Abstract：
:The delay associated with cerebral processing time implies a lack of real-time representation of changes in the observed environment. To bridge this gap for motor actions in a dynamical environment, the brain uses predictions of the most plausible future reality based on previously provided information. To optimise these predictions, adjustments to actual experiences are necessary. This requires a perceptual memory buffer. In our study we gained more insight how the brain treats (real-time) information by comparing cerebral activations related to judging past-, present- and future locations of a moving ball, respectively. Eighteen healthy subjects made these estimations while fMRI data was obtained. All three conditions evoked bilateral dorsal-parietal and premotor activations, while judgment of the location of the ball at the moment of judgment showed increased bilateral posterior hippocampus activation relative to making both future and past judgments at the one-second time-sale. Since the condition of such 'real-time' judgments implied undistracted observation of the ball's actual movements, the associated hippocampal activation is consistent with the concept that the hippocampus participates in a top-down exerted sensory gating mechanism. In this way, it may play a role in novelty (saliency) detection.
journal_name
Brain Resjournal_title
Brain researchauthors
Beudel M,Leenders KL,de Jong BMdoi
10.1016/j.brainres.2016.10.010subject
Has Abstractpub_date
2016-12-01 00:00:00pages
204-211eissn
0006-8993issn
1872-6240pii
S0006-8993(16)30702-8journal_volume
1652pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Three groups of rats, one with amygdala lesions, one with hippocampal lesions and a control group were trained on a brightness discrimination task under one of three different conditions, enhancement of the negative cue, enhancement of the positive cue or a non-enhanced condition. Animals with amygdala lesions showed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90621-7
更新日期：1977-04-15 00:00:00
abstract：:Odorant-stimulated formation of cAMP in olfactory receptor neurons may mediate olfactory signal transduction. The response is short and desensitization occurs rapidly, possibly by induction of cyclic nucleotide phosphodiesterase (PDE) activity. Previously, we showed that two low Km PDEs regulate hydrolysis of cAMP in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91401-d
更新日期：1993-05-07 00:00:00
abstract：:In the companion study (Dev. Brain Res., 34 (1987) 223-233), we showed that a monocular injection of antibodies against ox large retinal ganglion cells produces a 53% (low concentration) to 82% (high concentration) loss of Y-cells in lateral geniculate nucleus (LGN) layers A and A1 that receive inputs from the antibod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90212-4
更新日期：1987-08-01 00:00:00
abstract：:Frontal and temporal sections of 4 normal human brains and 3 brains from patients with a diagnosis of Alzheimer-type dementia (ATD) were stained with Vicia villosa lectin conjugated to biotin to localize glycoproteins containing terminal N-acetylgalactosamine. These lectin binding sites were localized at the surface o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90416-2
更新日期：1989-09-25 00:00:00
abstract：:We previously reported that oral l-citrulline (l-Cit) administration antagonizes neuronal cell death in hippocampus following transient brain ischemia and that oral glutathione (GSH) administration prevents neuronal death through antioxidant activity. Here, we tested potential synergy of combined l-Cit and GSH adminis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.03.014
更新日期：2017-05-15 00:00:00
abstract：:Administration of sheep red blood cells (10(6) cells, i.p.) resulted in central norepinephrine (NE) and dopamine (DA) changes which corresponded with the time of the peak immune response. These amine variations, however, appeared to be specific to certain brain regions. The increased accumulation of the NE metabolite,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90117-e
更新日期：1991-08-23 00:00:00
abstract：:Dopamine (DA) and noradrenaline (NA) extracellular levels have been measured by microdialysis in the medial frontal cortex (MFC), nucleus accumbens (NAc) and caudate-putamen (CP) under baseline conditions in awake and halothane-anaesthetized rats, and after application of three types of stimuli which are likely to act...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90711-h
更新日期：1992-05-29 00:00:00
