Abstract：
:In the present experiment we tested the hypothesis that early interference with noradrenaline transmission can have permanent consequences for brain function in adulthood. Neonatal depletion of noradrenaline by daily subcutaneous injections of clonidine results in supersensitivity to noradrenaline in adult hippocampal CA1 cells as shown in our previous microiontophoretic study. These findings were confirmed and extended here with dose-response curves. Furthermore, we tested whether this form of neonatal interference with noradrenaline also permanently affects long-lasting plasticity as revealed in kindling epileptogenesis in adulthood. The initiation of the epileptic activity after the kindling stimulation was significantly delayed in the clonidine-treated group, and all measured parameters of seizure expression tended to be retarded in comparison with saline-treated control rats. This indicates that noradrenaline supersensitivity induced by neonatal clonidine treatment retards kindling development in adulthood.
journal_name
Brain Resjournal_title
Brain researchauthors
Gorter JA,Kamphuis W,Huisman E,Bos NP,Mirmiran Mdoi
10.1016/0006-8993(90)91824-zsubject
Has Abstractpub_date
1990-12-03 00:00:00pages
62-6issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)91824-Zjournal_volume
535pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Myelin of several Caudata (Urodela) species appears to be unique in the fact that it lacks hydroxycerebrosides and hydroxysulfatides although it contains their non-hydroxy counterparts. Comparison of the nerve conduction velocities in the Urodeles Necturus (salamander) and Notophthalmus (newt) with that in a reptile, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90831-5
更新日期：1985-10-14 00:00:00
abstract：:Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but not in other region...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90667-0
更新日期：1986-01-15 00:00:00
abstract：:Inhibition of nitric oxide (NO) synthesis has been found to produce learning deficits in spatial tasks. Recent studies also suggest a regulatory effect of endogenous NO on hippocampal serotonin (5-HT) release and have shown that NO-synthase (NOS) inhibitors increased extracellular levels of serotonin (5-HT) in the rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03987-2
更新日期：2003-02-14 00:00:00
abstract：:The substance P content, glutamic acid decarboxylase and choline acetyltransferase activities and the level of [3H]diprenorphine binding were measured in various regions of the lumbar spinal cord of rats after unilateral section of the sciatic nerve or after dorsal rhizotomy. Sciatic nerve section produced a 75--80% d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90167-7
更新日期：1979-05-25 00:00:00
abstract：:The stimulatory effect of insulin-like growth factor I (IGF-I) on myelin basic protein (MBP) expression, a parameter for oligodendrocyte development, is mediated by the MAPK and PI3K signaling pathways. We have previously shown that the second messenger cAMP inhibits IGF-I-induced MAPK activation as well as MBP expres...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.018
更新日期：2007-10-31 00:00:00
abstract：:Chronically demyelinated lesions of cat dorsal columns were created by focal injection of the glial toxin ethidium bromide. Freeze-fracture studies show that the center of the lesion, which is devoid of glial cells and processes, contains axons having neither node-like nor paranodal-type membrane specializations. Near...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90973-4
更新日期：1985-12-09 00:00:00
abstract：:L-Tryptophan produces a significant antihypertensive effect in spontaneously hypertensive rats while D-tryptophan does not change blood pressure. Both isomers of tryptophan significantly increase brain serotonin to the same extent at a time when the antihypertensive effect of L-tryptophan is maximal. Thus, the antihyp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90985-5
更新日期：1984-03-19 00:00:00
abstract：:The hippocampal formation of the rat contains two types of membrane-bound cholinergic binding sites, as revealed by specific binding of [3H]quinuclidinyl benzilate (QNB) or of a-[125I]bungarotoxin (a-Btx). The sites differ in pharmacological profile, sensitivity to detergents and ontogenesis. The major binding site (a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90211-7
更新日期：1979-04-27 00:00:00
