Long-term potentiation is associated with increased [3H]AMPA binding in rat hippocampus.

Abstract:

:The location and nature of the changes underlying long-term potentiation (LTP) remain controversial issues. In this study, we tested the possibility that changes in binding properties of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA/quisqualate and N-methyl-D-aspartate (NMDA) subtype of glutamate receptors are associated with LTP. LTP was elicited in vivo by stimulation of the perforant pathway in anesthetized rats. One hour following stimulation the animals were sacrificed. We performed quantitative ligand binding autoradiography on frozen brain sections using [3H]AMPA and [3H]N-(1-(2-thienyl)cyclohexyl)-3,4-piperidine ([3H]TCP) to label the AMPA/quisqualate and the NMDA receptors, respectively. No changes in [3H]TCP binding were detected in any of the treatment groups. However, increases in [3H]AMPA binding were observed only in animals that exhibited LTP. These increases were bilateral and present in several subfields of the hippocampus and cortical areas. Administration of the NMDA receptor antagonist, ketamine, prior to tetanic stimulation prevented both the increase in binding and the induction of LTP. These results suggest that changes in the characteristics of AMPA/quisqualate receptors are a biochemical correlate of LTP.

journal_name

Brain Res

journal_title

Brain research

authors

Tocco G,Maren S,Shors TJ,Baudry M,Thompson RF

doi

10.1016/0006-8993(92)90767-4

subject

Has Abstract

pub_date

1992-02-28 00:00:00

pages

228-34

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(92)90767-4

journal_volume

573

pub_type

杂志文章
  • Trigeminal modulation of gustatory neurons in the nucleus of the solitary tract.

    abstract::Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02526-5

    authors: Boucher Y,Simons CT,Faurion A,Azérad J,Carstens E

    更新日期:2003-05-30 00:00:00

  • Neurotensin receptor localization by light microscopic autoradiography in rat brain.

    abstract::Neurotensin is a putative peptide neurotransmitter in the mammalian brain. The light microscopic localization of the neurotensin receptor has been carried out by the autoradiographic localization of [3H]neurotensin binding sites in slide-mounted tissue sections. Large variations in receptor distribution were found, ev...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90532-1

    authors: Young WS 3rd,Kuhar MJ

    更新日期:1981-02-16 00:00:00

  • Dopamine modulates neuronal activities related to motor performance in the monkey prefrontal cortex.

    abstract::Effects of iontophoretically applied dopamine were investigated in prefrontal neurons of the monkey which showed activity changes during a visual reaction time task. The task consisted of an initial waiting phase (3.0 s), a warning phase (green lamp, 1.5-3.5 s), a lever-release GO phase (red lamp) and a reward phase. ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90385-9

    authors: Sawaguchi T,Matsumura M,Kubota K

    更新日期:1986-04-23 00:00:00

  • Reversible blockade of PGO waves and concomitant modifications of thalamic unit activity in chronic cats.

    abstract::The reversible blockade of geniculate PGO waves was carried out by localized cooling of the ponto-geniculate pathways during paradoxical sleep in chronic cats. In parallel, long-term recordings of unit activity were performed in non-specific visuooculomotor thalamic structures where no PGO waves occurred. Blockade of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90341-9

    authors: Laurent JP,Rondouin G,Benita M,Jouvet M

    更新日期:1977-12-02 00:00:00

  • Effects on the growth of damaged ganglion cell axons after peripheral nerve transplantation in adult hamsters.

    abstract::After transplantation of autologous sciatic nerve segments into the retina of adult hamsters for 1-2 months, retrograde labelling with horseradish peroxidase demonstrated a population of ganglion cells situated peripheral to the graft. If an additional lesion was placed between the insertion of the graft and the optic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91203-5

    authors: So KF,Xiao YM,Diao YC

    更新日期:1986-07-02 00:00:00

  • Dystroglycan is involved in the activation of ERK pathway inducing the change of AQP4 expression in scratch-injured astrocytes.

    abstract::We previously reported that aquaporin 4 (AQP4) played a critical role in formation of brain edema and the altered expression of dystroglycan (DG) could relate with AQP4 expression after traumatic brain injury (TBI). However the mechanisms of this process remain unclear. DG was showed could act as a scaffold involved i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.146347

    authors: Zhang G,Ma P,Wan S,Xu J,Yang M,Qiu G,Zhuo F,Xu S,Huo J,Ju Y,Liu H

    更新日期:2019-10-15 00:00:00

  • Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats.

