Saccadic eye movement deficits in the MPTP monkey model of Parkinson's disease.

abstract：:Sprague-Dawley rats were submitted to bilateral ventral hippocampus lesions 7 days after birth according to the Lipska and Weinberger's procedure for modeling schizophrenia. The aim of the present work was to better characterize their learning capacity. A double latent inhibition study was conducted using respectively...

journal_title：Brain research

authors： Angst MJ,Macedo CE,Guiberteau T,Sandner G

更新日期：2007-04-27 00:00:00

abstract：:Glioblastoma is the most aggressive form of gliomas and is associated with short survival. Recent advancements in molecular genetics resulted in the identification of glioma genomic, epigenomic and transcriptomic hallmarks, and multidimensional data allowed clustering of glioblastomas into molecular subtypes. Parallel...

journal_title：Brain research

authors： Nagy A,Eder K,Selak MA,Kalman B

更新日期：2015-01-21 00:00:00

abstract：:Kindling is an experimental model for epilepsy in which repeated stimuli induce longer electrographic seizures and eventually cause behavioral convulsions. Although kindling has some features that are similar to chronic human epilepsy, it is not known whether this process plays a role in the development of chronic sei...

journal_title：Brain research

authors： Bertram EH,Cornett J

更新日期：1993-10-22 00:00:00

abstract：:Progestin-concentrating neurons in the preoptic area and hypothalamus that project to the midbrain in the female rat were identified using the combined steroid hormone autoradiography-retrograde axonal tracing technique. Progesterone target neurons were most abundant in the periventricular preoptic area and the medial...

journal_title：Brain research

authors： DonCarlos LL,Morrell JI

更新日期：1990-06-25 00:00:00

abstract：:Quantitative [125I]protein G-based immunohistochemistry was used to map the distribution of beta1 thyroid hormone receptor (TRbeta1) in normal and thyroidectomized adult rat brain, using a previously characterized polyclonal antibody. The distribution of TRbeta1-like immunoreactivity in normal brain was largely but no...

journal_title：Brain research

authors： Nobrega JN,Raymond R,Puymirat J,Belej T,Joffe RT

更新日期：1997-06-27 00:00:00

abstract：:Extracellular levels of acetylcholine (ACh) were measured in the central nucleus of the amygdala using microdialysis in 20-min intervals before, during, and after 1 h feeding in food-deprived rats. The results were compared to the effects of peripheral injections of glucose or 'low' (200 mU) and 'high' (1 U) doses of ...

journal_title：Brain research

authors： Hajnal A,Pothos EN,Lénárd L,Hoebel BG

更新日期：1998-02-23 00:00:00

abstract：:Gaze processing was investigated using event-related potentials in two different tasks in which front-view and 3/4-view faces were presented, with eyes gazing straight ahead or averted. Task alternated between an explicit gaze direction judgment and a judgment on head orientation where gaze was irrelevant. Accuracy an...

journal_title：Brain research

authors： Itier RJ,Alain C,Kovacevic N,McIntosh AR

更新日期：2007-10-26 00:00:00

abstract：:The outer plexiform layer (OPL) of the retina has been studied in the developing cat, from E (embryonic day) 30. Prior to E51 the layer could not be detected, the retina comprising two cell layers, an inner layer which becomes the ganglion cell layer of the adult, and an outer 'neuroblast' layer. The OPL was first det...

journal_title：Brain research

authors： Rapaport DH,Stone J

更新日期：1982-11-01 00:00:00

abstract：:The VIIIth cranial nerve projections in the hagfish, which has only one circular canal in the ear, were studied by transganglionic HRP transport. This nerve has two branches, the nervus utricularis (N. utr.) and the nervus saccularis (N. sac.), each with its own ganglion, the ganglion utriculare (G. utr.) and the gang...

journal_title：Brain research

authors： Amemiya F,Kishida R,Goris RC,Onishi H,Kusunoki T

更新日期：1985-06-24 00:00:00

abstract：:The choroid plexus epithelium constitutes the structural basis of the blood-cerebrospinal fluid barrier. We previously demonstrated that Streptococcus suis (S. suis), a relevant cause of bacterial meningitis in pigs and humans, affects porcine choroid plexus epithelial cell (PCPEC) barrier function and integrity. We n...