abstract：:Two neuropeptides reacting with antibodies directed against the C-terminal region of somatostatin 28(1-12) were purified to homogeneity from rat brain extracts. Amino acid analysis revealed that the larger peptide (8 kdaltons) consisted of 76 amino acids. Microsequencing established its aminoterminal structure as: Ala...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91394-5
更新日期：1984-10-08 00:00:00
abstract：:Activation of the immune system in response to either infection or lipopolysaccharide (LPS) produces neurophysiological, neuroendocrine and behavioral changes. Some of the physiological consequences of LPS are mediated by endogenous opioid peptides. The following studies were designed to characterize the effects of LP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91908-9
更新日期：1994-06-13 00:00:00
abstract：:Opioid modulation of ingestion includes general opioid antagonism of deprivation-induced water intake and intake of sucrose and saccharin solutions. Previous studies using selective subtype antagonists indicated that opioid effects upon deprivation-induced water intake occurred through the mu2 receptor and that opioid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91274-v
更新日期：1993-08-06 00:00:00
abstract：:7-Chlorokynurenic acid (7-Cl KYNA) has been reported to attenuate N-methyl-D-aspartate (NMDA) receptor functioning by a potent and selective inhibitory action mediated at the strychnine-insensitive glycine recognition site of the NMDA complex. Here we report that 7-Cl KYNA dose-dependently inhibits [3H]MK-801 binding ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91378-4
更新日期：1989-12-18 00:00:00
abstract：:The principal thalamic and hypothalamic structures implicated in mnemonic information processing are the mediodorsal nucleus of the thalamus, the pulvinar, anterior thalamus, and laterodorsal nucleus, the mamillary body, and the mamillothalamic tract and internal medullary lamina. Determining the contribution of an in...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0006-8993(88)91226-7
更新日期：1988-12-01 00:00:00
abstract：BACKGROUND:Sex-specific trajectories in white matter development during adolescence may help explain cognitive and behavioral divergences between males and females. Knowledge of sex differences in typically developing adolescents can provide a basis for interpreting sexual dimorphisms in abilities and actions. METHOD:...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.051
更新日期：2011-02-23 00:00:00
abstract：:Apoptosis has been shown to be induced by some pathological stimuli. MPP+ is a neurotoxin and an inducer of parkinsonism. When SH-SY5Y cells, human neuroblastoma cell line, were treated with MPP+, cell death estimated by lactate dehydrogenase (LDH) leakage assay occurred. The cell death was associated with the DNA fra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01120-x
更新日期：1995-12-18 00:00:00
abstract：:Intrinsic versus extrinsic determinants of age-related alterations in hippocampal noradrenergic transmission were investigated using intraocular allografts in rats. Three groups of animals were examined: young hippocampal transplants in young hosts, old transplants in old hosts and young transplants in old hosts. Post...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91507-2
更新日期：1989-01-30 00:00:00
abstract：:Biocytin, a naturally occurring low molecular weight analog of biotin, was evaluated as a neuroanatomical tract-tracing marker in the adult rat brain. Since it retains high-affinity binding to avidin, biocytin can be labelled with avidinylated visualization reagents. Iontophoretic or pressure injections resulted in fi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90281-3
更新日期：1989-09-18 00:00:00
abstract：:Retinoic acid (RA), which is an important modulator of brain development, neural cell proliferation, neurite outgrowth, and synaptic plasticity, is regulated via changes in RA receptors. The pattern of RA receptor changes in the rat cerebral cortex and white matter during postnatal development has not been extensively...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.027
更新日期：2011-03-25 00:00:00
abstract：:The effects of exo- and endogenous cGMP on the resting activity (RA) of afferent crista fibers were studied in isolated preparations of the statocysts of the cuttlefish Sepia officinalis and the squid Sepioteuthis lessoniana. Bath application of the membrane-permeable cGMP analogs 8-bromo-cGMP (B-cGMP) and N(2),2'-o-d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02777-3
更新日期：2000-10-13 00:00:00