    abstract::Brain iron overload has a detrimental role in brain injury after intracerebral hemorrhage (ICH). Lipocalin 2 (LCN2), a siderophore-binding protein, is involved in cellular iron transport. The present study investigated changes in LCN2 expression after ICH and the role of iron in those changes. Male Sprague-Dawley rats...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.02.008

    authors: Dong M,Xi G,Keep RF,Hua Y

    更新日期:2013-04-10 00:00:00

  • Visualization of rat brain receptors for the neuropeptide, substance P.

    abstract::Biochemical analysis of the binding of [125I]Bolton-Hunter coupled substance P [( 125I]BH-SP) to slide-mounted sections of rat brain demonstrated that [125I]BH-SP labels a binding site with a structure-activity profile characteristic of a substance P receptor. Under optimized preincubation and incubation conditions, t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91009-6

    authors: Rothman RB,Herkenham M,Pert CB,Liang T,Cascieri MA

    更新日期:1984-08-20 00:00:00

  • GABA-receptor stimulation enhances norepinephrine-induced polyphosphoinositide metabolism in rat hippocampal slices.

    abstract::The effect of gamma-aminobutyric acid (GABA)receptor stimulation on norepinephrine (NE)-induced metabolism of polyphosphoinositides (PIPs) was studied in rat hippocampal slices. Inositol phosphates (IPs), PIPs, and phosphatidic acid were measured. NE induced formation of IPs and phosphatidic acid in a dose-dependent m...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90701-3

    authors: Corradetti R,Ruggiero M,Chiarugi VP,Pepeu G

    更新日期:1987-05-12 00:00:00

  • Rat brain hypothalamic and hippocampal monoamine and hippocampal beta-adrenergic receptor changes during pregnancy.

    abstract::The concentration of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites was measured in hypothalamic and hippocampal brain tissue obtained from non-pregnant, 15- or 20-day pregnant and 4-day postpartum rats. At 20 days of pregnancy, hypothalamic NA and DA concentrations were significantly decre...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90286-i

    authors: Glaser J,Russell VA,Taljaard JJ

    更新日期:1992-04-17 00:00:00

  • Release of luteinizing hormone-releasing hormone: interrelations between eicosanoids and catecholamines.

    abstract::The in vitro release of luteinizing hormone-releasing hormone (LHRH), prostaglandin (PG) E2 and leukotriene (LT) C4 from male rat median eminences (ME), was estimated by radioimmunoassay (RIA) in the presence of the catecholamines (CA), norepinephrine (NE) and dopamine (DA). NE increased the release of PGE2 in the pre...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90697-5

    authors: Saadi M,Gerozissis K,Dray F

    更新日期:1989-05-29 00:00:00

  • Activity of cat locus coeruleus noradrenergic neurons during the defense reaction.

    abstract::The single-unit activity of locus coeruleus noradrenergic (LC-NE) neurons was recorded in freely moving cats during naturally induced defense reactions. Defense reactions, consisting of arched back, piloerection, flattened ears and mydriasis, were elicited by exposing the cat either to a dog, or to a cat displaying ag...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90773-5

    authors: Levine ES,Litto WJ,Jacobs BL

    更新日期:1990-10-29 00:00:00

  • Differential expression of cellular prion protein in mouse brain as detected with multiple anti-PrP monoclonal antibodies.

    abstract::The normal cellular prion protein (PrP(C)) plays an essential role in the development of prion diseases. Indirect evidence has suggested that different PrP(C) glycoforms may be expressed in different brain regions and perform distinct functions. However, due to a lack of monoclonal antibodies (Mabs) that are specific ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02050-9

    authors: Liu T,Zwingman T,Li R,Pan T,Wong BS,Petersen RB,Gambetti P,Herrup K,Sy MS

    更新日期:2001-03-30 00:00:00

  • Quantitative morphological changes in the superior colliculus and the parabigeminal nucleus in the bilaterally microphthalmic rat.