journal_title：Brain research

authors： Tenenbaum T,Essmann F,Adam R,Seibt A,Jänicke RU,Novotny GE,Galla HJ,Schroten H

更新日期：2006-07-19 00:00:00

abstract：:Noxious stimulation of the leg increases hind limb blood flow (HBF) to the ipsilateral side and decreases to the contralateral in rat. Whether or not this asymmetrical response is due to direct control by sympathetic terminals or mediated by other factors such as local metabolism and hormones remains unclear. The aim ...

journal_title：Brain research

authors： Korim WS,McMullan S,Cravo SL,Pilowsky PM

更新日期：2011-05-19 00:00:00

abstract：:The distribution of NK(1) receptor immunoreactivity in the amygdaloid complex, induction of NK(1) receptor endocytosis in the amygdala following immobilisation stress, and the ability of pretreatment with the substance P antagonist L-760,735 or imipramine to block this response were examined in gerbils, a species with...

journal_title：Brain research

authors： Smith DW,Hewson L,Fuller P,Williams AR,Wheeldon A,Rupniak NM

更新日期：1999-11-27 00:00:00

abstract：:Glia represents the most numerous group of nervous system cells and CNS development and function depend on glial cells. We developed a purified Muller glia culture to investigate the expression of several neurotransmitter markers on these cells, such as dopaminergic, cholinergic, GABAergic and peptidergic receptors or...

journal_title：Brain research

authors： Kubrusly RC,da Cunha MC,Reis RA,Soares H,Ventura AL,Kurtenbach E,de Mello MC,de Mello FG

更新日期：2005-03-21 00:00:00

abstract：:During retinal development, common precursors give rise to various types of cells in a time course specific to each cell type. Previously, we demonstrated that the bHLH gene Hes1 inhibits neuronal differentiation whereas, in Hes1-null retina, precursors prematurely differentiate into neurons and form abnormal rosette-...

journal_title：Brain research

authors： Takatsuka K,Hatakeyama J,Bessho Y,Kageyama R

更新日期：2004-04-09 00:00:00

abstract：:The delay associated with cerebral processing time implies a lack of real-time representation of changes in the observed environment. To bridge this gap for motor actions in a dynamical environment, the brain uses predictions of the most plausible future reality based on previously provided information. To optimise th...

journal_title：Brain research

authors： Beudel M,Leenders KL,de Jong BM

更新日期：2016-12-01 00:00:00

abstract：:In pentobarbitone-anesthetized cats, the spike sequences of dorsal horn neurons were recorded in response to random stimulation of branches of the suralis nerve. Combined frequency- and time-domain analysis was performed on the stimulus and spike trains. Coherence function estimates computed by spectral analysis were ...

journal_title：Brain research

authors： Kuipers U,Laouris Y,Kokkoroyiannis T,Meyer-Lohmann J,Windhorst U

更新日期：1988-10-11 00:00:00

abstract：:Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O(2)) or intermittent hypoxia (IH; 10% and ...

journal_title：Brain research

authors： Li RC,Lee SK,Pouranfar F,Brittian KR,Clair HB,Row BW,Wang Y,Gozal D

更新日期：2006-06-22 00:00:00

abstract：:The firing patterns of up to 4 concurrently active masseter motor units were studied with intramuscular electrodes during a continuous isometric contraction of 15 min duration, in which the subject maintained the mean firing rate of one selected unit at 10 Hz. With this paradigm the net excitation (i.e. mean firing ra...

journal_title：Brain research

authors： Nordstrom MA,Miles TS

更新日期：1991-05-24 00:00:00

abstract：:The ultrastructural features of the serotoninergic innervation of the rat dentate gyrus in normal adults and in animals receiving raphe nuclear area transplants was investigated using an antibody to serotonin (5-HT). Neonatal rats received a lesion of the fimbria-fornix and entorhinal cortex. Three days later, a porti...

journal_title：Brain research

authors： Anderson KJ,Holets VR,Mazur PC,Lasher RS,Cotman CW

更新日期：1986-03-26 00:00:00

abstract：:Stimulation of a region within the parvocellular medullary reticular formation (PcRF) that contains somas of premotor interneurons produces short latency inhibitory synaptic potentials (IPSPs) in cat trigeminal motoneurons. The present study was undertaken to determine whether glycinergic synapses are responsible for ...

