Abstract：
:The tumor promoting compound 12-O-tetradecanoyl-phorbol-13-acetate (TPA) specifically binds to and activates protein kinase C (PKC). This enzyme is widely distributed in the brain. It plays a pivotal role in transmembrane signalling. Arachidonic acid conversion is a common cellular response to membrane perturbation. We report that TPA evokes synthesis and release of the cyclo-oxygenation product prostaglandin E by cultured rat astrocytes. The inert stereo-isomer 4 alpha-phorbol 12,13-didecanoate, was devoid of stimulatory activity. We conclude that activation of PKC is a crucial step in the initiation of the arachidonic acid cascade in astrocytes. It is suggested that production of proinflammatory and immunomodulating mediators derived from arachidonate by astrocytes may be relevant in the context of normal and aberrant immune responses within the central nervous system.
journal_name
Brain Resjournal_title
Brain researchauthors
Hartung HP,Toyka KVdoi
10.1016/0006-8993(87)90461-6subject
Has Abstractpub_date
1987-08-11 00:00:00pages
347-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90461-6journal_volume
417pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In alert cats, extracellular spikes of neurons in the medial pontine tegmentum were recorded simultaneously with whole nerve discharges of the abducens and medial rectus nerves during horizontal vestibular nystagmus. Nystagmus-related neurons were classified by their firing patterns in relation to the abrupt cessation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90941-0
更新日期：1981-10-05 00:00:00
abstract：:Both amphetamine and cocaine lead to an intake pattern in chronic addicts in which the drug is taken repeatedly over prolonged periods. While continuously administered amphetamines, designed to mimic this intake pattern, have a neurotoxic effect on caudate dopamine terminals, several studies have failed to find simila...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90207-p
更新日期：1992-12-11 00:00:00
abstract：:In the present functional magnetic resonance imaging (fMRI) study, we aimed to evaluate whether distinct regions of the hippocampus were associated with spatial memory for items presented in different locations of the visual field. In Experiment 1, during the study phase, participants viewed abstract shapes in the lef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.02.029
更新日期：2018-05-15 00:00:00
abstract：:Manual gestures occur on a continuum from co-speech gesticulations to conventionalized emblems to language signs. Our goal in the present study was to understand the neural bases of the processing of gestures along such a continuum. We studied four types of gestures, varying along linguistic and semantic dimensions: l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.04.034
更新日期：2009-06-18 00:00:00
abstract：:Kindling of the amygdaloid complex in rats results in an enhanced emotionality frequently expressed by an elevated anxiety and defensive attitude toward other animals. Defensive attitude may have important consequences in social context and if tested in a large space it may eventually lead to social withdrawal. To tes...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03162-6
更新日期：2001-12-13 00:00:00
abstract：:Neurotensin (NT) is an endogenous peptide which has been hypothesized to function in the central nervous systems as a neurotransmitter. Injection of NT into the cerebral ventricular system of rodents produces antinociception in a variety of analgesia tests. In the hot plate test, direct microinjection of NT into the c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90251-7
更新日期：1982-07-15 00:00:00
abstract：:Prolonged seizures have long been known to be associated with cell injury and cell death in brain. Such seizure-related neuronal injury has been assumed to be mediated by glutamate, the same excitatory amino acid in the central nervous system which propagates the seizure itself. Elevated extracellular concentrations o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00658-0
更新日期：1996-10-21 00:00:00
abstract：:Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. Previous MRI studies have revealed that POAG can be associated with alterations in hippocampal function. Thus, the aim of this study was to investigate a relationship between chronic high intraocular pressure (IOP) and hippocamp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.09.001
更新日期：2017-11-15 00:00:00
abstract：:The localization of the methionine-enkephalin-Arg6-Gly7-Leu8 (Met-Enk-Arg-Gly-Leu)-like immunoreactivity-containing neurons in the rat lumbosacral spinal cord was immunohistochemically examined by an antiserum very specific to Met-Enk-Arg-Gly-Leu. The immunoreactive neurons occupied the positions corresponding to the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90804-3
更新日期：1987-03-17 00:00:00
abstract：:38 primary afferents originating from de-efferented cat tibialis anterior muscle spindles were investigated. Ramp-and-hold stretches of the host muscle were performed with a varying amount of muscle pre-stretch while recording the primary afferent discharges. From the discharge responses an interspike interval functio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91650-h
更新日期：1993-05-28 00:00:00
abstract：:Horseradish peroxidase injections into the medulla of tadpoles demonstrate, by back-filling, efferent neurons in the torus semicircularis which project to the ipsilateral superior olive. This projection, as well as one to the vicinity of the efferent neurons of the contralateral VIII and lateral line nerves, is confir...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90774-1
更新日期：1984-02-06 00:00:00
abstract：:The effects of divalent and trivalent cations on the gamma-aminobutyric acid (GABA)-induced chloride current were studied with rat dorsal root ganglion neurons in primary culture using the whole-cell configuration of the patch-clamp technique. Lanthanum (La3+) reversibly potentiated the GABA-induced current with a hal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91510-y
更新日期：1993-04-02 00:00:00
abstract：:Pouch young opossums aged from 5 to 34 days underwent unilateral eye enucleation and the projection from the remaining eye to the superior colliculus (SC) was explored at maturity by anatomical and physiological methods. The results were compared to data from normal or adult enucleated animals. Analysis of the experim...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90236-1
更新日期：1986-06-01 00:00:00
abstract：:Binding sites of atrial natriuretic peptide in the cerebral microvessels and choroid plexus of spontaneously hypertensive rats (SHR) and Wistar Kyoto control rats (WKY) were measured. In the microvessels, the number of ANP binding sites was lower in SHR than WKY, but there was no difference in affinity of binding site...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90984-j
