Abstract：
:It has been suggested that the mechanism underlying the pain that occurs in patients with diabetic neuropathy may be similar to that mediating sympathetically maintained pain (SMP), such as occurs in patients with reflex sympathetic dystrophy. To evaluate this suggestion we have examined a model of diabetes mellitus, the streptozotocin-diabetic (STZ-D) rat, for features characteristic of SMP. We demonstrate that the decrease in nociceptive threshold observed in the STZ-D rat is not attenuated by chemical sympathectomy nor exacerbated by intradermal injection of norepinephrine (NE). In addition, the NE content is markedly decreased in the skin of the STZ-D rat. These results suggest that altered nociceptive thresholds associated with diabetic neuropathy are not sympathetically maintained.
journal_name
Brain Resjournal_title
Brain researchauthors
Ahlgren SC,Levine JDdoi
10.1016/0006-8993(93)90206-3subject
Has Abstractpub_date
1993-07-09 00:00:00pages
171-5issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)90206-3journal_volume
616pub_type
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