Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: comparison with rolipram.


:Cyclic nucleotide phosphodiesterase-4 (PDE4) is a component of signaling pathways involved in the mediation of antidepressant activity. Of the four PDE4 subtypes, PDE4D appears to be of particular importance, given the finding that PDE4D-deficient mice exhibit an antidepressant-like behavioral phenotype. In mouse hippocampus and cerebral cortex, the effects of repeated treatment with the antidepressants desipramine and fluoxetine or the PDE4 inhibitor rolipram on the expression of PDE4D was compared to that of PDE4A and PDE4B, the other two subtypes expressed in the brain. Expression of PDE4D was increased by all drugs tested, with the exception of desipramine in hippocampus. By contrast, these treatments affected PDE4A and PDE4B expression differentially. In hippocampus, antidepressants increased PDE4A and decreased PDE4B, whereas ROL decreased PDE4A and did not change PDE4B. In cerebral cortex, antidepressants increased PDE4A and did not change PDE4B, whereas ROL did not change PDE4A and increased PDE4B. 3H-Rolipram binding was increased in cytosolic, but not in membrane, fractions of cerebral cortex by all drugs tested; there were no changes observed in hippocampus. Overall, the present results suggest some species-dependence of the regulation of PDE4 subtypes, based on data obtained previously using rats. They also suggest that the PDE4D subtype may be of particular importance as an antidepressant target in that it is regulated by repeated treatment with both norepinephrine and serotonin reuptake inhibitors as well as by the PDE4 inhibitor rolipram, drugs that produce antidepressant effects via different neuropharmacological mechanisms.


Brain Res


Brain research


Dlaboga D,Hajjhussein H,O'Donnell JM




Has Abstract


2006-06-22 00:00:00














  • Studies of the in vivo catabolism of exogenous dopamine as infused through a push-pull cannula implanted in the rat caudate nucleus.

    abstract::In this report, using a push-pull perfusion technique, we examined in vivo the effects of exogenous dopamine (DA) on the output of neurochemical substances from the caudate nucleus (CN) of freely behaving rats. Exogenous DA, at concentrations of 10(-5) M, 5 x 10(-5) M and 10(-4) M, in modified Krebs-Ringer phosphate m...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chang GD,Ramirez VD

    更新日期:1989-03-06 00:00:00

  • Subdivision of primary afferents from passive cat muscle spindles based on a single slow-adaptation parameter.

    abstract::38 primary afferents originating from de-efferented cat tibialis anterior muscle spindles were investigated. Ramp-and-hold stretches of the host muscle were performed with a varying amount of muscle pre-stretch while recording the primary afferent discharges. From the discharge responses an interspike interval functio...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Awiszus F,Schäfer SS

    更新日期:1993-05-28 00:00:00

  • Effects of cyclooxygenase products of arachidonic acid metabolism on cutaneous nociceptive threshold in the rat.

    abstract::The nonsteroidal anti-inflammatory drugs are presumed to produce their analgesic effects by inhibiting the cyclooxygenase catalyzed metabolism of arachidonic acid to hyperalgesic prostanoids. This study examined the hyperalgesic effect of a range of prostaglandins. We found, employing the rat paw-withdrawal test, that...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Taiwo YO,Levine JD

    更新日期:1990-12-24 00:00:00

  • Subcommissural organ-Reissner's fiber complex of the teleost Clarias batrachus responds to GABA treatment.

    abstract::Subcommissural organ (SCO) is a highly specialized ependymal gland located in the roof of the third ventricle. The secretory products of the SCO, which condense to form Reissner's fiber (RF), were recently found to cross-react with the anti-calcitonin antibody. To understand the mechanisms regulating the formation of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Saha SG,Jain MR,Subhedar N

    更新日期:2000-01-10 00:00:00

  • Evidence for coexistence of serotonin and noradrenaline in sympathetic nerves supplying brain vessels of guinea pig.

    abstract::Nerve fibers containing 5-hydroxytryptamine (5-HT) were demonstrated immunohistochemically in the wall of pial vessels associated with the circle of Willis in the guinea pig. The fibers formed a network structure which was more dense in the rostral part of the arterial circle and its branches than in the caudal part. ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chang JY,Owman C,Steinbusch HW

    更新日期:1988-01-12 00:00:00

  • Locus coeruleus neurons in culture have a developmentally transient alpha 1 adrenergic response.

