J,Qu P,Liu YX,Wei XP,Li TY

    更新日期:2011-03-25 00:00:00

  • Lentiviral-mediated overexpression of nerve growth factor (NGF) prevents beta-amyloid [25-35]-induced long term potentiation (LTP) decline in the rat hippocampus.

    abstract::We have explored the potential neuroprotective effect of local lentiviraly-mediated overexpression of nerve growth factor (NGF) on in vivo long-term potentiation (LTP) in the rat hippocampus under pathological conditions. The suspension of lentiviral particles was prepared using a genetic construct containing the huma...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.07.051

    authors: Uzakov SS,Ivanov AD,Salozhin SV,Markevich VA,Gulyaeva NV

    更新日期:2015-10-22 00:00:00

  • Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA.

    abstract::Antimitotic drugs used in the chemotherapeutic treatment of cancers induce undesirable but unavoidable side-effects from interruption of normal mitotic processes throughout the body. We have examined whether several such drugs capable of penetrating the blood-brain barrier - thioTEPA and 5-fluorouracil - influence the...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.06.093

    authors: Mignone RG,Weber ET

    更新日期:2006-09-21 00:00:00

  • Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats.

    abstract::Brain iron overload has a detrimental role in brain injury after intracerebral hemorrhage (ICH). Lipocalin 2 (LCN2), a siderophore-binding protein, is involved in cellular iron transport. The present study investigated changes in LCN2 expression after ICH and the role of iron in those changes. Male Sprague-Dawley rats...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.02.008

    authors: Dong M,Xi G,Keep RF,Hua Y

    更新日期:2013-04-10 00:00:00

  • Effects of low intensity radiofrequency electromagnetic fields on electrical activity in rat hippocampal slices.

    abstract::Slices of rat hippocampus were exposed to 700 MHz continuous wave radiofrequency (RF) fields (25.2-71.0 V m(-1), 5-15 min exposure) in a stripline waveguide. At low field intensities, the predominant effect on the electrically evoked field potential in CA1 was a potentiation of the amplitude of the population spike by...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02434-9

    authors: Tattersall JE,Scott IR,Wood SJ,Nettell JJ,Bevir MK,Wang Z,Somasiri NP,Chen X

    更新日期:2001-06-15 00:00:00

  • Macular input to neurons of the spinoreticulocerebellar pathway.

    abstract::The present report summarizes the results obtained in previous experiments in which the responses to lateral tilt of both reticulocerebellar neurons located in the lateral reticular nucleus (NRL) and ascending spinoreticular tract axons, located in the lateral funiculi of the cervical segments C2-C3, had been recorded...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(75)90112-2

    authors: Pompeiano O

    更新日期:1975-09-23 00:00:00

  • Involvement of nigrostriatal dopamine neurons in the contraversive rotational behavior evoked by electrical stimulation of the lateral hypothalamus.

    abstract::This experiment was conducted to determine if nigrostriatal dopamine (DA) neurons are necessary for the contraversive rotational behavior evoked by electrical stimulation in the lateral hypothalamus. Rats were tested daily for electrical stimulation-induced rotational behavior (ESRB) for 5 days, and then given an inje...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91508-2

    authors: Castañeda E,Robinson TE,Becker JB

    更新日期:1985-02-18 00:00:00

  • DIgLONs inhibit initiation of neurite outgrowth from forebrain neurons via an IgLON-containing receptor complex.

    abstract::IgLONs are a family of four GPI-anchored cell adhesion molecules that regulate neurite outgrowth, synaptogenesis and may act as tumour suppressor genes. IgLONs are thought to function as monomers or homodimers and we have proposed that IgLONs also act as heterodimeric complexes termed Dimeric IgLONs or DIgLONs. Here w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.12.028

    authors: Akeel M,McNamee CJ,Youssef S,Moss D

    更新日期:2011-02-16 00:00:00