Hippocampal neurotrophic factor: characterization and response to denervation.

abstract：:Striatal glial cell line-derived neurotrophic factor (GDNF) mRNA levels in both young (2-month old) and old (11-month old) C57BL/6J mice were quantified at 3, 7 and 21 days following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. MPTP did not alter the expression of GDNF mRNA in these animals. Immunore...

journal_title：Brain research

authors： Inoue T,Tsui J,Wong N,Wong SY,Suzuki F,Kwok YN

更新日期：1999-05-01 00:00:00

abstract：:gamma-L-Glutamyl-L-aspartic acid (gamma-LGLA) has been isolated from Datura stramonium; its structure has been determined and it was then synthesized. In male Swiss mice intraperitoneal administration of the natural peptide (125 nmol/kg) or of the synthetic peptide (25-2500 nmol/kg) 24 h after acquisition of a Y-maze ...

journal_title：Brain research

authors： Ungerer A,Schmitz-Bourgeois M,Mélan C,Boulanger Y,Reinbolt J,Amiri I,de Barry J

更新日期：1988-04-19 00:00:00

abstract：:Distribution and time course of the occurrence of "dark" neurons were compared with the EEG activity and behavior of rats during 4-aminopyridine (4-AP) induced epileptic seizures. A crystal of the K(+) channel blocker 4-AP (0.5 mg/kg) was placed onto the exposed parieto-occipital cortex of Halothane-anesthetized rats ...

journal_title：Brain research

authors： Baracskay P,Szepesi Z,Orbán G,Juhász G,Czurkó A

更新日期：2008-09-04 00:00:00

abstract：:The neuroactive steroid 5 beta-pregnan-3 alpha-ol-20-one (5 beta 3 alpha) modulates GABAA receptor function by potentiating postsynaptic GABA currents. While much is now known about the postsynaptic action of neurosteroids, far less is known about how they affect neurotransmission. We have investigated the synaptic ac...

journal_title：Brain research

authors： Reith CA,Sillar KT

更新日期：1997-10-03 00:00:00

abstract：:A simple pressure injection technique was developed to deliver substances into specific regions of the embryonic and neonatal mouse brain in vivo. The retrograde tracers Fluorogold and cholera toxin B subunit were used to test the validity of the technique. Injected animals survived the duration of transport (24-48 h)...

journal_title：Brain research

authors： Davidson S,Truong H,Nakagawa Y,Giesler GJ Jr

更新日期：2010-01-11 00:00:00

abstract：:Superior colliculus cells that respond to a given sensory input (visual or auditory) were influenced by the presence of a stimulus in the other modality. This is a form of sensory-sensory integration which has previously been thought to be involved in initiating the orientation of receptor organs in response to such c...

journal_title：Brain research

authors： Peck CK

更新日期：1987-09-08 00:00:00

abstract：:Freezing and escape responses induced by gradual increases in the intensity of the electrical current applied to dorsal regions of the periaqueductal gray (dPAG) cause a distinct pattern of Fos distribution in the brain. From these studies, it has been suggested that a pathway involving the dPAG itself, dorsomedial hy...

journal_title：Brain research

authors： Ferreira-Netto C,Borelli KG,Brandão ML

更新日期：2005-01-21 00:00:00

abstract：:The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adeno...

journal_title：Brain research

authors： Janusz CA,Berman RF

更新日期：1993-08-13 00:00:00

abstract：:Cyclic nucleotide phosphodiesterase-4 (PDE4) is a component of signaling pathways involved in the mediation of antidepressant activity. Of the four PDE4 subtypes, PDE4D appears to be of particular importance, given the finding that PDE4D-deficient mice exhibit an antidepressant-like behavioral phenotype. In mouse hipp...

journal_title：Brain research

authors： Dlaboga D,Hajjhussein H,O'Donnell JM

更新日期：2006-06-22 00:00:00

abstract：:Stressors produce rapid activation of the hypothalamic-pituitary-adrenal axis, which typically resolves within 60-90 min following termination of the stressor. In addition, some stressors such as inescapable tailshock (IS) also produce elevated basal levels of corticosterone (CORT), and reduced serum levels of cortico...

