Abstract：
:We have used the post-embedding immunogold labelling method using antibodies to gamma-aminobutyric acid (GABA) to obtain quantitative data on the distribution, frequency, postsynaptic targets and ultrastructural characteristics of GABA-immunoreactive (GABA-IR) boutons in the trigeminal motor nucleus of rats. We have also combined this method with horseradish peroxidase tracing to obtain specific evidence for termination of some GABA-IR boutons onto identified jaw-elevator motoneurones. Twenty-eight percent of all synapses in the motor nucleus involved GABA-IR boutons. Seventy-three percent of the GABA-IR boutons formed axo-dendritic synapses, 13% axo-somatic synapses and 14% axo-axonic synapses. Ninety-three percent of GABA-IR boutons formed symmetrical synapses. Overall, 58% of all boutons contained only flattened vesicles, while 26% contained round vesicles and 16% a mixture of vesicle types. Measurements of bouton cross sectional area, apposition length, and active zone length were obtained from serial reconstructions of 15 GABA-IR boutons and 30 unlabelled boutons. In each case mean values for GABA-IR boutons were significantly smaller than those for nonlabelled boutons.
journal_name
Brain Resjournal_title
Brain researchauthors
Saha S,Appenteng K,Batten TFdoi
10.1016/0006-8993(91)90757-msubject
Has Abstractpub_date
1991-10-04 00:00:00pages
128-38issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(91)90757-Mjournal_volume
561pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Distribution of adult T cell leukemia derived factor (ADF/TRX), a human thioredoxin homologue, was studied by immunohistochemistry in gerbil brain during reperfusion after transient cerebral ischemia. In control brains, immunoreactivity was observed widely in the central nervous system, including the ependyma, tanycyt...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90130-f
更新日期：1993-10-15 00:00:00
abstract：:The cognitive reserve hypothesis proposes that the brain actively attempts to cope with age-related changes by using pre-existing cognitive networks (neural reserve) or enlisting compensatory processes (neural compensation). In a context of visual selective attention, the current study compared task-related activation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.061
更新日期：2012-05-15 00:00:00
abstract：:Previous studies using the technique of microinjection into brain nuclei indicated that the periaqueductal gray (PAG), nucleus accumbens, habenula and amygdala play an essential role in pain modulation and that these nuclei possibly act through a 'mesolimbic neural loop' to exert an analgesic effect, in which Met-enke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91685-t
更新日期：1991-12-06 00:00:00
abstract：:The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous l-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial role in regulating nociceptive transmission. In contrast, the ester-type LA procaine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.12.021
更新日期：2017-02-15 00:00:00
abstract：:Recent evidence indicates that the superior colliculus (SC), in addition to its functions in sensory detection, also participates in controlling the generalized activation state of the forebrain, as measured by the electroencephalogram (EEG) or electrocorticogram (ECoG). The mechanisms by which the SC modulates forebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04062-3
更新日期：2003-02-21 00:00:00
abstract：:The distribution of radioactivity after injection of [3H]testosterone was studied in the forebrain of adult mice by thaw-mount autoradiography. Nuclear labeling was high in neurons in the dorsal part of the medial nucleus of the amygdala and in the dorsocaudal part of the bed nucleus of the stria terminalis. Low nucle...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90630-x
更新日期：1986-11-12 00:00:00
abstract：:Intraocular injections of several different retrograde tracers were made in albino rats. Retrogradely filled neurons were observed in two locations: the medial pretectal area and the contralateral periaqueductal grey matter, indicating that the pretectum and the mesencephalon are sources of centrifugal innervation to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90046-0
更新日期：1985-02-11 00:00:00
abstract：:Wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) was used to study transneuronal transport in the developing rat visual pathways. Intraocular injections of WGA-HRP were made in neonatal albino rat pups at different ages from the day of birth, postnatal day 0 (P0), to one month of age. Transneuronal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90087-9
更新日期：1988-01-01 00:00:00
abstract：:Applying light mechanical stimulations to the oral structures, multi-unit recordings (MUR) were performed, and receptive fields of neurons were defined in the somatosensory cortex S I of the cat. Oral representation was confirmed in the circumscribed area of the anterior coronal gyrus rostral to the facial area in the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90739-6
更新日期：1987-04-14 00:00:00
abstract：:Estrogen has previously been shown to significantly change sympathetic and parasympathetic system output via an action within the central nuclei responsible for regulating autonomic tone. These estrogen-induced changes were observed within 30 min of systemic administration and could be blocked by the direct microinjec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03387-0
更新日期：2003-11-14 00:00:00
abstract：:Application of horseradish peroxidase (HRP) to the proximal stump of the transected infraorbital (IO) nerve in the orbit was employed in normal adult rats to demonstrate the ganglionic representation of and brainstem innervation by the trigeminal (V) branch which supplies primarily the mystacial vibrissae. In the V ga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90970-8
更新日期：1983-06-13 00:00:00
abstract：:Immunohistochemical studies of a peroxisomal enzyme, bifunctional protein, were performed on human brains (occipital cortex, cerebellum, pons) from fetus to young adult. Bifunctional protein-positive neurons appeared at 23-25 weeks of gestation in the facial nuclei of pons, at 27-28 weeks in the occipital cortex and P...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91878-3
更新日期：1994-03-21 00:00:00
abstract：:Recently, cerebral blood flow changes were re-discussed to contribute to tissue protection after preconditioning. In the present study, we demonstrate increased vessel diameters of the leptomeningeal anastomoses after hypoxic preconditioning by visualization of the brain angioarchitecture using the latex perfusion tec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.081
