Abstract：
:To elucidate the role of the large conductance calcium-activated potassium channel (BK(Ca) channel) in the production of bursting activity, which is characteristic of convulsions, effects of iberiotoxin (IbTX), a selective blocker of the BK(Ca) channel, on bursting activity, induced by various procedures were examined using primary cultured neurons from the cerebral cortex of mice. IbTX completely inhibited bursting activity induced by pentylenetetrazol (PTZ), caffeine, 1,4,5-inositol triphosphate (IP3) and direct forced increase of intracellular calcium. Inherent spontaneous bursting activity in the cerebral cortical neurons of the El mouse, which shows a high susceptibility to convulsions was also completely inhibited by IbTX. Apamin, a specific blocker of the small conductance calcium-activated potassium channel (SK(Ca) channel) showed no inhibition of bursting activity. These findings suggest that the BK(Ca) channel is essential for the production of bursting activity, and also suggest the possibility of clinical use of blocking agents of the BK(Ca) channel against intractable epilepsy.
journal_name
Brain Resjournal_title
Brain researchauthors
Jin W,Sugaya A,Tsuda T,Ohguchi H,Sugaya Edoi
10.1016/s0006-8993(00)01943-0subject
Has Abstractpub_date
2000-03-31 00:00:00pages
21-8issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)01943-0journal_volume
860pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The effects of streptozotocin-induced diabetes mellitus on the activity of discrete regions of the brain were studied with histochemical localization and photodensitometric quantification of the metabolic enzyme, hexokinase. Two weeks after a single injection of streptozotocin (65 mg/kg, i.p.), plasma glucose and osmo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91593-6
更新日期：1990-07-02 00:00:00
abstract：:The intermediate, medial part of the hyperstriatum ventrale (IMHV) is an area of the avian forebrain which is essential for two forms of early learning in the domestic chick. We have developed an in vitro slice preparation which contains part of the IMHV and have found that the electrophysiological properties of the a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00361-7
更新日期：1996-07-15 00:00:00
abstract：:Depolarization by K+ (50 mM) of cultured chick retina cells released 1.14 +/- 0.28% of the accumulated [3H] gamma-aminobutyric acid (GABA) in the absence of Ca2+, but when 1.0 mM Ca2+ was present, the internal free calcium ion concentration [Ca2+]i rose by about 750 nM and the [3H]GABA release about doubled to a value...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90974-e
更新日期：1992-09-18 00:00:00
abstract：:We have shown that, when an amyloid-beta peptide (Abeta) overproducing transgenic mouse model (PSAPP) of Alzheimer's disease (AD) is treated with a depleting antibody against CD40L, it causes marked attenuation of Abeta pathology associated with decreased amyloidogenic processing of amyloid precursor protein (APP) and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.05.004
更新日期：2004-07-23 00:00:00
abstract：:The double-labeling, fluorescent dye technique was used in order to demonstrate the extent to which the central processes of renal afferent neurons directly project to the brainstem. One injection of a fluorescent dye was placed in the cortex of the left kidney of male rats, and a second injection of a different dye w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91154-5
更新日期：1984-04-23 00:00:00
abstract：:Determining the mechanism by which fluorescent retrograde neuronal tracers are taken up requires knowledge of their composition. It has been claimed that Fluoro-Gold, a retrogradely transported fluorescent neuronal tracer, is 2-hydroxy-4,4'-diamidinostilbene (hydroxystilbamidine), an amidine antibiotic. However, this ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90241-m
更新日期：1991-07-05 00:00:00
abstract：:The possibility has been mentioned that a change in the structure is responsible for the deviant behavioral activity of gamma-endorphin in extracts of postmortem brain and pituitary gland samples of schizophrenic patients. This paper describes the investigation of this possibility by means of: amino acid composition a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90896-6
更新日期：1986-06-18 00:00:00
abstract：:The effects of lateral hypothalamic (LH) lesions were studied in golden-mantled ground squirrels, Spermophilus lateralis, a species of mammalian hibernator that displays endogenous circannual body weight cycles when kept in constant conditions. The lesions were made during the weight-gain phase. Evidence that the lesi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91518-0