journal_title：Brain research

authors： Deak T,Nguyen KT,Cotter CS,Fleshner M,Watkins LR,Maier SF,Spencer RL

更新日期：1999-11-20 00:00:00

abstract：:The mRNA level of the 17-kDa protein neurogranin (NG), a postsynaptic substrate of the protein kinase C, has previously been found to be decreased in rat forebrain after 24-h sleep deprivation (SD). To investigate the functional significance of this finding in various forebrain regions, the effect of 24-h SD on the mR...

journal_title：Brain research

authors： Neuner-Jehle M,Rhyner TA,Borbély AA

更新日期：1995-07-10 00:00:00

abstract：:Previous work had indicated that animals that were sleep-deprived and then trained on a passive avoidance task show poor retention of the task 24 h later after being allowed to sleep freely again. Cholinergic involvement is suggested by the fact that this effect is prevented by treatment with the muscarinic agonist pi...

journal_title：Brain research

authors： Moreira KM,Hipólide DC,Nobrega JN,Bueno OF,Tufik S,Oliveira MG

更新日期：2003-07-04 00:00:00

abstract：:The effect of the non-phenothiazine calmodulin-inhibitor R 24571 on transmitter release at the frog neuromuscular junction has been investigated. MEPP frequency was reduced by 25-40% at low concentrations of the drug (2-5 X 10(-7) M) but increased at higher concentrations. These effects were independent of [Ca2+]o. EP...

journal_title：Brain research

authors： Sahaf ZY,Publicover SJ

更新日期：1985-11-25 00:00:00

abstract：:Blockade of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors with 6-nitro-7-sulfamoyl-benzo-[f]quinoxaline-2,3(1H,4H)-dione (NBQX) activates tuberoinfundibular (TIDA) and periventricular-hypophysial dopaminergic (PHDA) neurons suggesting that these neurons are tonically inhibited by endogenous...

journal_title：Brain research

authors： Wagner EJ,Moore KE,Lookingland KJ

更新日期：1994-10-17 00:00:00

abstract：:Near-infrared spectroscopy (NIRS) enables noninvasive measurement of concentration changes of oxy- and deoxy-hemoglobin. The present study investigated cerebral representations of motion illusion by NIRS and examined several experimental procedures to determine an efficient procedure that can shorten the experimental ...

journal_title：Brain research

authors： Hashimoto T,Minagawa-Kawai Y,Kojima S

更新日期：2006-03-10 00:00:00

abstract：:Reciprocal interactions between nitrergic and dopaminergic systems play a key role in the control of motor behavior. In the present study, we performed a comparative analysis of motor behavior (locomotor activity, catalepsy, rotational behavior) and monoamine metabolism in the striatum and substantia nigra of unilater...

journal_title：Brain research

authors： Czarnecka A,Konieczny J,Lenda T,Lorenc-Koci E

更新日期：2015-11-02 00:00:00

abstract：:The cellular origin and degree of collateralization of the subthalamostriatal, subthalamonigral and subthalamopallidal projections in the squirrel monkey (Saimiri sciureus) were studied using lectin-conjugated horseradish peroxidase (WGA-HRP), Nuclear yellow (NY) and Fast blue (FB) as retrograde tracers. In a first ex...

journal_title：Brain research

authors： Parent A,Smith Y

更新日期：1987-12-15 00:00:00

abstract：PURPOSE:Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter...

journal_title：Brain research

authors： Wang D,Li YH,Fu J,Wang H

更新日期：2016-10-01 00:00:00

abstract：:The effect of suprachiasmatic nucleus (SCN) ablation on rhythms in brain neurotransmitter receptors was studied. In control animals, the rhythms in the number of alpha-adrenergic and benzodiazepine receptors were circadian, whereas the rhythms in beta-adrenergic and acetylcholine receptors were ultradian. SCN ablation...

journal_title：Brain research

authors： Kafka MS,Marangos PJ,Moore RY

更新日期：1985-02-18 00:00:00

abstract：:Extracellular single unit recordings were made from various depths in the left olfactory bulb of ten anaesthetised, freely breathing adult hens (Gallus domesticus) using glass insulated tungsten microelectrodes. The 66 spontaneously active neurons recorded had widely variable firing rates (mean 4.9 spikes/s, range 0.1...