abstract：:The immunocytochemical localization of the enzyme choline acetyltransferase (ChAT) was examined in the guinea pig organ of Corti to determine if both lateral and medial systems of efferents would show immunoreactive labeling for this specific enzyme marker of cholinergic neurons. Cochleae were also examined after lesi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90242-2
更新日期：1985-07-08 00:00:00
abstract：:In a previous study, male rats showed behavioural deficits after a single restraint stress but not after 5 daily restraint periods (i.e. adaptation had developed): female rats although less affected by single restraint failed to adapt over the same time course. This sex difference was associated with the male but not ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90476-3
更新日期：1988-08-23 00:00:00
abstract：:This report deals with the effect of substance P (SP) and capsaicin on blood pressure and heart rate after administration into different sites of the nucleus tractus solitarii (NTS) of urethane-anesthetized rats. Microinjection of SP at 6 different coordinates throughout the NTS showed 3 sites where SP administration ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90938-3
更新日期：1987-10-06 00:00:00
abstract：:In decerebrate rats, the responses of tilt-sensitive neurons in the lateral and descending vestibular nuclei were studied during constant velocity 10 degrees off-vertical axis rotations (OVAR) in the clockwise (VW) and counterclockwise (CCW) directions. Seventy three otolith-related units showed a sinusoidal position-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00687-l
更新日期：1995-09-25 00:00:00
abstract：:The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.058
更新日期：2007-01-12 00:00:00
abstract：:The benzomorphan sigma ligands, (+)-N-allylnormetazocine (NANM) and (+)-pentazocine, but not (+)-cyclazocine, stereospecifically stimulated dopamine synthesis in minces of rat corpus striatum by 15-23% over basal values at 0.1-1.0 microM. The effect of (+)-NANM and (+)-pentazocine was blocked by the reported sigma ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90159-s
更新日期：1991-08-23 00:00:00
abstract：:It has been hypothesised that the increased life span commonly observed in rodents that have had their diet restricted after weaning may be related to its effects on the anti-oxidant defence systems. However, undernutrition during the gestation and pre-weaning period is known to have long-term deleterious effects on a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.046
更新日期：2008-07-30 00:00:00
abstract：:Unilateral microinjections (0.20 microliter) of the excitatory amino acids (EAA), L-aspartate (ASP), D,L-homocysteate (DLH) or kainate (KA) were made into the midbrain of freely moving cats. Injections of DLH (20 nmol) or ASP (200 nmol) made within the midbrain periaqueductal grey matter (PAG) consistently elicited a ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91465-5
更新日期：1988-01-26 00:00:00
abstract：:cGMP was proposed to be the agent which directly opens the light-sensitive channel in Limulus ventral photoreceptors. However, the light-sensitive rhabdomeral-lobe (R-lobe) is not uniformly responsive to cGMP injection; that is, there are 'hot spots' of sensitivity. A potent phosphodiesterase which rapidly hydrolyses ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90094-c
更新日期：1991-06-28 00:00:00
abstract：:We examined ethanol's interactions with serotonin (5-HT) receptor-mediated [3H]5-HT high-affinity uptake by adult rat forebrain synaptosomes. The serotonergic transport mechanism was chosen because ethanol consumption patterns can be manipulated by serotonin receptors and uptake blockers. We report that a dose of etha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90060-9
更新日期：1991-03-29 00:00:00
abstract：:Freeze-fracture examination of nodes of Ranvier from adult rat optic nerve demonstrates the presence of astrocytic processes at the majority of nodes of Ranvier. Astrocytic processes often run along the entire length of the nodal gap, although they do not necessarily encircle the entire nodal circumference. The E- and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90919-3
更新日期：1984-08-06 00:00:00
abstract：:Extracellular ATP can influence cells via activation of P2X purinoceptors, the distribution of which can be altered in the central and peripheral nervous systems following injury or tissue damage. Here we have investigated the effect of a unilateral section of the cervical vagus nerve on the distribution of P2X(1), P2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02797-5
更新日期：2003-07-04 00:00:00