更新日期：1990-06-04 00:00:00
abstract：:Diabetes mellitus can lead to functional and structural deficits in both the peripheral and central nervous system. The pathogenesis of these deficits is multifactorial, probably involving, among others, microvascular dysfunction and alterations in intracellular calcium homeostasis. The present study examined the effe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.12.025
更新日期：2005-02-21 00:00:00
abstract：:The sublaminar binding profiles of (D-Ala-NMe-Phe-Gly-ol)-enkephalin (DAGO), (2-D-penicillamine), 5-D-penicillamine)-enkephalin (DPDPE), and dynorphin A(1-8) (DYN) were studied in the CA1 subfield and dentate gyrus of rat hippocampal formation. Binding was assayed on cryomicrotome sections using coverslip autoradiogra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91215-2
更新日期：1988-09-13 00:00:00
abstract：:(1) Changes during development in the levels of proteinases and peptidases were measured in brain homogenates. At all ages di- and tripeptidase levels were 7-15-fold higher than proteinase activity. (2) Cathepsin A and D and neutral proteinase activity first decreased (during the 5 days before birth) and then increase...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90705-2
更新日期：1975-03-21 00:00:00
abstract：:The effects of pentylenetetrazol (PTZ) following induction of long-term potentiation (LTP) on population spikes in CA1 of hippocampal slices were investigated. Population spikes were evoked by activation of Schaffer collaterals with a range of stimulation intensities. LTP was induced using θ-pattern primed burst...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02672-x
更新日期：2000-09-22 00:00:00
abstract：:The effects of pituitary adenylate cyclase activating polypeptides (PACAPs: PACAP27, PACAP38) on glutamate-induced neurotoxicity were examined using cultured retinal neurons obtained from 3- to 5-day old Wistar rats. Cell viability was evaluated by double staining with fluorescein diacetate and propidium iodide. Effec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01690-x
更新日期：1999-08-21 00:00:00
abstract：:The present study using near-infrared spectroscopy (NIRS) examined prefrontal activation associated with maze-solving performance in adult humans. The participants were required to solve a plus-shaped maze, comparable to the one used for pigeons and human children to behaviorally assess planning processes, by moving a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.047
更新日期：2011-02-16 00:00:00
abstract：:Evidence is provided that carbonic anhydrase-II is localized in the central nervous system to wide spread systems of oligodendrocytes and restricted astroglia populations, involving both fiber bundles and neuropil. It is suggested that CO2 formed in activated axons may, via carbonic anhydrase-II, give rise to protons ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00026-m
更新日期：1995-04-03 00:00:00
abstract：:Extracellular single unit recordings were made from various depths in the left olfactory bulb of ten anaesthetised, freely breathing adult hens (Gallus domesticus) using glass insulated tungsten microelectrodes. The 66 spontaneously active neurons recorded had widely variable firing rates (mean 4.9 spikes/s, range 0.1...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03376-5
更新日期：2002-03-01 00:00:00
abstract：:The medial amygdala plays a key role in regulating adult social behavior and undergoes structural changes during puberty that may be driven by gonadal hormone secretion during this developmental period. The current study sought to investigate potential organizational effects of testosterone during puberty, activationa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.035
更新日期：2012-06-15 00:00:00
abstract：:The overall volume of the three main inferior olivary (ION) subnuclei increases four-fold between the day of birth (PO) and P21. The rate of this increase is uneven; between P10 and P15 there is an abrupt acceleration which parallels the period of intense synaptogenesis and maturation of the neuropil. The growth of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90029-4
更新日期：1984-11-01 00:00:00
abstract：:Physical exercise can induce brain plasticity and reduce the cognitive decline observed in type 1 diabetes mellitus (T1DM). We investigated the effects of physical exercise to prevent or reverse spatial memory deficits produced by diabetes and some biochemical and immunohistochemical changes in hippocampal astrocytes ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.10.024
更新日期：2017-01-15 00:00:00
abstract：:The effects of unilateral intrahippocampal injections of the non-competitive NMDA receptor antagonist, MK-801, on local cerebral glucose utilisation have been examined in conscious rats using [14C]2-deoxyglucose autoradiography. The intrahippocampal injection of MK-801 (10 nmol) induced significant marked increases in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90995-n
更新日期：1990-06-04 00:00:00
abstract：:Morphine is one of the most potent analgesics used in medicine and it's long-term use is associated with the risk of the state of dependence. The cessation of chronic morphine administration leads to withdrawal signs which are associated with neurotransmitter dysregulations within mesolimbic system. Adenosine 5'-triph...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.05.025
更新日期：2019-09-15 00:00:00
abstract：:Odor stimulation of the nose in the box turtle and the gopher tortoise produced a characteristic series of slow potentials in the olfactory bulb which were referred to as the odor evoked response. When recorded with direct coupling, the odor evoked response had 3 components: wave I, a short duration monophasic event; ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90914-2
更新日期：1975-10-24 00:00:00
abstract：:The analysis of the dynamic properties of epileptiform activity in vitro has led to a better understanding of the time course of neural synchronization and seizure states. Nonlinear analysis is thus potentially useful for the prediction of seizure onset. We have used nonlinear analysis methods to investigate the devel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03166-8
更新日期：2001-02-02 00:00:00
abstract：:Microinjection of mRNA from adult rat brains into Xenopus oocytes induced an electrophysiological response to acetylcholine in the cells. The cells responded to acetylcholine through muscarinic receptors which appeared on the cell surface after microinjection of the mRNA and showed the depolarization, mainly due to an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90166-0
更新日期：1985-07-15 00:00:00
