Abstract：
:The distribution of radioactivity after injection of [3H]testosterone was studied in the forebrain of adult mice by thaw-mount autoradiography. Nuclear labeling was high in neurons in the dorsal part of the medial nucleus of the amygdala and in the dorsocaudal part of the bed nucleus of the stria terminalis. Low nuclear uptake occurred in the medial preoptic nucleus, in mediobasal hypothalamic nuclei and in the ventromedial amygdala. Nuclear concentration of radioactivity was not influenced by competition with dihydrotestosterone and was present in androgen receptor deficient Tfm mice. It was totally abolished by competition with estradiol. This indicates that in the brain [3H]testosterone is converted to estrogenic metabolites which bind to estrogen receptors. Nuclear labeling after [3H]testosterone was restricted to a few of the brain nuclei, known to contain estrogen receptors indicating that aromatization occurs only in select regions. The results suggest that testosterone acts on the brain via estrogen receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Schleicher G,Stumpf WE,Morin JK,Drews Udoi
10.1016/0006-8993(86)90630-xsubject
Has Abstractpub_date
1986-11-12 00:00:00pages
290-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)90630-Xjournal_volume
397pub_type
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