Abstract：
:cGMP was proposed to be the agent which directly opens the light-sensitive channel in Limulus ventral photoreceptors. However, the light-sensitive rhabdomeral-lobe (R-lobe) is not uniformly responsive to cGMP injection; that is, there are 'hot spots' of sensitivity. A potent phosphodiesterase which rapidly hydrolyses cGMP was suggested to explain the existence of these 'hot spots'. To test this idea we injected ventral photoreceptors with hydrolysis-resistant cyclic nucleotide analogues. Whereas there can be a lack of a response to cGMP injection into the R-lobe, we find a reproducible depolarization upon R-lobe injection of hydrolysis-resistant cGMP analogues. Furthermore, the depolarization resulting from the injection of cGMP analogues does not require a rise in intracellular Ca2+, as it is not blocked by the Ca2+ buffer, BAPTA. Surprisingly, R-lobe injection of a hydrolysis-resistant cAMP analogue also depolarized ventral photoreceptors. Further work will be needed to resolve the role of cGMP in Limulus visual transduction.
journal_name
Brain Resjournal_title
Brain researchauthors
Feng JJ,Frank TM,Fein Adoi
10.1016/0006-8993(91)90094-csubject
Has Abstractpub_date
1991-06-28 00:00:00pages
291-4issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90094-Cjournal_volume
552pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Hirschsprung's disease (HSCR) is a congenital malformation characterized by the absence of enteric ganglia in the distal intestine and gut obstruction. Some HSCR patients also have associated neurological symptoms. We studied a rat model of HSCR, also known as spotting lethal (sl/sl) rat, which carries a spontaneous d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.03.024
更新日期：2016-07-01 00:00:00
abstract：:The drug 6-hydroxydopamine (6-OHDA) has been reported to reduce hypothalamic norepinephrine (NE) content after administration into the lateral ventricle without altering the dopamine content of tubero-infundibular neurons. Serum prolactin levels in male rats injected with 2 X 250 mug 6-OHDA were significantly higher t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90647-8
更新日期：1976-03-05 00:00:00
abstract：:(1)The brain stem of anaesthetized cats has been mapped between Horsley-Clark planes APO and P8.5 with electrical stimuli of low intensity in order to determine the areas which can produce excitatory of inhibitory influences on the spontaneously contracting, sympathetically denervated, urinary bladder. (2) Two inhibit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90865-4
更新日期：1982-02-25 00:00:00
abstract：:Recent studies have demonstrated the neuroprotective properties of the novel imidazoquinoline benzodiazepine receptor partial agonist, PNU-101017, in the gerbil forebrain ischemia model. The compound effectively reduces delayed post-ischemic (5 min bilateral carotid occlusion) hippocampal CA1 neuronal degeneration eve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00478-8
更新日期：1998-07-06 00:00:00
abstract：:Preconditioning-induced cellular adaptation is a new therapeutic strategy for ischemic stroke. This research aims to examine the role of peroxisome proliferator activated receptor (PPAR)-γ co-activator 1-α (PGC-1α) and hypoxia induced factor-1α (HIF-1α) in hypoxic preconditioning-induced protection. In this study, rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.01.059
更新日期：2012-04-04 00:00:00
abstract：:In neuronal cultures, glycogen synthase kinase 3(GSK3) is truncated at the N-terminal end by calpain downstream of activated glutamate receptors. However, the in vivo biological significance of that truncation has not been explored. In an attempt to elucidate if GSK3 truncation has a pathophysiological relevance, we h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.03.016
更新日期：2015-06-22 00:00:00
abstract：:The nucleus accumbens and ventral pallidum receive dopamine (DA) projections from the mesencephalon. Although DA inputs to the nucleus accumbens are implicated in both locomotion and reward processes, little is known of the behavioural significance of DA in the ventral pallidum. These studies examined the effects of D...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00633-7
更新日期：1998-09-14 00:00:00