    abstract::Quantitative morphological changes in the superior colliculus (SC) and the parabigeminal nucleus (PB) were studied in hereditary bilaterally microphthalmic rat, which lacks the optic nerve completely. Volumes of the retinorecipient superficial collicular layers of SC (SCS) to the central gray matter were decreased by ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(85)90012-4

    authors: Tokunaga A,Sugita S,Otani K,Terasawa K

    更新日期:1985-11-01 00:00:00

  • Relation of uptake and metabolism of (1,2,6,7-3H)testosterone to individual differences in sexual behavior in male guinea pigs.

    abstract::Male guinea pigs were given 3 tests for sexual behavior. Animals that never ejaculated were classified as low activity (LA), animals that ejaculated on one test were classified as medium activity (MA), and animals that ejaculated on two or more tests were classified as high activity (HA). Subsequently, animals from ea...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90929-x

    authors: Harding CF,Feder HH

    更新日期:1976-03-19 00:00:00

  • Characterization of tissue and functional deficits in a clinically translational pig model of acute ischemic stroke.

    abstract::The acute stroke phase is a critical time frame used to evaluate stroke severity, therapeutic options, and prognosis while also serving as a major tool for the development of diagnostics. To further understand stroke pathophysiology and to enhance the development of treatments, our group developed a translational pig ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146778

    authors: Kaiser EE,Waters ES,Fagan MM,Scheulin KM,Platt SR,Jeon JH,Fang X,Kinder HA,Shin SK,Duberstein KJ,Park HJ,West FD

    更新日期:2020-06-01 00:00:00

  • Nerve growth activities in rat peripheral nerve.

    abstract::Nerve growth activities in rat sciatic nerves were assayed by recording the neuritic outgrowth from chick embryonic ganglia cultured in collagen gels beside nerve fragments for two days. Living nerve explants released activity that resembled nerve growth factor (NGF) in its effect on sympathetic ganglia and that was a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90141-x

    authors: Richardson PM,Ebendal T

    更新日期:1982-08-19 00:00:00

  • Bleeping you out of the blink: sound saves vision from oblivion.

    abstract::The second of two targets (T2) presented in a rapid visual stream is often missed when presented shortly after the first (T1). This phenomenon has been referred to as the attentional blink. Here we show that the presentation of a synchronous sound enables T2 to escape the attentional blink, to the extent that performa...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.01.070

    authors: Olivers CN,Van der Burg E

    更新日期:2008-11-25 00:00:00

  • Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate.

    abstract::The aim of this investigation was to determine whether an ingredient of green tea, epigallocatechin gallate (EGCG) could attenuate oxidative stress-induced degeneration of the retina as occurs in age-related macular degeneration (AMD) and glaucoma. Initial in vitro studies on brain membranes showed that EGCG was appro...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.09.067

    authors: Zhang B,Osborne NN

    更新日期:2006-12-08 00:00:00

  • Microiontophoresis of baclofen on membrane potential and input resistance in bulbar respiratory neurons in the cat.

    abstract::Iontophoresis of baclofen produced hyperpolarization and a decrease in input resistance in 32 neurons and no effect in 24 neurons of the ventral respiratory group in cats. Iontophoresed phaclofen antagonized the effect of baclofen, but had negligible effects on periodic fluctuations in membrane potential and spike act...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90832-8

    authors: Haji A,Takeda R

    更新日期:1993-09-17 00:00:00

  • The fate of "dark" neurons produced by transient focal cerebral ischemia in a non-necrotic and non-excitotoxic environment: neurobiological aspects.

    abstract:BACKGROUND INFORMATION:We recently proposed novel neurobiological ideas for discussion regarding the common nature (malfunction of a physicochemical phenomenon genetically programmed for the morphological execution of ontogenetic apoptosis), mechanism of formation (phase transition in an intraneuronal gel structure) an...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.02.011

    authors: Kövesdi E,Pál J,Gallyas F

    更新日期:2007-05-25 00:00:00

  • pRb phosphorylation is regulated differentially by cyclin-dependent kinase (Cdk) 2 and Cdk4 in retinoic acid-induced neuronal differentiation of P19 cells.

    abstract::The retinoblastoma protein (pRb) is a key regulator of cell growth, differentiation and survival. pRb(-/-) mice show abnormal neuronal cell death in the developing brain. The function of pRb is regulated by its phosphorylation state. In this study, the phosphorylation of pRb during retinoic acid (RA)-induced neuronal ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01844-2

    authors: Watanabe Y,Watanabe T,Kitagawa M,Taya Y,Nakayama K,Motoyama N

    更新日期:1999-09-25 00:00:00

  • Physiological and morphological identification of a nonpyramidal hippocampal cell type.