    abstract::Intracellular recordings from locus coeruleus neurons grown in explant cultures reveal age-related differences in the responses to iontophoretically applied noradrenaline. Cells grown in culture for more than 26 days exhibit a simple hyperpolarizing response while cells cultured for less than 26 days often have biphas...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Finlayson PG,Marshall KC

    更新日期:1986-03-01 00:00:00

  • Kainic acid responses and toxicity show pronounced Ca2+ dependence.

    abstract::Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that the channel activated by kainate is unusually influenced by Ca2+, excitotoxicity is Ca2+-dependent and...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hori N,Ffrench-Mullen JM,Carpenter DO

    更新日期:1985-12-09 00:00:00

  • Calcium dependency of excitatory chemical synaptic transmission in the frog cerebellum in vitro.

    abstract::Chemical synaptic transmission was studied with microelectrode techniques in isolated frog cerebella maintained in vitro. Purkinje cell (PC) EPSPs, elicited by selective monosynaptic electrical stimulation of both the parallel fiber (PF) and climbing fiber (CF) inputs, could be inverted by depolarizing (outward) curre...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hackett JT

    更新日期:1976-09-10 00:00:00

  • Dye and electrical coupling between frog motoneurons.

    abstract::Coupling between lumbar motoneurons in the isolated frog spinal cord was studied by using intracellular recordings and intracellular injections of Lucifer Yellow CH. Physiological studies revealed intra- and intersegmental, short latency electrical interactions between many motoneurons. Injections of Lucifer Yellow in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brenowitz GL,Collins WF 3rd,Erulkar SD

    更新日期:1983-09-12 00:00:00

  • Brain blood flow and extracerebral carotid circulation during sleep in rat.

    abstract::Cerebral blood flow (CBF) and blood flow (BF) in extracerebral head structures were measured during the sleep-wake cycle in rats using radioactive microspheres. While no statistically significant changes occurred in the transition from Waking to quiet sleep (also referred to as synchronized or non-REM Sleep), CBF incr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zoccoli G,Bach V,Cianci T,Lenzi P,Franzini C

    更新日期:1994-03-28 00:00:00

  • Time-frequency characteristics and dynamics of sleep spindles in WAG/Rij rats with absence epilepsy.

    abstract::In rat models of absence epilepsy, epileptic spike-wave discharges appeared in EEG spontaneously, and the incidence of epileptic activity increases with age. Spike-wave discharges and sleep spindles are known to share common thalamo-cortical mechanism, suggesting that absence seizures might affect some intrinsic prope...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sitnikova E,Hramov AE,Grubov V,Koronovsky AA

    更新日期:2014-01-16 00:00:00

  • Diffuse white matter response in trauma-injured brain to bone marrow stromal cell treatment detected by diffusional kurtosis imaging.

    abstract::Diffuse white matter (WM) response to traumatic brain injury (TBI) and transplantation of human bone marrow stromal cells (hMSCs) after the injury were non-invasively and dynamically investigated. Male Wistar rats (300-350 g) subjected to TBI were intravenously injected with 1 ml of saline (n = 10) or with hMSCs in su...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Li L,Chopp M,Ding G,Davoodi-Bojd E,Li Q,Mahmood A,Xiong Y,Jiang Q

    更新日期:2019-08-15 00:00:00

  • Effect of steroid competition and time on the uptake of (3H)corticosterone in the rat brain; an autoradiographic study.

    abstract::The localization of [3H]corticosterone in the brain and pituitary of the adrenalectomized rat was studied by autoradiography. Corticosterone was concentrated preferentially by neurons in the hippocampus, septum, amygdala, and neocortex, with the hippocampal and septal neurons having the greatest concentration. [3H]-Co...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rhees RW,Grosser BI,Stevens W

    更新日期:1975-01-10 00:00:00

  • Involvement of nociceptin/orphanin FQ and its receptor in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation.

    abstract::The neuropeptide nociceptin/orphanin FQ (N/OFQ), the endogenous agonist of the N/OFQ peptide receptor (NOP receptor), has been demonstrated to be involved in many physiological and pathological functions including pain regulation. In the present study, the involvement of N/OFQ-NOP receptor system in electroacupuncture...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fu X,Wang YQ,Wu GC

    更新日期:2006-03-17 00:00:00

  • Effect of maternal administration of allopregnanolone before birth asphyxia on neonatal hippocampal function in the spiny mouse.