更新日期：2006-10-18 00:00:00
abstract：:The present work shows the existence of adenosine-dependent cyclic adenosine monophosphate (AMP) accumulation in the chick optic tectum. When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90016-2
更新日期：1987-09-01 00:00:00
abstract：:The myosin S-1 subfragment was used to label actin filaments in the developing rat brain. The results show actin filaments present throughout the dendritic region with highest concentrations within growth cones and regions of spine development. Between 6 and 25 days postnatal, spines became more complex and actin fila...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90253-1
更新日期：1986-06-01 00:00:00
abstract：:Estrogens exert a wide variety of actions on reproductive and non-reproductive functions. These effects are mediated by slow and long lasting genomic as well as rapid and transient non-genomic mechanisms. Besides the host of studies demonstrating the role of genomic actions at the physiological and behavioral level, m...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2006.07.098
更新日期：2006-12-18 00:00:00
abstract：:Spontaneously firing units were recorded extracellularly from the hippocampus of anesthetized rats, and autocorrelograms were conventionally constructed. These conventional autocorrelograms were sorted into frequency-specific autocorrelograms according to the instantaneous firing frequency of the spike at Deltat=0, wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.050
更新日期：2007-02-16 00:00:00
abstract：:Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CB1 re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.031
更新日期：2010-06-04 00:00:00
abstract：:The effect of lowered brain glutathione content on the glutamate release following cerebral ischemia was investigated. Diethylmaleate (4 mmol/kg, i.p.), a commonly used chemical reagent for tissue glutathione depletion, significantly reduced the ischemia-induced glutamate release. The release of another excitatory ami...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00992-y
更新日期：1995-11-06 00:00:00
abstract：:The primary objective of this study was to test the hypothesis that intravenous administration of autologous bone marrow cells could improve functional recovery after middle cerebral artery occlusion (MCAO) for 45 min in the rat and to determine specific time windows for efficacy. Mononuclear cells from autologous bon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.084
更新日期：2004-05-08 00:00:00
abstract：:Structural changes induced by high frequency (HF) stimulation on granule cells of the hippocampal dentate gyrus of rats with inborn high (HP) and low (LP) learning capacity was examined in this study. Two types of axodendritic synapses were processed morphometrically; the axonal bouton on dendritic shafts and those ma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90371-h
更新日期：1990-12-24 00:00:00
abstract：:In order to characterize the neurons responsible for ACTH release and the suppression produced by adrenocortical steroids, we have studied the pharmacological sensitivity of neurons in the region containing the highest concentration of corticotropin releasing factor (CRF) in the brain and probably responsible for most...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90368-2
更新日期：1983-08-01 00:00:00
abstract：:Cardiac arrest-induced cerebral hypoxic injury could induce posthypoxic movement disorders. Here we investigated the effects of memantine, an NMDA receptor channel blocker, on the neurodegeneration occurred in an established rat model of posthypoxic myoclonus. We found that administration of memantine for 7 days signi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.076
更新日期：2007-02-16 00:00:00
abstract：:Electrophysiological recordings in rat brain slices have been used to study the actions of adenosine on striatal neurons and striatal excitatory amino acid neurotransmission originating in the cortex or the thalamus. Adenosine had no effects on membrane properties of striatal neurons. Adenosine and the A1 agonist N6-C...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01060-3
更新日期：1997-12-05 00:00:00
abstract：:Gulf War Illness (GWI) is a chronic disease that affects the 1991 Gulf War (GW) veterans for which treatment is lacking. It has been hypothesized that drugs used to protect military personnel from chemical attacks and insects during the war: pyridostigmine bromide (PB),N, N-diethyl-m-toluamide (DEET), and permethrin (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.12.030
更新日期：2018-02-15 00:00:00
abstract：:A study was undertaken of the role of the external lateral parabrachial subnucleus (PBNLe) in flavor preferences induced by the intragastric administration of predigested/cephalic food. These preferences were developed using two different learning procedures, concurrent and sequential. In the concurrent procedure, two...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03032-9
更新日期：2002-09-20 00:00:00
abstract：:In the present study, we observed chronological changes of antioxidant-like protein 1 (AOP-1) in the gerbil hippocampal CA1 region after 5 min of transient forebrain ischemia using immunohistochemistry and western blot. AOP-1 was significantly altered in the CA1 region after transient ischemia. In the sham-operated gr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.022
更新日期：2005-11-16 00:00:00
abstract：:We examined for immediate and persistent changes in nAChRs in cerebral cortex, thalamus and striatum of male rats caused by prenatal exposure to nicotine from gestational day 3 to postnatal day 10 (PN10), and how such exposure affected the responses of adolescents to subsequent nicotine challenge. Receptor numbers wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.076
更新日期：2009-01-23 00:00:00
abstract：:The HSD2 (11-beta-hydroxysteroid dehydrogenase-type 2 enzyme) containing neurons of the nucleus tractus solitarius (NTS) become activated during low-sodium and high-aldosterone states such as hypovolemia. This response may be due to hormonal and/or neural signals. Hormonal signals may activate neurons in the area post...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.098
更新日期：2009-12-08 00:00:00
abstract：:This paper reports studies on the biotransformation of the nonapeptide arginine-vasotocin (AVT) by both rat and chicken brain synaptic membranes. The fragments which were formed during digestion of AVT1-9, were isolated by high pressure liquid chromatography (HPLC) and chemically characterized by amino acid compositio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90419-5
更新日期：1983-09-19 00:00:00