更新日期：1986-12-10 00:00:00
abstract：:Effects of iontophoretically applied dopamine were investigated in prefrontal neurons of the monkey which showed activity changes during a visual reaction time task. The task consisted of an initial waiting phase (3.0 s), a warning phase (green lamp, 1.5-3.5 s), a lever-release GO phase (red lamp) and a reward phase. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90385-9
更新日期：1986-04-23 00:00:00
abstract：:Local circuit neurons in the human anterior thalamus (AT) were identified on the basis of glutamic acid decarboxylase immunoreactivity (GAD-IR). GAD-IR neurons of the AT displayed small diameter somas with thin, sparsely-branching dendrites, consistent with the morphological characteristics of local circuit neurons fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03194-8
更新日期：2001-12-27 00:00:00
abstract：:Recent evidence suggests that cocaine addiction may involve progressive drug-induced neuroplasticity of the dorsal striatum. Here, we examined the effects of a) dorsolateral caudate putamen (dlCPu) lesions on cocaine self-administration, extinction of responding, and subsequent reinstatement to cocaine-seeking, and b)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.08.030
更新日期：2011-10-12 00:00:00
abstract：:Cellular distribution of the two forms of SERCA2 was examined in adult chicken brain. Four regions of the brain were analyzed with three immunological reagents: a monoclonal antibody that recognizes both forms of SERCA2, and two antisera which are specific for the two alternative forms, SERCA2b or SERCA2a. Cerebellar ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91357-x
更新日期：1993-03-05 00:00:00
abstract：:Error processing during motor control involves the evaluation of "high-level" errors (i.e., failures to meet a system goal) by a frontal system involving anterior cingulate cortex and the evaluation of "low-level" errors (i.e., discrepancies between actual and desired motor commands) by a posterior system involving po...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.024
更新日期：2007-06-25 00:00:00
abstract：:The present study examined whether substance P (Sub P) could protect against quinolinic acid (QA)-induced lesions of the striatum, as measured by a loss of striatal D1 dopamine receptors. Sub P was extruded into Evac polymer rods for slow release. One 4 mm rod segment was implanted unilaterally into the striatum of ea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90974-r
更新日期：1993-11-19 00:00:00
abstract：:Neural correlates of conscious awareness can be comfortably studied when awareness of the target stimuli is a varying dependent variable in the experimental conditions where the key independent variables are kept invariant. We presented vernier targets backward masked by an invariant grating with invariant SOA. EEG da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.085
更新日期：2009-05-19 00:00:00
abstract：:Abecarnil is a recently described beta-carboline which acts at central benzodiazepine receptors (BZR) and has anxioselective/anticonvulsant properties. While it may be classified provisionally as a partial agonist at BZR, there is also evidence that its pharmacological profile may be due to a selective action at BZR s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90862-4
更新日期：1992-12-18 00:00:00
abstract：:The potential evoked in the pyriform cortex by single-pulse stimulation of the olfactory bulb was examined before and after single and repeated elicitation of an epileptiform afterdischarge produced by stimulation of the olfactory bulb. A single afterdischarge (AD) produced a rapid (i.e. within 5 min) increase in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91275-2
更新日期：1985-12-30 00:00:00
abstract：:Phenylethanolamine N-methyltransferase (PNMT) activity was measured in adrenal glands and medulla oblongata from 4 inbred rat strains, Fischer 344, Buffalo, Lewis and Sprague-Dawley rats. Adrenal enzyme activity was markedly different among the strains with the highest in Fischer, followed by Sprague-Dawley, Lewis and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91476-9
更新日期：1986-04-30 00:00:00
abstract：:The importance of particular genes in neuronal death following global cerebral ischemia can readily be studied in genetically modified mice provided a reliable model of ischemia is available. For that purpose, we developed a mouse model of global cerebral ischemia that induces consistent damage to different regions of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03014-2
