Abstract：
:The gustatory responses of the Mongolian gerbil were tested with 12 sugar alcohols. The electrophysiological effectiveness of the linear polyols as gustatory stimulants increased as the length of the carbon chain increased from 2 to 5. Six and 7 carbon acyclic polyols were no more effective than the pentitols. By comparison myoinositol, a cyclic polyol, was more effective in evoking a response. Responses to mixtures of D-sorbitol and sucrose suggest that these sugars compete for a common receptor site. A sucrose receptor site and a model of it is proposed.
journal_name
Brain Resjournal_title
Brain researchauthors
Jakinovich W Jr,Oakley Bdoi
10.1016/0006-8993(76)90861-1subject
Has Abstractpub_date
1976-07-16 00:00:00pages
505-13issue
3eissn
0006-8993issn
1872-6240pii
0006-8993(76)90861-1journal_volume
110pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The functional organization of projections from the cerebellar subcortical nuclei to the motor cortex through the nucleus ventralis lateralis (VL) of the thalamus was studied using tungsten microelectrodes for stimulation and recordings in acute and chronic cats. The following results were obtained. (1) Microstimulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90510-7
更新日期：1975-11-07 00:00:00
abstract：:Focal adhesion kinase (FAK) and proline-rich tyrosine kinase (PYK2) are two related non-receptor tyrosine kinases which are thought to play a role in transducing extracellular matrix (ECM)-derived survival signals into cells. The functions of FAK and PYK2 are linked to autophosphorylation of their specific tyrosine re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.022
更新日期：2015-05-05 00:00:00
abstract：:Fifty-three cell pairs in the somatosensory cerebral cortex were examined in pentobarbital-anesthetized cats for evidence of short latency interactions. Many neuronal pairs separated by distances of 150 to 500 micron were observed to have temporal dependencies. In a subset of 19 pairs where the surrounding multiunit a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91479-9
更新日期：1985-08-19 00:00:00
abstract：:The outer plexiform layer (OPL) of the retina has been studied in the developing cat, from E (embryonic day) 30. Prior to E51 the layer could not be detected, the retina comprising two cell layers, an inner layer which becomes the ganglion cell layer of the adult, and an outer 'neuroblast' layer. The OPL was first det...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90126-2
更新日期：1982-11-01 00:00:00
abstract：:Intracellular Neurobiotin-injections were used to label functionally identified neurons in the rostro-dorsomedial part of the trigeminal oral nucleus (Vo.r) in the cat. The labeled Vo.r neurons with the mechanoreceptive field in oral tissues innervated bilaterally either jaw-opening motoneurons or jaw-closing motoneur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.12.042
更新日期：2005-03-02 00:00:00
abstract：:Evidence exists that repeated injections of melatonin in rather large doses inhibit sexual performance in male rats. In contrast, systemic injection of small doses of this hormone stimulates sexual activity of normal male rats. In these experiments, systemic acute administration of melatonin in small doses (10-100 mic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02715-3
更新日期：2000-09-29 00:00:00
abstract：:MicroRNAs (miRNAs) are short, non-coding RNAs that negatively regulate target gene expression, and play an important role in cerebral ischemic injury. MiR-146a has been reported to be highly related to cell invasion, metastasis, immunity, inflammation and apoptosis. Previous studies have indicated that miR-146a can ei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.034
更新日期：2016-10-01 00:00:00
abstract：:We tested the hypothesis that a single systemic injection of 380 mg/kg of the muscarinic agonist pilocarpine would produce more diffuse and severe seizure-induced brain damage than a single injection of lithium (3 mEq/kg) followed 4 h later by < 1/10 the dosage of pilocarpine. The hypothesis was not supported; the pat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91126-6
更新日期：1994-06-20 00:00:00
abstract：:The preferential loss of GABAergic neurons in neocortex slab cultures after exposure to hypoxia was reinvestigated and confirmed using an improved morphometric analysis based on stereological principles. This preferential cell loss could be attenuated by treating the hypoxic slab cultures with the N-methyl-D-aspartate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91031-7
更新日期：1989-10-30 00:00:00
abstract：:The possible involvement of protein kinase A (PKA) in the muscarinic inhibition of the slow afterhyperpolarizing current (IAHP) was investigated in rat hippocampal pyramidal cells. IAHP was recorded using the whole cell method in hippocampal slices, and Rp-cAMPS, a PKA antagonist, was applied intracellularly. The inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90096-5
更新日期：1994-05-23 00:00:00
abstract：:Cerebral vascular density is correlated with metabolic demands, which increase in highly active brain areas. External inputs are an essential requirement in the modeling of the visual cortex. Experience-mediated development is very active during the first postnatal month, when congruous blood supply is needed. We stud...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02361-6
更新日期：2000-02-07 00:00:00
abstract：:Previous studies have demonstrated that punctate injections of 6-hydroxydopamine (6-OHDA) into structures along the ventral lamina terminalis reduce drinking responses elicited by angiotensin II (ANG II). The purpose of the present study was to extend these findings by quantifying the catecholamine depletions that are...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91567-9
更新日期：1989-02-20 00:00:00
abstract：:Pathophysiological responses to peripheral nerve injury include alterations in the activity, intrinsic membrane properties and excitability of spinal neurons. The intrinsic excitability of α-motoneurons is controlled in part by the expression, regulation, and distribution of membrane-bound ion channels. Ion channels, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.12.012
更新日期：2014-02-14 00:00:00
abstract：:Retinae taken from embryonic mice were transplanted to the brain of newborn rats. One eye was removed from the recipients at this time to promote innervation of host visual centers. After 4-6 weeks the optic nerve of the remaining eye was transected to eliminate all visual afferents of host origin and 4-6 days later t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91338-h