abstract：:In albino rats the superior colliculus was stimulated and evoked potentials were explored in the cerebellar hemisphere including the paramedian lobule, and crura I and II. Climbing fiber responses were identified in a strip (ca. 1 mm wide) in the medial region of crus II, extending to both folia a and b. In the tector...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90304-5
更新日期：1986-07-16 00:00:00
abstract：:We assessed the application of a replication deficient recombinant adenovirus vector as a retrograde tracer in neural pathway studies. The adenovirus vector, Ad. RSV betagal, containing the intracellular marker gene, beta-galactosidase, was injected directly into the laterodorsal striatum of rats. The retrograde trans...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01065-3
更新日期：1995-12-24 00:00:00
abstract：:The effects of postnatal thyroidectomy (on day 8 after birth) and 131I treatment (on day 10) on the development of the vomeronasal organ (VO) has been studied In the rat. Thyroidectomized rats showed decrements in the overall VO volume, volume of the neurosensorial epithelium, neuronal population and nuclear size of n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90159-6
更新日期：1982-10-01 00:00:00
abstract：:An investigation has been carried out into the physiological properties of tendon organs and their interactions with motor units following two types of nerve injury: nerve crush and nerve transection followed by suture repair. Recovery from nerve crush was very successful: 6 weeks after the injury 60% of the tendon or...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00847-j
更新日期：1995-10-30 00:00:00
abstract：:Chronic vitamin B12 (cobalamin) deficiency in the mammalian central nervous system causes degenerative damage, especially in the spinal cord. Previous studies have shown that cobalamin status alters spinal cord expression of epidermal growth factor (EGF) and its receptor in rats. Employing a mouse model of cobalamin-d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.01.050
更新日期：2013-03-29 00:00:00
abstract：:The properties of [3H]dihydropyridine (DHP), nitrendipine and (+)-PN 200-110, binding to rat cerebral membranes were investigated. In normotensive Wistar-Kyoto (WKY) adult rats, the highest densities of [3H]DHP binding sites were found in the hippocampus. Frontal cerebral cortex and hypothalamus had intermediate level...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91446-6
更新日期：1987-05-26 00:00:00
abstract：:Electrical stimulation of the dorsal hippocampal formation of the rat was employed to determine the effect of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), the hormonal form of vitamin D, on induced seizure thresholds. Stereotaxic injection of 100 micrograms or 50 micrograms 1,25-dihydroxyvitamin D3 in 2 microliter propyle...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91153-3
更新日期：1984-04-23 00:00:00
abstract：:Changes in the partial pressure of arterial CO2 (PaCO2) regulates cerebrovascular tone and dynamic cerebral autoregulation (CA). Elevations in PaCO2 also increases autonomic neural activity and may alter the arterial baroreflex. We hypothesized that hypercapnia would impair, and hypocapnia would improve, dynamic CA an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.07.048
更新日期：2008-09-16 00:00:00
abstract：:The development of spontaneous activity in response to morphine administration was studied at different postnatal ages in C57BL/6 mice. Morphine induced hyperactivity at all ages except in 3-week-old mice, in which a catatonic effect is evident. The results indicate that the neurophysiological and inhibitory systems r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90029-8
更新日期：1981-11-01 00:00:00
abstract：:We investigated the localization of components of translational machinery and their regulators in the postsynaptic region. We examined several components, especially those involved in translational regulation: components of (1) MAPK-Mnk-eIF4E, (2) PI3-kinase-PDK-Akt/PKB-FRAP/mTOR-PHAS/4EBP, (3) p70S6K-S6 ribosomal pro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02523-x
更新日期：2003-05-16 00:00:00
abstract：:We have previously found that crocin (crocetin di-gentiobiose ester) antagonizes the inhibitory effect of ethanol on long-term potentiation in the rat hippocampus in vivo and in vitro. To explore mechanisms underlying the antagonism of crocin against ethanol, we investigated the effects of ethanol and crocin on synapt...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01505-9
更新日期：1998-03-16 00:00:00
