Abstract：
:Intracellular recordings of the spontaneous activity were obtained from neurons in long-term cultures from the area of the supraoptic nucleus of rats. The effects of various substances known from in situ studies to cause vasopressin release were analyzed. Application of nicotine or acetylcholine induced a transition from a random to a phasic discharge pattern. Similar alterations in firing patterns were observed with enkephalin analogues, an effect which was blocked by the opiate antagonist, naloxone. Glutamate excited hypothalamic neurons in a dose-dependent manner, but did not induce phasic firing. Angiotensin II increased the firing rate in randomly firing cells and the duration of bursts in phasic cells. In an attempt to identify the transmitter(s) involved in the generation of phasic activity, several antagonists to excitatory transmitters were applied. Of the agents tested, only saralasin reduced the duration of bursts, but it is questionable whether this effect is due to its angiotensin-antagonistic property.
journal_name
Brain Resjournal_title
Brain researchauthors
Gähwiler BH,Dreifuss JJdoi
10.1016/0006-8993(80)90174-2subject
Has Abstractpub_date
1980-07-14 00:00:00pages
415-25issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(80)90174-2journal_volume
193pub_type
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