    abstract::Clinically, treatment options where fetal distress is anticipated or identified are limited. Allopregnanolone is an endogenous steroid, that positively modulates the GABA(A) receptor, and that has anti-apoptotic and anti-excitotoxic actions, reducing brain damage in adult animal models of brain injury. We sought to de...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fleiss B,Parkington HC,Coleman HA,Dickinson H,Yawno T,Castillo-Melendez M,Hirst JJ,Walker DW

    更新日期:2012-01-18 00:00:00

  • Mechanical hyperalgesia in streptozotocin-diabetic rats is not sympathetically maintained.

    abstract::It has been suggested that the mechanism underlying the pain that occurs in patients with diabetic neuropathy may be similar to that mediating sympathetically maintained pain (SMP), such as occurs in patients with reflex sympathetic dystrophy. To evaluate this suggestion we have examined a model of diabetes mellitus, ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ahlgren SC,Levine JD

    更新日期:1993-07-09 00:00:00

  • Evoked and event related coherence of Alzheimer patients manifest differentiation of sensory-cognitive networks.

    abstract::In previous studies on Alzheimer's patients it was shown that, in frontal and parietal locations, delta and theta responses of AD patients were greatly reduced. The present study analyzed coherence functions in these highly affected frontal and parietal areas. Visual sensory and event related coherences of patients wi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Başar E,Güntekin B,Tülay E,Yener GG

    更新日期:2010-10-21 00:00:00

  • Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice.

    abstract::We have shown that, when an amyloid-beta peptide (Abeta) overproducing transgenic mouse model (PSAPP) of Alzheimer's disease (AD) is treated with a depleting antibody against CD40L, it causes marked attenuation of Abeta pathology associated with decreased amyloidogenic processing of amyloid precursor protein (APP) and...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Todd Roach J,Volmar CH,Dwivedi S,Town T,Crescentini R,Crawford F,Tan J,Mullan M

    更新日期:2004-07-23 00:00:00

  • Dietary omega 3 fatty acids and the developing brain.

    abstract::The omega-3 fatty acids are essential dietary nutrients and one of their important roles is providing the fatty acid with 22 carbons and 6 double bonds known as docosahexaenoic acid (DHA) for nervous tissue growth and function. Inadequate intakes of omega-3 fatty acids decrease DHA and increase omega-6 fatty acids in ...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Innis SM

    更新日期:2008-10-27 00:00:00

  • Slow age-dependent decline of doublecortin expression and BrdU labeling in the forebrain from lesser hedgehog tenrecs.

    abstract::In addition to synaptic remodeling, formation of new neurons is increasingly acknowledged as an important cue for plastic changes in the central nervous system. Whereas all vertebrates retain a moderate neuroproliferative capacity, phylogenetically younger mammals become dramatically impaired in this potential during ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Alpár A,Künzle H,Gärtner U,Popkova Y,Bauer U,Grosche J,Reichenbach A,Härtig W

    更新日期:2010-05-12 00:00:00

  • Distribution of parvalbumin-containing neurons and lectin-binding perineuronal nets in the rat basal forebrain.

    abstract::In sections of rat brain treated for Wisteria floribunda agglutinin (WFA) labelling the occurrence of parvalbumin (PARV)-, calbindin (CALB)- or choline acetyltransferase (ChAT) immunoreactivity was analyzed in the basal forebrain using dual-peroxidase and double-fluorescence methods. Only PARV-immunoreactive (-ir) neu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brauer K,Härtig W,Bigl V,Brückner G

    更新日期:1993-12-17 00:00:00

  • Evidence for the movement of fluid, macromolecules and ions from the brain extracellular space to the CSF.

    abstract::This report examines the effect of decreasing serum osmolality on movement into the ventricular system of fluid and of test material injected into the brain. Trace quantities of 22NaCl and 125I-labeled cat serum albumin (CSA) were injected into cerebral white matter of cats. The rates of cerebrospinal fluid volume flo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wald A,Hochwald GM,Gandhi M

    更新日期:1978-08-04 00:00:00

  • NMDA-receptor mediated electrical epileptogenesis in the organotypic culture of rat hippocampus.

    abstract::Extracellular field recordings were made in CA1 in the hippocampal explant cultures in oxygenated artificial cerebrospinal fluid. Schaffer collaterals were stimulated with 1-s trains of 60 Hz pulses every 10 min. Seizures were reliably elicited with progressive lengthening over 1-2 h. D-APV, an N-methyl-D-aspartate (N...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shin C,Tamaki Y,Wilson JT,Butler L,Sakaguchi T