abstract：:Dissociated 4-day (stage 23) chick embryo lumbar cord cells were cultured at low or high cell densities for 1 or 5 days in the presence or absence of added spinal neuronotrophic factor (supplied as RN22 Schwannoma conditioned medium, RCM). In low density, 1-day cultures neuronal survival was dependent on added RCM whe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91039-9
更新日期：1983-05-09 00:00:00
abstract：:In adult cats, we have investigated how nerve cross-union between slow and fast muscle affects twitch contraction and half-relaxation times in the presence and absence of motor disuse, produced by complete decerebellation. Cerebellectomy abolished the slowing of cross-innervated fast muscle and diminished the amount o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90480-2
更新日期：1982-02-18 00:00:00
abstract：:This study tested the hypothesis that the short-latency excitation of the phrenic motor output elicited by superior laryngeal nerve (SLN) stimulation requires non-NMDA receptor-mediated neurotransmission in the region of the dorsal respiratory group (DRG) of the adult cat. Injection of the non-NMDA receptor antagonist...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00355-t
更新日期：1995-06-05 00:00:00
abstract：:Available evidence suggests that a portion of the septohippocampal pathway may form inhibitory synapses on inhibitory interneurons in the dentate gyrus. In contrast, a portion of the commissural input from the contralateral hilus may form excitatory synapses on inhibitory interneurons. To ascertain whether these pathw...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90301-5
更新日期：1987-03-10 00:00:00
abstract：:A cluster of trigeminal nociceptive neurons was located in the lateral sulcus on the upper bank of the frontoparietal operculum in a region bordering between cortical areas SII and 7b. These neurons were isolated in cortical cell layers IV and V-VI. All nociceptive neurons responded exclusively to noxious mechanical s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90375-2
更新日期：1989-04-10 00:00:00
abstract：:Astrocytes exhibit an important role in neural lipid metabolism for the regulation of energy balance to supply fatty acids (FAs) and ketone bodies to other neural cells. Lipid droplets (LDs) consisting of neutral- and phospho-lipids increase in the brains of patients with neurodegenerative diseases, such as Alzheimer'...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146484
更新日期：2019-12-15 00:00:00
abstract：:Potassium-evoked cholecystokinin (CCK) release from slices of caudate-putamen and cerebral cortex, but not hippocampus incubated in vitro was increased by 152-175% by preincubation for 40 min with 10 mM lithium. These results and previous studies suggest that although different physiological agents regulate CCK releas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91030-4
更新日期：1987-06-16 00:00:00
abstract：:The development of symptomatic epilepsy is a model of long-term plasticity changes in the central nervous system. The rat pilocarpine model of epilepsy was utilized to study persistent alterations in calcium/calmodulin-dependent kinase II (CaM kinase II) activity associated with epileptogenesis. CaM kinase II-dependen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02623-8
更新日期：2000-09-01 00:00:00
abstract：:Environmental stressors can substantially affect the adaptive response of rats to novelty in a sexually dimorphic manner. Gender-related differences are also observed in neurochemical and behavioural patterns of adult rats following prenatal exposure to diazepam (DZ). In the present study the behavioural reactivity to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02462-3
更新日期：2001-06-22 00:00:00
abstract：:Studies with radioactive antipyrene and deoxyglucose indicated that both blood flow and metabolism are enhanced in the goldfish optic tectum following a brief visual stimulation. It is concluded that the brain of cold-blooded animals demonstrates regionally regulated physiological alterations, previously reported only...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90195-1
更新日期：1979-01-26 00:00:00
abstract：:The present study sought to determine if axonal connectivity is established between 6-month-old neostriatal transplants and the host substantia nigra. Cell suspensions of fetal neostriatum were transplanted into the adult rat neostriatum lesioned previously by kainic acid. Horseradish peroxidase injections into the ip...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91256-0
更新日期：1989-01-09 00:00:00
