Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: comparison with rolipram.


:Cyclic nucleotide phosphodiesterase-4 (PDE4) is a component of signaling pathways involved in the mediation of antidepressant activity. Of the four PDE4 subtypes, PDE4D appears to be of particular importance, given the finding that PDE4D-deficient mice exhibit an antidepressant-like behavioral phenotype. In mouse hippocampus and cerebral cortex, the effects of repeated treatment with the antidepressants desipramine and fluoxetine or the PDE4 inhibitor rolipram on the expression of PDE4D was compared to that of PDE4A and PDE4B, the other two subtypes expressed in the brain. Expression of PDE4D was increased by all drugs tested, with the exception of desipramine in hippocampus. By contrast, these treatments affected PDE4A and PDE4B expression differentially. In hippocampus, antidepressants increased PDE4A and decreased PDE4B, whereas ROL decreased PDE4A and did not change PDE4B. In cerebral cortex, antidepressants increased PDE4A and did not change PDE4B, whereas ROL did not change PDE4A and increased PDE4B. 3H-Rolipram binding was increased in cytosolic, but not in membrane, fractions of cerebral cortex by all drugs tested; there were no changes observed in hippocampus. Overall, the present results suggest some species-dependence of the regulation of PDE4 subtypes, based on data obtained previously using rats. They also suggest that the PDE4D subtype may be of particular importance as an antidepressant target in that it is regulated by repeated treatment with both norepinephrine and serotonin reuptake inhibitors as well as by the PDE4 inhibitor rolipram, drugs that produce antidepressant effects via different neuropharmacological mechanisms.


Brain Res


Brain research


Dlaboga D,Hajjhussein H,O'Donnell JM




Has Abstract


2006-06-22 00:00:00














  • Toluene inhibits synaptic transmission without causing gross morphological disturbances.

    abstract::The effects of toluene on synaptic transmission and neuronal morphology were investigated using guinea pig hippocampal slices. Population spikes (PS) were elicited in granule cell layer by stimulation of the perforant path and antidromic potentials (AP) were evoked in the same locii by stimulation of mossy fibers. Tol...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ikeuchi Y,Hirai H

    更新日期:1994-11-21 00:00:00

  • Timing of 6-hydroxydopamine administration influences its effects on visual cortical plasticity.

    abstract::We recorded from the visual cortex of 4 groups of monocularly deprived kittens. Three groups were treated with intraventricular 6-hydroxydopamine (6-OHDA) at different times relative to monocular deprivation (MD). One group received only vehicle solution and MD. 6-OHDA caused the greatest decrease in plasticity in the...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Allen EE,Blakemore LJ,Trombley PQ,Gordon B

    更新日期:1987-03-01 00:00:00

  • Spinal cord noradrenergic neurons are activated in hypotension.

    abstract::Although norepinephrine-containing nerve terminals in the spinal cord synapse in the vicinity of sympathetic preganglionic cells, their effect on sympathetic outflow has remained unclear. Since survival during hypotension necessitates sustaining maximal sympathetic activity, we used experimental hypotension as a physi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Conlay LA,Maher TJ,Godley BF,Wurtman RJ

    更新日期:1986-06-04 00:00:00

  • Maturational changes of amino acid concentration in cerebrospinal fluid of the rat.

    abstract::The cisternal spinal fluid (CF), plasma, and brain stem concentrations of 6 amino acids were measured in suckling rats between birth and one months of age. Each of the amino acids studied had its distinctive maturational pattern of CF concentration. Presumably these amino acids have separate mechanisms of transport fr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Korobkin RK,Cutler RW

    更新日期:1977-01-01 00:00:00

  • Augmentation of short-term plasticity in CA1 of rat hippocampus after chronic ethanol treatment.

    abstract::The neurotoxic effects of chronic ethanol exposure were investigated in rat hippocampus by electrophysiological analysis of the Schaffer collateral-commissural input to stratum radiatum of CA1. Experimental animals were fed an ethanol-containing liquid diet for 20 weeks but were withdrawn from the special diet at leas...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Abraham WC,Hunter BE,Zornetzer SF,Walker DW

    更新日期:1981-09-28 00:00:00

  • A novel analytical brain block tool to enable functional annotation of discriminatory transcript biomarkers among discrete regions of the fronto-limbic circuit in primate brain.