abstract：:The pathogenic mechanisms of gene-environment interactions determining variability of human neurodevelopmental disorders remain unclear. In the two consecutive papers, we used the neonatal Borna disease virus (BDV) infection rat model of neurodevelopmental damage to evaluate brain pathology, monoamine alterations, beh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02723-3
更新日期：2002-07-19 00:00:00
abstract：:In the course of studies on the responsiveness of mediobasal hypothalamic neurons to the iontophoretic application of cortisol, it was found that positive currents applied to a sodium chloride (1 M) barrel alone, but not to a choline chloride (1 M) barrel, frequently increased the firing of these neurons. Subsequently...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91091-0
更新日期：1983-08-22 00:00:00
abstract：:The medial septal area has been implicated in the control of the magnocellular neurosecretory cells of the hypothalamus, and in particular, in the regulation of neurons secreting oxytocin. The present study investigated the hypothesis that this medial septal pathway originates in the subfornical organ. Brief electrica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01278-p
更新日期：1995-02-20 00:00:00
abstract：:In the adult central nervous system (CNS), GABA and glycine (Gly) are predominant inhibitory neurotransmitters, negatively regulating glutamatergic transmission. In the immature CNS, on the other hand, they act as trophic factors, mediating morphogenesis. In the present study, to investigate their involvement in axona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.01.048
更新日期：2012-03-29 00:00:00
abstract：:The sexually dimorphic nucleus of the preoptic area (SDN-POA) is the most striking structure displaying a morphological sex difference in the rat brain. A potentially homologous nucleus has been identified in the human hypothalamus. The objective of the present study was to pursue the putative homology of the rat and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01005-0
更新日期：1996-12-02 00:00:00
abstract：:With the use of [3H]p-aminoclonidine (PAC), alpha 2-adrenergic binding sites were mapped in the brain of the Japanese quail (Coturnix coturnix japonica). The sites were labeled with the use of in vitro quantitative autoradiography. Special attention was given to areas implicated in the control of sexually dimorphic re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90088-7
更新日期：1989-07-03 00:00:00
abstract：:Cross-sectional areas of the forebrain ventricles were measured from coronal sections in spontaneously hypertensive rats (SHRs) 4, 8, 12, 16, 21 and 56 weeks of age and in age-matched Wistar--Kyoto (WKY) and Sprague--Dawley (SD) normotensive rats. Progressive ventricular dilation and associated attrition of brain tiss...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90488-9
更新日期：1986-04-09 00:00:00
abstract：:We have examined the influence of reducing conditions on the activity of group-I or -II metabotropic glutamate receptors. In cultured cerebellar granule cells or in hippocampal slices, the reducing agent dithiothreitol (DTT) inhibited the stimulation of polyphosphoinositide (PPI) hydrolysis elicited by group-I mGlu re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02293-9
更新日期：2000-06-09 00:00:00
abstract：:In the companion study (Dev. Brain Res., 34 (1987) 223-233), we showed that a monocular injection of antibodies against ox large retinal ganglion cells produces a 53% (low concentration) to 82% (high concentration) loss of Y-cells in lateral geniculate nucleus (LGN) layers A and A1 that receive inputs from the antibod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90212-4
更新日期：1987-08-01 00:00:00
abstract：:The sublaminar binding profiles of (D-Ala-NMe-Phe-Gly-ol)-enkephalin (DAGO), (2-D-penicillamine), 5-D-penicillamine)-enkephalin (DPDPE), and dynorphin A(1-8) (DYN) were studied in the CA1 subfield and dentate gyrus of rat hippocampal formation. Binding was assayed on cryomicrotome sections using coverslip autoradiogra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91215-2
更新日期：1988-09-13 00:00:00
abstract：:Group-housed Sprague-Dawley (SD) rats exposed for 1 h to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT, a component of fox feces) did not display changes in hippocampal serotonin (5-HT) metabolism and [3H]5-HT reuptake, compared to water or butyric acid. Such an observation extended to isolated SD and Fischer 344 rats. W...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03944-6