更新日期：1990-11-19 00:00:00
abstract：:Sleep spindles may be involved in synaptic plasticity. Learning-dependent increases in spindles have been observed in both humans and rats. In humans, the innate (i.e., baseline) number of spindles correlate with measures of academic potential such as Intelligence Quotient (IQ) tests. The present study investigated if...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.026
更新日期：2010-03-10 00:00:00
abstract：:Some occluded arteries of acute ischemic stroke (AIS) patients are not recanalized, even if thrombolytic therapy is performed. Considering such clinical settings, we examined the potential cerebroprotective efficacy of TAK-937, a novel cannabinoid receptor agonist, in young adult and aged rats with a permanent middle ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.06.014
更新日期：2013-08-14 00:00:00
abstract：:Recent studies have demonstrated the neuroprotective properties of the novel imidazoquinoline benzodiazepine receptor partial agonist, PNU-101017, in the gerbil forebrain ischemia model. The compound effectively reduces delayed post-ischemic (5 min bilateral carotid occlusion) hippocampal CA1 neuronal degeneration eve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00478-8
更新日期：1998-07-06 00:00:00
abstract：:In the rat, calbindin-like immunoreactivity was observed at both the light and electron microscopic levels within the chemoreceptor neurons of the vomeronasal organ (VNO) and both intragemmal cells and associated nerve fibers of the circumvallate taste buds. All VNO neurons were immunoreactive. Only a subset of intrag...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90493-s
更新日期：1992-02-14 00:00:00
abstract：:We used amygdala-kindled seizures in rats to study the function of striatal gamma-aminobutyrate (GABA) in the regulation of the seizure threshold of the limbic forebrain. Microinjections of the GABAA antagonist, bicuculline methiodide, 1 pmol, into the caudate-putamen protected rats against amygdala-kindled seizures. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91089-4
更新日期：1987-05-19 00:00:00
abstract：:Radioautography was used to study the intraneuronal distribution of [3H]-serotonin (5-HT) and/or its derivatives selectively taken up by the olfactory bulb (OB) serotonergic terminals and subsequently transported to their parent cell bodies in the midbrain raphe nuclei. This was done 24 h after injection of [3H]5-HT i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90405-9
更新日期：1980-09-08 00:00:00
abstract：:The amygdala plays an important role in the regulation of motivational states, especially those associated with addiction. The amygdala also expresses high levels of brain-derived neurotrophic factor (BDNF), an activity-dependent neurotrophin that can influence the reinforcing and locomotor activating properties of ps...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03160-8
更新日期：2002-09-13 00:00:00
abstract：:Recently, a novel method for detection of DNA synthesis has been developed based on the incorporation of 5-ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, into cellular DNA and the subsequent reaction of EdU with a fluorescent azide in a copper-catalyzed [3+2] cycloaddition ("Click" reaction). In the present stud...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.092
更新日期：2010-03-10 00:00:00
abstract：:In the course of studies on the responsiveness of mediobasal hypothalamic neurons to the iontophoretic application of cortisol, it was found that positive currents applied to a sodium chloride (1 M) barrel alone, but not to a choline chloride (1 M) barrel, frequently increased the firing of these neurons. Subsequently...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91091-0
更新日期：1983-08-22 00:00:00
abstract：:The default mode network (DMN) is characterised by coherent very low frequency (VLF) neural oscillations in the resting brain. The attenuation of this activity has been demonstrated following the transition from rest to performance of a broad range of cognitive goal-directed tasks. Whether the activity of resting stat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.05.043
更新日期：2013-08-02 00:00:00
abstract：:Dendritic architecture and distribution of dendritic protrusions were studied on Golgi-impregnated neurons in the medial preoptic area (MPOA) of infant rats (7 and 20 days old), of animals at puberty (34 days old) and of postpubertal rats (90 days old) using computerized image analysis. The protrusions showed a peak d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90006-4
更新日期：1986-04-01 00:00:00
abstract：:The effects of a wide range of doses of systemically administered cysteamine were studied on locomotor behavior, passive avoidance memory, cortical and cerebrospinal fluid somatostatin-like immunoactivity and cortical levels of dopamine and norepinephrine. High doses of cysteamine (200 and 250 mg/kg s.c.) led to susta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90060-6
更新日期：1987-02-17 00:00:00
abstract：:To examine the role played by the basal forebrain cholinergic system in cortical activation, neuronal activity was investigated in the globus pallidus and substantia innominata of urethane-anaesthetized rats during large cortical slow waves and spontaneous or elicited low voltage fast activity. An effort was made to i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91521-6
更新日期：1987-12-22 00:00:00
abstract：:Ventilation is peripherally controlled by afferent activity arising from the peripheral chemoreceptors. In the rat, chemosensory activity is conveyed to the central nervous system through axons of neurons located in the nodose-petrosal-jugular-complex. These neurons have distinct electrophysiological properties, inclu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.08.027
更新日期：2016-10-15 00:00:00
abstract：:Amphetamine releases dopamine through a transporter-mediated mechanism. The purpose of this report was to further our understanding of the intracellular pool from which amphetamine releases dopamine: the cytoplasmic pool, the vesicular pool, or both. Rats were treated with D-amphetamine (AMPH) (1.0 or 10.0 mg/kg) or a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00720-3
更新日期：1998-09-21 00:00:00
abstract：:Recent studies have demonstrated that gonadectomy of adult male rats induces dendritic growth of neuroendocrine neurons in the arcuate nucleus. We have hypothesized that these changes are secondary to the loss of testosterone negative feedback. In the present study, we examined the effects of testosterone replacement ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03083-3
更新日期：2001-01-26 00:00:00