journal_title：Brain research

authors： Castillo P,Pedroarena C,Chase MH,Morales FR

更新日期：1991-12-20 00:00:00

abstract：:There is evidence that heme oxygenase plays a role in cellular defense against reactive oxygen species and thereby has neuroprotective effects. We examined the interaction of Neotrofin, a cognitive-enhancing and neuroprotective drug, with the heme oxygenase system. In adult rats, both a single administration or seven ...

journal_title：Brain research

authors： Wang X,Hauptmann N,Taylor E,Foreman M,Khawli LA,Maines MD

更新日期：2003-02-07 00:00:00

abstract：:Brief force perturbations were applied 30-120 ms prior to onset of step-tracking forearm movements by normal humans. The perturbations altered the first agonist burst of the movement-related triphasic EMG pattern. Perturbations opposing the movement resulted in an increase in the magnitude of the late part of the firs...

journal_title：Brain research

authors： Brown SH,Cooke JD

更新日期：1981-09-14 00:00:00

abstract：:The acute stroke phase is a critical time frame used to evaluate stroke severity, therapeutic options, and prognosis while also serving as a major tool for the development of diagnostics. To further understand stroke pathophysiology and to enhance the development of treatments, our group developed a translational pig ...

journal_title：Brain research

authors： Kaiser EE,Waters ES,Fagan MM,Scheulin KM,Platt SR,Jeon JH,Fang X,Kinder HA,Shin SK,Duberstein KJ,Park HJ,West FD

更新日期：2020-06-01 00:00:00

abstract：:The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion. In comparison with the control group, indomethacin sig...

journal_title：Brain research

authors： Phillis JW,Smith-Barbour M,Perkins LM,O'Regan MH

更新日期：1994-08-01 00:00:00

abstract：:Picrotoxin-induced epileptiform activity was examined in neocortical slices prepared from 8- to 15-day-old rats. This activity consisted of spontaneous bursts of 3-5 discharges that resembled interictal spikes and were interspersed with ictal-like paroxysms lasting 10-30 s. Measurements of extracellular potassium ([K+...

journal_title：Brain research

authors： Hablitz JJ,Heinemann U

更新日期：1987-12-01 00:00:00

abstract：:Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...

journal_title：Brain research

authors： Baptista T,Araujo de Baptista E,Ying Kin NM,Beaulieu S,Walker D,Joober R,Lalonde J,Richard D

更新日期：2002-12-06 00:00:00

abstract：:Endogenous calcitonin was altered in rats by thyroparathyroidectomy, followed by supplementation with thyroxine and calcium. As a result, a reduction in the content of 5-hydroxytryptamine in the brain together with an increase in the concentration of tryptophan in the plasma were observed. The changes were accompanied...

journal_title：Brain research

authors： Nakhla AM,Latif A

更新日期：1982-04-29 00:00:00

abstract：:Alterations in brain high energy phosphate compounds, using 31P-NMR (nuclear magnetic resonance) spectroscopy, were measured in vivo in young adult (3-4 months) rats following prenatal exposure to ligands acting specifically at benzodiazepine (BDZ) binding sites. The exposure induced a decrease in intracellular pH tha...

journal_title：Brain research

authors： Miranda R,Ceckler T,Guillet R,Kellogg C

更新日期：1990-01-01 00:00:00

abstract：:Neurotransmitter effects were studied on in vitro release of immunoreactive somatostatin (SRIF) from slices prepared from several regions of the rat brain: mediobasal hypothalamus (MBH), preoptic anterior hypothalamic area (POA) and amygdaloid complex (AMY). Potassium (K+, 56 mM) stimulated SRIF release in all structu...

journal_title：Brain research

authors： Epelbaum J,Tapia-Arancibia L,Kordon C

更新日期：1981-06-29 00:00:00

abstract：:The activities of tyrosine hydroxylase and dopamine-beta-hydroxylase were measured in the medial basal hypothalamus and remaining hyothalamic tissue of female rats at various times during diestrus 2, proestrus and estrus. Tyrosine hydroxylase activity in the medial basal hypothalamus was significantly lower at 12.00 h...

journal_title：Brain research

authors： Carr LA,Voogt JL

更新日期：1980-09-08 00:00:00