Abstract：
:We investigated the effect of Cerebrospinal Fluid (CSF) from sporadic Amyotrophic Lateral Sclerosis patients (SALS-CSF) on motor neuron-like cells to delineate the pathomechanism of SALS. Exposure of NSC-34 cells to SALS-CSF caused lower viability, reduction in differentiation and enhanced lactate dehydrogenase activity. Additionally, reduced choline acetyl transferase expression alongside intracellular aggregation of phosphorylated neurofilaments was prominently seen. The aggregates were immunopositive for ubiquitin. These findings are comparable to the pathological changes seen in the postmortem tissue of ALS patients. Unlimited supply of NSC-34 cells and their vulnerability to SALS-CSF render them to be a good bioassay system to identify new therapeutic agents conferring protection to motor neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Vijayalakshmi K,Alladi PA,Sathyaprabha TN,Subramaniam JR,Nalini A,Raju TRdoi
10.1016/j.brainres.2009.01.041subject
Has Abstractpub_date
2009-03-31 00:00:00pages
122-33eissn
0006-8993issn
1872-6240pii
S0006-8993(09)00175-9journal_volume
1263pub_type
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