Excitation of Limulus photoreceptors by hydrolysis-resistant analogs of cGMP and cAMP.

Abstract:

:cGMP was proposed to be the agent which directly opens the light-sensitive channel in Limulus ventral photoreceptors. However, the light-sensitive rhabdomeral-lobe (R-lobe) is not uniformly responsive to cGMP injection; that is, there are 'hot spots' of sensitivity. A potent phosphodiesterase which rapidly hydrolyses cGMP was suggested to explain the existence of these 'hot spots'. To test this idea we injected ventral photoreceptors with hydrolysis-resistant cyclic nucleotide analogues. Whereas there can be a lack of a response to cGMP injection into the R-lobe, we find a reproducible depolarization upon R-lobe injection of hydrolysis-resistant cGMP analogues. Furthermore, the depolarization resulting from the injection of cGMP analogues does not require a rise in intracellular Ca2+, as it is not blocked by the Ca2+ buffer, BAPTA. Surprisingly, R-lobe injection of a hydrolysis-resistant cAMP analogue also depolarized ventral photoreceptors. Further work will be needed to resolve the role of cGMP in Limulus visual transduction.

journal_name

Brain Res

journal_title

Brain research

authors

Feng JJ,Frank TM,Fein A

doi

10.1016/0006-8993(91)90094-c

subject

Has Abstract

pub_date

1991-06-28 00:00:00

pages

291-4

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(91)90094-C

journal_volume

552

pub_type

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