Abstract：
:The present study examined whether substance P (Sub P) could protect against quinolinic acid (QA)-induced lesions of the striatum, as measured by a loss of striatal D1 dopamine receptors. Sub P was extruded into Evac polymer rods for slow release. One 4 mm rod segment was implanted unilaterally into the striatum of each rat. One week later, animals received a striatal injection of QA (50, 75 or 100 nmol/microliters) medial to the implanted rod. Controls received QA alone. Three weeks later, there was a dose-dependent loss of D1 receptors following QA. Sub P rods protected the striatum from QA-induced D1 receptor loss at this time. These results support the neuroprotection role of Sub P on excitotoxicity.
journal_name
Brain Resjournal_title
Brain researchauthors
Sanberg PR,Emerich DF,Aebischer P,Amisetti SM,Ouellette W,Koutouzis TK,Cahill DW,Norman ABdoi
10.1016/0006-8993(93)90974-rsubject
Has Abstractpub_date
1993-11-19 00:00:00pages
327-9issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)90974-Rjournal_volume
628pub_type
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