    abstract::Fronto-limbic circuits in the primate brain are responsible for executive function, learning and memory, and emotions, including fear. Consequently, changes in gene expression in cortical and subcortical brain regions housing these circuits are associated with many important psychiatric and neurological disorders. Whi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dalgard CL,Jacobowitz DM,Singh VK,Saleem KS,Ursano RJ,Starr JM,Pollard HB

    更新日期:2015-03-10 00:00:00

  • Cross-linking of NCAM receptors on neurons induces programmed cell death.

    abstract::Programmed cell death has been implicated in the loss of neurons that occurs in many neurodegenerative diseases. This has led to an increased interest in the types of stimuli that can initiate neurons to undergo programmed cell death. Previously, we have shown that cross-linking of membrane receptors with the lectin c...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Azizeh BY,Cribbs DH,Kreng VM,Cotman CW

    更新日期:1998-06-15 00:00:00

  • Anticipatory changes of long-latency stretch responses during preparation for directional hand movements.

    abstract::We have investigated, in 9 normal subjects, the time course of amplitude changes in the automatic long latency stretch reflex of wrist flexors during the preparatory period as a function of the precued direction of hand movement. Subjects maintained right hand position against a weak force and learned to compensate pr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bonnet M

    更新日期:1983-11-28 00:00:00

  • Effects of insulin, insulin-like growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells.

    abstract::The identification of biologically important and chemically well-defined substances that can promote axon and dendrite formation would improve present understanding of the development of the nervous system. Physiological concentrations of insulin and insulin-like growth factor-II (IGF-II) reversibly enhanced neurite o...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Recio-Pinto E,Ishii DN

    更新日期:1984-06-08 00:00:00

  • Modulation of blood-brain barrier permeability by neutrophils: in vitro and in vivo studies.

    abstract::The blood-brain barrier (BBB) restricts solute permeability across healthy cerebral endothelial cells. However, during inflammation, permeability is increased and can lead to deleterious cerebral edema. Neutrophils are early cellular participants in acute inflammation, but their effect on BBB permeability is unclear. ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Joice SL,Mydeen F,Couraud PO,Weksler BB,Romero IA,Fraser PA,Easton AS

    更新日期:2009-11-17 00:00:00

  • Different epileptogenic activities of murine and ovine corticotropin-releasing factor.

    abstract::The behavioral and EEG effects of rat and ovine corticotropin releasing factor (r- and o-CRF) were compared. Both peptides were injected intracerebroventricularly into rats through chronically implanted cannulae. At the doses of 0.1 and 1 microgram both peptides activated the EEG and stimulated motor activity. At the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Marrosu F,Mereu G,Fratta W,Carcangiu P,Camarri F,Gessa GL

    更新日期:1987-04-07 00:00:00

  • Intracellular plasma proteins in human fetal choroid plexus during development. II. The distribution of prealbumin, albumin, alpha-fetoprotein, transferrin, IgG, IgA, IgM, and alpha 1-antitrypsin.

    abstract::Individual choroid plexuses of human fetal brain at different developmental stages were investigated by an indirect immunoperoxidase technique. The number and distribution of prealbumin-, albumin-, alpha-fetoprotein-, transferrin-, IgG-, IgA-, IgM- and alpha 1-antitrypsin-containing choroid plexus epithelial cells wer...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jacobsen M,Jacobsen GK,Clausen PP,Saunders NR,Møllgård K

    更新日期:1982-02-01 00:00:00

  • Effect of chronic sympathetic denervation on cerebrovascular hypertrophy during the development of hypertension in rats.

    abstract::The present study was designed to examine the trophic effect of sympathetic nerves on cerebrovascular hypertrophy in developmental hypertension. Unilateral superior cervical ganglionectomy was performed in spontaneously hypertensive rats at 4 weeks of age, and wall-to-lumen ratios of cerebral arteries were determined ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sadoshima S,Fujii K,Yao H,Ibayashi S,Fujishima M

    更新日期:1986-08-06 00:00:00

  • Involvement of cholinergic neurons in the release of dopamine elicited by stimulation of mu-opioid receptors in striatum.

