Abstract：
:In this study, noradrenergic (NE) terminals in the dorsal raphe were identified by [3H]NE electron microscopic (EM) autoradiography. Lesioning of NE terminals by treatment with the selective catecholamine neurotoxin, 6-hydroxydopamine produced a marked decrease in NE-labelled terminals. [3H]5-HT EM autoradiography of the dorsal raphe produced labelling of cell bodies, dendrites and axons but labelled terminals with synaptic junctions were not observed. Serotonergic (5-HT) neurons were identified at an early stage of degeneration following treatment with the selective 5-HT neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT). When both [3H]NE autoradiography and 5,7-DHT lesioning were combined, a majority of NE-labelled terminals, which formed synaptic specializations, innervated degenerating dendrites. These findings suggest that NE terminals directly innervate 5-HT cells in the dorsal raphe.
journal_name
Brain Resjournal_title
Brain researchauthors
Baraban JM,Aghajanian GKdoi
10.1016/0006-8993(81)90646-6subject
Has Abstractpub_date
1981-01-05 00:00:00pages
1-11issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(81)90646-6journal_volume
204pub_type
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