Abstract：
:The immunohistochemical distribution of clusterin (SP40,40, SGP-2) was determined in Alzheimer disease (AD) and normal human brain tissue and compared with the distributions of vitronectin, protectin and the complement membrane attack complex (MAC). Antibodies to all four proteins showed staining of dystrophic neurites and neuropil threads in AD tissue, and residual serum in normal tissue, but only antibodies to clusterin and vitronectin strongly stained amyloid deposits in senile plaques. The clusterin antibody also showed punctate staining of some normal appearing AD pyramidal neurons, and very scattered staining of intracellular neurofibrillary tangles. Clusterin, vitronectin and protectin are all believed to inhibit membrane insertion by the MAC, and these data are consistent with upregulation of all three proteins in response to MAC formation in AD, and with a neuronal origin of clusterin.
journal_name
Brain Resjournal_title
Brain researchauthors
McGeer PL,Kawamata T,Walker DGdoi
10.1016/0006-8993(92)90071-gsubject
Has Abstractpub_date
1992-05-08 00:00:00pages
337-41issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(92)90071-Gjournal_volume
579pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The effects of midazolam, one of the most popular benzodiazepines, on synaptic transmissions were compared with intracellular recordings between CA1 pyramidal cells (CA1-PCs) and dentate gyrus granule cells (DG-GCs) in rat hippocampal slices. First, we studied the effects of midazolam on orthodromically evoked spikes,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00920-7
更新日期：1997-10-31 00:00:00
abstract：:Taurine transport into six brain regions of equithesin-anesthetized rats was studied by the in situ brain perfusion technique. This technique gives both accurate measurements of cerebrovascular amino acid transport and allows complete control of the perfusate amino acid composition. Final wash procedure showed that ta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00648-a
更新日期：1995-09-18 00:00:00
abstract：:The in vitro model presented provides an approach to study the nature of cell volume control as well as of swelling mechanisms under pathophysiological conditions. Pertinent parameters of cell volume control can be analyzed in isolation due to a virtually infinite extracellular environment precluding secondary effects...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90180-4
更新日期：1983-11-21 00:00:00
abstract：:Intracellular Ca2+ concentration ([Ca2+]i) was measured in neurons, acutely dissociated from the rat dorsal raphe nucleus (DRN), with the fluorescent calcium probe Fluo3. Nociceptin (300 nM) had no effect on resting [Ca2+]i but reduced the magnitude of the [Ca2+]i transient triggered by depolarization in 90% of neuron...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01965-4
更新日期：1999-10-23 00:00:00
abstract：:Hippocampal slices were taken from 7-day-old rats and maintained in vitro for 1-3 weeks. The organization of intrahippocampal connections in these explants was studied by placing onto the tissue small crystals of horseradish peroxidase (HRP) soaked with the detergent Nonidet. Antero- and retrograde transport of HRP wa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91448-4
更新日期：1986-08-13 00:00:00
abstract：:Morphine is one of the most potent analgesics used in medicine and it's long-term use is associated with the risk of the state of dependence. The cessation of chronic morphine administration leads to withdrawal signs which are associated with neurotransmitter dysregulations within mesolimbic system. Adenosine 5'-triph...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.05.025
更新日期：2019-09-15 00:00:00
abstract：:Striatal D2 dopamine receptor concentrations were shown to decrease 30-35% during the lifespan of Wistar rats as assessed both radiochemically and autoradiographically. Binding densities and degree of age-change varied within the striatum; the latter ranging from 17 to 44% in 4 different regions. Overall neuronal loss...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91108-6
更新日期：1989-10-02 00:00:00
abstract：:Central catecholamine alterations associated with immune activity are similar to those seen following stressor exposure. Inasmuch as aged animals exhibit more pronounced stressor-provoked alterations of central amines relative to younger animals, it was of interest to determine whether immune challenge would similarly...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90284-4
更新日期：1994-12-12 00:00:00
abstract：:The distribution of inositol 1,4,5-trisphosphate (InsP3) 3-kinase was studied in the adult rat brain, using polyclonal antibodies raised against the purified 50,000-Da rat brain enzyme by immunohistochemistry and Western blot, in addition to enzymatic assay. Immunohistochemically, the enzyme was detected in neurons, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91622-8
更新日期：1991-01-25 00:00:00
abstract：:We have examined the saturation features (Kd and Bmax) of [3H]naloxone binding in rat brain regions in cytoarchitectonically intact tissues of naive, morphine dependent and precipitated withdrawal states using quantitative film autoradiography. Sixty-one saturation experiments in 13 regions of naive rat brains yielded...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91237-5