    abstract::In intracellular recordings from the CA1 region of the hippocampal slice preparation, an infrequent cell type different from the predominant pyramidal cell has been characterized. The cells have very brief spikes, hyperpolarizing after-potentials, and tend to fire at a high spontaneous rate; unitary synaptic potential...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(78)90991-5

    authors: Schwartzkroin PA,Mathers LH

    更新日期:1978-11-17 00:00:00

  • Extranuclear estrogen receptor beta immunoreactivity is on doublecortin-containing cells in the adult and neonatal rat dentate gyrus.

    abstract::In adult female rats, estrogen receptor (ER) activation, particularly of ERbeta, promotes hippocampal neurogenesis. We previously reported that extranuclear ERbeta immunoreactivity (ir) in adult rats is on cellular profiles in or near the granule cell layer, which is the location of newly generated cells. During devel...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.08.084

    authors: Herrick SP,Waters EM,Drake CT,McEwen BS,Milner TA

    更新日期:2006-11-22 00:00:00

  • Phenytoin preferentially suppresses epileptiform activity in the superficial cortical layers of the cat.

    abstract::Clinically, phenytoin is thought to be useful in controlling seizure activity by preventing it's spread from the focus to neighboring tissue. Experimentally, it has been suggested that phenytoin's principal action is no longer polysynaptic pathways with primary foci affected less than surrounding tissue. In this study...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90994-6

    authors: Chatt AB,Ebersole JS

    更新日期:1984-03-19 00:00:00

  • The electrophysiological and morphological characteristics of feline dorsal root ganglion cells.

    abstract::The electrophysiological characteristics of physiologically typed L7 and S1 dorsal root ganglion (DRG) cells have been studied in the cat by intracellular recording. The injection of the fluorescent dye Lucifer Yellow has enabled us to study the morphology of these neurons. Our results show that over the entire range ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91391-0

    authors: Cameron AA,Leah JD,Snow PJ

    更新日期:1986-01-01 00:00:00

  • Pharmacological properties and monoaminergic mediation of the slow IPSP, in mammalian sympathetic ganglion.

    abstract::Phenoxybenzamine can selectively eliminate the s-IPSP, in the presence of anti-cholinesterases that enhance s-IPSP and s-EPSP; and the alpha 2-antagonist, yohimbine, can partially but consistently depress s-IPSP selectively. The results provide positive pharmacological support for the monoaminergic nature of the trans...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90321-3

    authors: Ashe JH,Libet B

    更新日期:1982-06-24 00:00:00

  • Nerve growth factor: a mitogenic signal for retinal Müller glial cells.

    abstract::Knowledge of the effects of nerve growth factor (NGF) on glia is limited. A CNS site where NGF-glial interactions may occur is the retina. NGF is endogenous to the retina, and the retinal Müller glial cells have NGF receptors. Here, we examined the possibility that NGF may be a mitogen for Müller glial cells, which of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91072-3

    authors: Ikeda T,Puro DG

    更新日期:1994-06-27 00:00:00

  • The effects of potassium on the rat middle cerebral artery.

    abstract::After traumatic brain injury, extracellular K(+) in brain can dramatically increase. We studied the effects of increased K(+) on the isolated pressurized rat middle cerebral artery (MCA). MCAs (200-250 microm OD) were isolated, cannulated with glass micropipettes, and pressurized. K(+) was increased in the extralumina...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02793-1

    authors: Golding EM,Steenberg ML,Johnson TD,Bryan RM Jr

    更新日期:2000-10-13 00:00:00

  • Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat.

    abstract::Zinc was measured in whole hippocampus and in hippocampal sub-regions by stable-isotope dilution mass spectrometry. In both man and the rat, the most zinc (102-145 ppm, dry weight) was found in the hilar region, the least (27-35) in the fimbria. The amount of zinc directly associated with mossy-fiber axons was estimat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90858-2

    authors: Frederickson CJ,Klitenick MA,Manton WI,Kirkpatrick JB

    更新日期:1983-08-29 00:00:00