更新日期：2003-08-29 00:00:00
abstract：:In our previous study, we have found that leucine-rich repeats and immunoglobulin-like domains 1(LRIG1) can improve the chemosensitivity in U251 cells whereas the role of LRIG1 in multidrug resistance (MDR) remains unknown. Here, we reported that LRIG1 can reverse MDR by inhibiting epidermal growth factor (EGF) recept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.03.023
更新日期：2015-06-22 00:00:00
abstract：:The purpose of this study was to examine mechanisms involved in the coupling of neuronal activity to cerebral blood flow (CBF). CBF was measured in rat cerebellum using laser-Doppler flowmetry during stimulus-evoked neuronal activity and related to the distribution of the extracellular field potential. Local electrica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01354-7
更新日期：1996-02-26 00:00:00
abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy CADASIL is caused by more than a hundred NOTCH3 mutations. Virtually all encoded mutant proteins contain an odd number of cysteines. As such, structural changes in NOTCH3 may be the primary molecular abnormality in CADASIL. Thus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.08.018
更新日期：2014-10-02 00:00:00
abstract：:The GABA agonist muscimol, injected into the depressor area of the caudal ventrolateral medulla, increased blood pressure and increased the expression of the immediate early gene c-fos in the rostral ventral medulla (RVM) of the rat. The number of Fos-immunoreactive (Fos-IR) neurons seen in the RVM was increased 3-fol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90056-6
更新日期：1994-05-16 00:00:00
abstract：:We tested the hypothesis that intravenous infusion of human marrow stromal cells (hMSC) with a nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl) aminio] diazen-1-ium-1,2-diolate (DETA/NONOate), enhances angiogenesis, neurogenesis and neurological functional recovery after stroke in rats compared to indivi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.080
更新日期：2004-04-16 00:00:00
abstract：:Few clinical or experimental studies have carried out systematic investigations of cutaneous and deep sensibility in areas with referred muscle pain. Therefore, no clear signs of increased or decreased psychophysical responses to various somatosensory stimuli are found in referred pain areas. In the present study, a t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01077-3
更新日期：1997-01-02 00:00:00
abstract：:The present study examines the effects of ibotenic acid lesions of the medial amygdala, the bed nucleus of the stria terminalis and the medial preoptic area on the display of paced mating behavior in female rats. Lesions of either the medial amygdala or the bed nucleus of the stria terminalis have no effect on the dis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.10.056
更新日期：2004-02-27 00:00:00
abstract：:Immunohistochemical localization of brain-derived neurotrophic factor (BDNF) in the monkey brain was investigated using a polyclonal anti-BDNF antibody produced in our laboratory. The antibody recognized a single band in monkey brain homogenates, and the estimated molecular weight was approximately 14 kDa, which corre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01082-3
更新日期：1999-03-13 00:00:00
abstract：:Thyroid hormones are critical for the maturation and function of the central nervous system. Insufficiency of thyroid hormones in the adulthood causes a wide range of cognitive dysfunctions, including deficits in learning and memory. The present study investigated whether adult-onset hypothyroidism would alter synapti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.042
更新日期：2006-06-22 00:00:00
abstract：:Our recent study has shown that many afferent fibers in the ventral root are third branches of dorsal root ganglion cells in addition to their processes in the peripheral nerve and the dorsal root. From results of this study, we hypothesized that most of the afferent fibers in the normal ventral root are extra process...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91030-5
更新日期：1989-10-30 00:00:00
abstract：:Bilateral intranigral administration of the selective NK-1 tachykinin receptor agonist [AcArg6, Sar9, Met(O2)11]SP6-11 (0-1 nmol total bilateral dose) selectively induced grooming in rats. This response was blocked by concurrent intranigral administration of the NK-1 tachykinin receptor antagonist RP 67580 (2 nmol), b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00940-r
更新日期：1995-11-27 00:00:00