更新日期：1985-12-23 00:00:00
abstract：:Previous studies from our laboratory suggest that apolipoprotein (apoE), a lipid transporting protein, facilitates olfactory nerve regeneration. We have shown that apoE is enriched in the olfactory nerve and around the glomeruli of the olfactory bulb (OB). The studies reported herein were undertaken to identify possib...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.12.036
更新日期：2007-03-16 00:00:00
abstract：:Responsiveness of single inferotemporal (IT) neurons to a tone as a start or warning signal in each test trial was investigated in monkeys performing visual discrimination of 4 patterns. It was found that the same IT neurons were responsive to both auditory signal and visual discriminanda with different response chara...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(87)80031-8
更新日期：1987-04-28 00:00:00
abstract：:Many of our daily movements use visual information to guide our arms toward objects of interest. Typically, these visually guided movements involve first focusing our gaze on the intended target and then reaching toward the direction of our gaze. The literature on eye-hand coordination provides a great deal of evidenc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.057
更新日期：2009-08-11 00:00:00
abstract：:Muscle spindle activity has been shown to decrease in the sustained contracting muscle. The effect has been assumed to result from a declining fusimotor drive. Since accumulation of metabolites including H(+), lactate and CO(2) might also affect the receptor in the fatiguing muscle, the impulse activity of muscle spin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.059
更新日期：2005-05-10 00:00:00
abstract：:It was previously reported that chronic food restriction and maintenance of rats at 75-80% of initial body weight enhanced the reward-potentiating effect of D-amphetamine in the lateral hypothalamic self-stimulation (LHSS) paradigm. Moreover, the enhancement reversed in parallel with body weight recovery when ad libit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.002
更新日期：2006-05-04 00:00:00
abstract：:Diverse neuropsychiatric diseases were recently linked to specific anti-neuronal autoantibodies targeting synaptic proteins. Symptoms can range from epileptic seizures to cognitive impairment to movement disorders, commonly responding to treatment with immunotherapy. Several of these autoantibodies target inhibitory s...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.09.009
更新日期：2018-12-15 00:00:00
abstract：:To study the regulation of hypothalamic vasopressin (VP) and oxytocin (OT) gene expression in relation to the development of hypertension, levels of VP mRNA and OT mRNA were determined in spontaneously hypertensive rats (SHR). Differences in VP and OT mRNA content of the supraoptic nucleus (SON) and paraventricular nu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(88)90039-3
更新日期：1988-12-01 00:00:00
abstract：:The analgesic effect and its mechanism of electroacupuncture (EA) on inflammatory pain, especially in the rat model of collagen-induced arthritis (CIA), have not yet been studied. This study was designed to investigate the analgesic effect and its cholinergic and serotonergic mechanism of EA in the CIA rat model. To i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.014
更新日期：2005-09-28 00:00:00
abstract：:The present study describes the time course of recovery in the fast axonal transport of 3H-labeled proteins in the nerve and the electrophysiological parameters in the extensor muscle of rats after single subperineural injection of batrachotoxin (BTX) (9.3 x 10(-12) mol) into the peroneal nerve. The fast axonal transp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90322-x
更新日期：1981-11-23 00:00:00
abstract：:Previous work has demonstrated that 3 pharmacologically and neuroanatomically distinct analgesia systems can be sequentially activated by increasing numbers of transcutaneous tail-shock. To date, the categorization of the early (after 2 tail-shocks) and late (after 80-100 tail-shocks) analgesias as opiate-mediated has...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90310-6
更新日期：1992-06-05 00:00:00
abstract：:One model useful for demonstrating axonal regeneration in the central nervous system is that in which peripheral tissue, particularly the iris, is implanted into the brain or spinal cord. The aim of the present study was to establish the origin of some of the regenerating fibers by the use of an autoradiograhic tracin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91121-x
更新日期：1980-09-22 00:00:00
abstract：:The Fragile X mental retardation syndrome is the largest source of inherited mental retardation. The syndrome usually results from the transcriptional silencing of the fragile X mental retardation gene (FMR1). To date the most prominent reported neuronal abnormalities for the fragile X mental retardation syndrome incl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02363-1
更新日期：2003-05-02 00:00:00
abstract：:