    更新日期:1992-08-28 00:00:00

  • 31P NMR phospholipid characterization of intracranial tumors.

    abstract::Phospholipid extracts from 48 intracranial tumors were analyzed using 31P NMR. Phospholipids commonly identified in the tumor spectra included phosphatidylglycerol (PG), phosphatidic acid (PA), diphosphatidylglycerol (DPG), uncharacterized phospholipid (U), ethanolamine plasmalogen (EPLAS), phosphatidylethanolamine (P...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Merchant TE,van der Ven LT,Minsky BD,Diamantis PM,Delapaz R,Galicich J,Glonek T

    更新日期:1994-06-27 00:00:00

  • Primed-burst potentiation occludes the potentiation phenomenon and enhances the epileptiform activity induced by transient pentylenetetrazol in the CA1 region of rat hippocampal slices.

    abstract::The effects of pentylenetetrazol (PTZ) following induction of long-term potentiation (LTP) on population spikes in CA1 of hippocampal slices were investigated. Population spikes were evoked by activation of Schaffer collaterals with a range of stimulation intensities. LTP was induced using θ-pattern primed burst...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Omrani A,Fathollahi Y,Mohajerani HR,Semnanian S

    更新日期:2000-09-22 00:00:00

  • A possible role for BDNF, NT-4 and TrkB in the spinal cord and muscle of rat subjected to mechanical overload, bupivacaine injection and axotomy.

    abstract::Neurotrophins play a crucial role in the regulation of survival and the maintenance of specific functions for various populations of neurons. Neurotrophin-4 (NT-4) is most abundant in skeletal muscle, and is thought to promote sciatic nerve sprouting, inhibit agrin-induced acetylcholine receptor (AChR) clustering, evo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sakuma K,Watanabe K,Sano M,Uramoto I,Nakano H,Li YJ,Kaneda S,Sorimachi Y,Yoshimoto K,Yasuhara M,Totsuka T

    更新日期:2001-07-13 00:00:00

  • Blockade of the spinal excitatory effect of cAMP on the startle reflex by intrathecal administration of the isoquinoline sulfonamide H-8: comparison to the protein kinase C inhibitor H-7.

    abstract::Drugs thought to inhibit the actions of protein kinase C (PKC) and cAMP dependent protein kinase (A-kinase) were infused intrathecally into the subarachnoid space of the lumbar region of the spinal cord, and the effects on acoustic startle were measured. Previous work has shown that intrathecal infusion of drugs thoug...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Boulis NM,Davis M

    更新日期:1990-08-20 00:00:00

  • Organization of vasoactive intestinal peptide-like immunoreactive system in the brain, olfactory organ and retina of the zebrafish, Danio rerio, during development.

    abstract::The localization of vasoactive intestinal peptide (VIP)-like immunoreactivity was investigated in the brain, olfactory system and retina of the zebrafish, Danio rerio, during development and in juvenile specimens, by using the indirect immunofluorescence and the peroxidase-antiperoxidase methods. In 24 h post fertiliz...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mathieu M,Tagliafierro G,Angelini C,Vallarino M

    更新日期:2001-01-12 00:00:00

  • Somatostatin inhibition of adenylate cyclase activity in different brain areas.

    abstract::Somatostatin receptors have been identified in different brain areas but the characterization of their postreceptor effect is still lacking. In this study we analyze the somatostatin effect on adenylate cyclase activity in different brain regions, namely frontal cortex, striatum, hypothalamus and hippocampus. Somatost...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schettini G,Florio T,Meucci O,Landolfi E,Grimaldi M,Ventra C,Marino A

    更新日期:1989-07-17 00:00:00

  • Tyrosine hydroxylase expression within Balb/C and C57black/6 mouse locus coeruleus. I. Topological organization and phenotypic plasticity of the enzyme-containing cell population.

    abstract::Tyrosine hydroxylase phenotype expression was investigated in the catecholaminergic population of the locus coeruleus neurons of two pure inbred mouse strains, Balb/C and C57Black/6. Therefore, we have characterized the precise organization of tyrosine hydroxylase-expressing perikarya population, in control animals an...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ginovart N,Marcel D,Bezin L,Garcia C,Gagne C,Pujol JF,Weissmann D

    更新日期:1996-05-20 00:00:00