    abstract::The involvement of striatal cholinergic neurons in the release of dopamine (DA) elicited by the mu-opioid receptor agonist DAGO ([D-Ala2, NMePhe4-Gly5(ol)]enkephalin) was explored. The striatal release of DA was measured by microdialysis in rats anesthetized with chloral hydrate. When infused in the striatum, through ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dourmap N,Clero E,Costentin J

    更新日期:1997-02-28 00:00:00

  • Organization of the intercollicular pathway in rat.

    abstract::The intercollicular pathway of the rat was studied using autoradiographic (ARG) and horseradish peroxidase (HRP) tracing techniques. The HRP experiments demonstrated that the cells of origin of the intertectal pathway were located primarily in the rostral stratum griseum intermediale ( SGI ), stratum album intermedium...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yamasaki DS,Krauthamer G,Rhoades RW

    更新日期:1984-05-23 00:00:00

  • Dopaminergic regulation of prolactin and growth hormone synthesis in rat pituitary tumor cells.

    abstract::The dopaminergic regulation of prolactin (PRL) and growth hormone (GH) synthesis were studied in monolayer cultures of rat pituitary tumor (GH3) cells. PRL synthesis could not be inhibited by dopamine at concentrations ranging from 10(-9) to 10(-5) M. Bromocriptine inhibited PRL synthesis only at the very high concent...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cheung CY,Melmed S,Braunstein GD

    更新日期:1983-06-27 00:00:00

  • Cycloheximide activation of the lordotic response in low-dose, estrogen-treated ovariectomized rats: evidence for modulating inhibitory influences of the limbic system on sexual behavior.

    abstract::This study tested the effect on intracranially injected cycloheximide (CHX), an inhibitor of protein synthesis, on facilitation of sexual receptivity in ovariectomized rats. The rats received 0.5 microgram estradiol benzoate (EB), s.c. once daily on days 8 through 12 after ovariectomy (OVX). Either CHX (in 0.5 microli...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Renner KJ,Bast JD,Purcell ES,Quadagno DM

    更新日期:1981-10-19 00:00:00

  • Cortical spreading depression reduces paraventricular activation induced by hippocampal neostigmine injection.

    abstract::The firing rate of the neurons of the hypothalamic paraventricular nucleus, the temperatures of the interscapular brown adipose tissue and of the colon (TIBAT and Tc) were monitored in 24 urethane-anesthetized male Sprague-Dawley rats divided into four groups. These variables were measured before and after hippocampal...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Monda M,Viggiano A,Sullo A,De Luca V

    更新日期:1999-04-03 00:00:00

  • Hypothalamic deoxyribonucleases and DNA content during development of the androgenized female rat.

    abstract::The DNA content and activity of acid and alkaline deoxyribonucleases (DNases) were measured through age 60 days in the hypothalamus of female rats injected s.c. with 1.25 mg testosterone propionate 48 h after birth. DNA significantly increases through age 60 days, however, androgenization does not affect the DNases or...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Litteria M

    更新日期:1985-02-01 00:00:00

  • Transient elevation of intrasynaptosomal free calcium by putrescine.

    abstract::The role of polyamines in the regulation of free intrasynaptosomal Ca2+, [Ca2+]i was studied. After preincubation of rat brain synaptosomes with 5 mM difluormethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, the K+-induced increase of [Ca2+]i was 33% less than that in non-treated synaptosome...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Komulainen H,Bondy SC

    更新日期:1987-01-13 00:00:00

  • Localization of alpha-bungarotoxin binding sites in synapses of the developing chick retina.

    abstract::Alpha-bungarotoxin binding sites in chick retina from 12 days in ovo to hatching, were visualized at the ultrastructural level by use of a 1:1 conjugate of horseradish peroxidase with alpha-bungarotoxin. At all stages binding sites in the inner plexiform layer were localized in synapses, predominantly on or near the p...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Daniels MP,Vogel Z

    更新日期:1980-11-10 00:00:00

  • Chromatin binding of estradiol in the hypothalamus and cortex of male and female rats.

    abstract::Gonadal steroids are thought to act by activation of the genome following cytoplasmic binding, translocation of the hormone--receptor complex to the nucleus and chromatin binding at specific acceptor sites. This study examined the kinetics of chromatin binding of estradiol by hypothalamic and cortical cells of adult g...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Whalen RE,Olsen KL

