Abstract：
:Glial cell line-derived neurotrophic factor (GDNF) activates protein kinase Akt/PKB by phosphorylation (p-Akt) which plays key roles in cell survival. In the current study, we investigated a temporal expression of p-Akt by immunohistochemical analysis after a topical application of GDNF to normal cerebral hemisphere of rats. Although p-Akt immunoreactivity was weakly present in the sham control neural cells, GDNF application greatly enhanced it at 3 h, which lasted until 1 day. These results indicate that p-Akt is expressed in neuronal cells under physiological conditions, and that topical application of GDNF greatly enhanced the phosphorylation of Akt in normal rat brain.
journal_name
Brain Resjournal_title
Brain researchauthors
Jin G,Omori N,Li F,Sato K,Nagano I,Manabe Y,Shoji M,Abe Kdoi
10.1016/s0006-8993(02)03521-7subject
Has Abstractpub_date
2002-12-27 00:00:00pages
429-33issue
2eissn
0006-8993issn
1872-6240pii
S0006899302035217journal_volume
958pub_type
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