Evidence for phosphatidylinositol anchorage of opioid binding proteins in rat brain.

Abstract:

:Treatment of rat brain sections and of thalamic and striatal membranes with phosphatidylinositol phospholipase C (PIPLC), an enzyme known to hydrolyse only phosphatidylinositol and its derivatives, significantly alters the specific binding of mu- and delta-opioid ligands on their receptors. These results suggest that some opioid binding proteins are membrane-anchored by a glycosylphosphatidylinositol (GPI) linkage.

journal_name

Brain Res

journal_title

Brain research

authors

Trovero F,Glowinski J,Lévy M

doi

10.1016/0006-8993(90)90391-n

subject

Has Abstract

pub_date

1990-12-24 00:00:00

pages

381-5

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(90)90391-N

journal_volume

537

pub_type

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