journal_title：Brain research

authors： McKeegan DE

更新日期：2002-03-01 00:00:00

abstract：:Long-term potentiation (LTP) can be initiated in CA1, but not in the dentate, region of slices from rats with bilateral subcortical deafferentation at 8 week survival time. At about one week survival time, LTP is present in the CA1 region of all and also in the dentate of about 50% of slices. The results suggest that ...

journal_title：Brain research

authors： Czéh G,Horváth Z,Czopf J

更新日期：1990-06-04 00:00:00

abstract：:The interposed nuclei (IN) of the intermediate cerebellum are critical components of the circuits that control associative learning of eyeblinks and other defensive reflexes in mammals. The IN, which represent the sole output of the intermediate cerebellum, receive massive GABAergic input from Purkinje cells of the ce...

journal_title：Brain research

authors： Parker KL,Zbarska S,Carrel AJ,Bracha V

更新日期：2009-10-06 00:00:00

abstract：:Previous research has suggested the potential involvement of the hypothalamic-pituitary-adrenal (HPA) axis in psychostimulant reinforcement. In particular, we have found significant correlations between electric footshock-induced increases in plasma corticosterone and the acquisition, or lack thereof, of intravenous c...

journal_title：Brain research

authors： Goeders NE,Guerin GF

更新日期：1996-05-25 00:00:00

abstract：:The mouse auditory neurons, hair cells and their supporting cells in the cochlea are considered to be generated mainly in the embryonic days and to be sustained throughout the whole life. In the present study, however, we observed that auditory ganglion cells in the spiral ganglia undergo apoptosis and mitosis in the ...

journal_title：Brain research

authors： Kamiya K,Takahashi K,Kitamura K,Momoi T,Yoshikawa Y

更新日期：2001-05-18 00:00:00

abstract：:Because the occurrence of rapid eye movement (REM) sleep is critically dependent upon an animal's thermal balance, acute pharmacological treatments may effect REM sleep through effects on thermoregulation. We describe how manipulating ambient temperature (T(a)) alters the REM sleep-suppressing effects of systemically-...

journal_title：Brain research

authors： Szymusiak R,Danowski J,McGinty D

更新日期：1994-02-04 00:00:00

abstract：:Central nervous system (CNS) disorders are important targets for gene therapy; however, delivery of therapeutic proteins and/or genes to the brain remains a major challenge due to the difficulty of efficiently delivering viral vectors across the blood-brain barrier (BBB). In the present work, we tested the ability of ...

journal_title：Brain research

authors： Miyake N,Miyake K,Yamamoto M,Hirai Y,Shimada T

更新日期：2011-05-10 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BMSCs) are a promising source for cell-based treatment of brain injury, but the therapy of BMSCs is restricted by low cell survival. We examined whether nerve growth factor (NGF) improve BMSCs viability in the brain with Fimbria-Fornix lesion (FF). After transduction of NGF ...

journal_title：Brain research

authors： Leng SL,Fan WG,Qu HG,Xu SC,Zhong WY,Zhang WY,Zeng JQ,Long DH,He HW

更新日期：2009-01-19 00:00:00

abstract：:The morphological basis of how visceral information from the nucleus of the solitary tract (NTS) is relayed from the parabrachial nucleus (PBN) to the central nucleus of the amygdala (Ce) was studied at the light and electron microscopic levels using the anterograde tracer, Phaseolus vulgaris leucoagglutinin (PHA-L), ...

journal_title：Brain research

authors： Jia HG,Rao ZR,Shi JW

更新日期：1994-11-14 00:00:00

abstract：:The impact of perinatal exposure to environmental tobacco smoke (ETS) on cognitive development is controversial. We exposed rhesus monkeys to ETS or filtered air (5 animals per group) beginning in utero on day 50 of pregnancy and continuing throughout postnatal testing. In infancy, we evaluated both groups for visual ...

journal_title：Brain research

authors： Golub MS,Slotkin TA,Tarantal AF,Pinkerton KE

更新日期：2007-06-02 00:00:00

abstract：:Rat central nervous system (CNS) tissue sections were immunostained by the peroxidase-anti-peroxidase (PAP) method using a rabbit serum directed against rat liver 5'-nucleotidase. In paraffin sections from the brains of 60-day-old rats 5'-nucleotidase immunoreactivity occurred in the same white-matter regions as myeli...

journal_title：Brain research

authors： Cammer W,Sacchi R,Kahn S

更新日期：1985-05-01 00:00:00