    更新日期:1978-08-18 00:00:00

  • Antimitotic drugs that enhance neuronal survival in olfactory bulb cell cultures.

    abstract::Cell cultures of olfactory bulb from 2-3-day-old rats were used to evaluate 6 antimitotic drugs for their effects on neuronal survival. In cultures grown in medium without drugs for 7 days, neurons died as a layer of non-neuronal cells proliferated. A series of experiments were performed to determine dilutions and exp...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Burry RW

    更新日期:1983-02-21 00:00:00

  • Zinc: effect and interaction with other cations in the cortex of the rat.

    abstract::Zinc and other cations were iontophoretically applied to neurones in the frontoparietal cortex of urethane-anaesthetised rats and their effect on the activity of these cells was examined. Slow and often prolonged increases in firing rate occurred in 45.2% of neurones after zinc application and 72.7% after barium. Calc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wright DM

    更新日期:1984-10-08 00:00:00

  • Does the sight of physical threat induce a tactile processing bias? Modality-specific attentional facilitation induced by viewing threatening pictures.

    abstract::Threatening stimuli are thought to bias spatial attention toward the location from which the threat is presented. Although this effect is well-established in the visual domain, little is known regarding whether tactile attention is similarly affected by threatening pictures. We hypothesised that tactile attention migh...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Van Damme S,Gallace A,Spence C,Crombez G,Moseley GL

    更新日期:2009-02-09 00:00:00

  • Mediation of insulin hyperphagia by specific central opiate receptor antagonists.

    abstract::The hyperphagic properties of insulin (10 U/kg, s.c.) were transiently (2h) and dose-dependently inhibited (30%) by central pretreatment with naltrexone (20-50 micrograms, i.c.v.). The irreversible mu opioid antagonist, beta-funaltrexamine (B-FNA, 20 micrograms, i.c.v.) significantly inhibited insulin hyperphagia by 2...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Beczkowska IW,Bodnar RJ

    更新日期:1991-05-03 00:00:00

  • Intracellular pH and some membrane characteristics of cultured carotid body glomus cells.

    abstract::Clusters of carotid body (glomus) cells cultured from a few days to 3 weeks, maintained their morphological characteristics during this period. The resting potential (Em) and input resistance (Ro) did not change for 2 weeks but both declined afterwards. The intracellular pH (pHi) of glomus cells, measured with glass m...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: He SF,Wei JY,Eyzaguirre C

    更新日期:1991-05-03 00:00:00

  • Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein.

    abstract::Missense mutations of presenilin 1 (PS-1) and presenilin 2 (PS-2) genes cause the majority of early-onset familial forms of Alzheimer's disease (AD). We previously characterized the distribution of the PS-1 protein in the mouse brain by immunohistochemistry using an antibody directed against an epitope located in the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Blanchard V,Czech C,Bonici B,Clavel N,Gohin M,Dalet K,Revah F,Pradier L,Imperato A,Moussaoui S

    更新日期:1997-05-30 00:00:00

  • Sex-different effect of angiotensin II type 2 receptor on ischemic brain injury and cognitive function.

    abstract::We previously reported that angiotensin II type 2 (AT(2)) receptor signaling prevents neural damage and cognitive impairment after focal cerebral ischemia. We investigated the possible roles of the AT(2) receptor in the sex difference, focusing on cognitive function and ischemic brain damage using AT(2) receptor-defic...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sakata A,Mogi M,Iwanami J,Tsukuda K,Min LJ,Fujita T,Iwai M,Ito M,Horiuchi M

    更新日期:2009-12-01 00:00:00

  • Effects of the GABA agonists baclofen and THIP on long-term compensation in hemilabyrinthectomised rats.

    abstract::Horizontal eye movements, elicited by sinusoidal rotation in darkness, were recorded with a magnetic search coil technique in pigmented rats, hemilabyrinthectomised 8-12 weeks before the investigation. Separate gains during rotation towards the lesioned side (LS) and the intact side (IS) were calculated by a computer ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Magnusson AK,Eriksson B,Tham R

    更新日期:1998-06-08 00:00:00