Abstract：
:Gonadotropin-releasing hormone (GnRH) is a major neural signal for hypothalamic control of gonadotropin secretion which in turn influences gonadal steroid synthesis. Progesterone (P) is known to affect release and content of GnRH. The action mechanism of P on GnRH mRNA level remains, however, to be resolved. Here we report that P augments GnRH mRNA level in hypothalamic tissues derived from ovariectomized, estradiol-treated adult rats. The stimulatory action of P was time-dependent and lasted at least for 9 h. When RU486, a P receptor antagonist, was administered 1 hr before P treatment, it clearly blocked the stimulatory action of P on GnRH mRNA level. These results strongly suggest that P regulates GnRH gene expression in the rat hypothalamus, presumably through the P receptor-mediated mechanism.
journal_name
Brain Resjournal_title
Brain researchauthors
Cho BN,Seong JY,Cho H,Kim Kdoi
10.1016/0006-8993(94)90336-0subject
Has Abstractpub_date
1994-07-25 00:00:00pages
177-80issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(94)90336-0journal_volume
652pub_type
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