更新日期：2003-01-24 00:00:00
abstract：:Carbonic anhydrase (CA) and cholinesterase (CE) histochemical staining of rabbit spinal nerve roots and dorsal root ganglia demonstrated that among the reactive myelinated axons, with minor exceptions, sensory axons were CA positive and CE negative whereas motor axons were CA negative and CE positive. The high specifi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90145-x
更新日期：1988-06-21 00:00:00
abstract：:The effects of dopamine D1 and D2 selective drugs on the responses evoked in accumbens neurons by stimulation of cortical afferents were studied in an in vitro brain slice preparation. The D2-specific antagonist sulpiride (1-10 microM) increased, whereas the D2 agonist quinpirole (1-20 microM) occasionally attenuated ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90263-1
更新日期：1994-01-14 00:00:00
abstract：:A study of seizure activity and neuronal cell death produced by intracerebroventricular kainic acid had suggested that seizures conveyed by the hippocampal mossy fibers are more damaging to CA3 pyramidal cells than seizures conveyed by other pathways. To test this idea, the effects of a unilateral mossy fiber lesion w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91171-c
更新日期：1990-03-26 00:00:00
abstract：:We sought to characterize regional heterogeneity of astrocytes using adrenergic receptor sites as cellular markers. Primary cultures made from 6 regions of neonatal rat brain consisted almost exclusively of astrocytes. Membranes from astrocytes cultured 1-3 weeks were prepared for radioligand binding assays of beta- a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91027-e
更新日期：1990-05-28 00:00:00
abstract：:Ibogaine, a naturally occurring iboga alkaloid, has been claimed to be effective in treating addiction to opioids and stimulants, and has been reported to inhibit morphine and cocaine self-administration in rats. However, ibogaine also has acute nonspecific side effects (e.g. tremors, decreased motivated behavior in g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00056-x
更新日期：1996-05-06 00:00:00
abstract：BACKGROUND AND PURPOSE:The present study analyzed whether administration of sulindac, a non-steroidal anti-inflammatory drug (NSAID) would prevent, attenuate or repair ischemia induced brain injury and reverse functional impairment in a focal ischemia model of stroke. METHODS:Male Sprague-Dawley rats (weight 250-300 g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.06.019
更新日期：2014-08-12 00:00:00
abstract：:We have analyzed the binding properties of the selective D3 receptor agonist [3H]PD 128907 in 120 days old rats. In tissue sections, we found high numbers of binding sites for [3H]PD 128907 both in the islands of Calleja and the caudate-putamen (Bmax values being 500 and 1000 fmol/mg protein, respectively). The KD val...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01138-5
更新日期：1999-03-20 00:00:00
abstract：:Interpretation of the cellular and molecular pathogenic basis of post-minimal traumatic brain injury is a significant clinical and scientific problem, especially due to the high prevalence of motor vehicle--and other accidents. Pathogenetic brain mechanisms following traumatic impact are usually investigated by using ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.032
更新日期：2007-01-26 00:00:00
abstract：:The effects of partial metabolic inhibition (induced by 2 h exposure to low concentrations of cyanide (NaCN)) on the glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-induced excitotoxicity and elevation of free cytoplasmic Ca2+ levels ([Ca2+]i) were studied in glucose-deprived pri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01123-2
更新日期：1998-01-01 00:00:00
abstract：:Spinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.039
更新日期：2005-03-21 00:00:00
abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) produces symptoms similar to idiopathic Parkinson's disease in primates. A metabolite of MPTP, MPP+ (1-methyl-4-phenylpyridinium), is actively accumulated by dopaminergic (DA) terminals and selectively destroys nigrostriatal DA neurons. The mechanism of this effect r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90616-6
更新日期：1988-12-20 00:00:00
abstract：:Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.05.023
更新日期：2018-08-01 00:00:00
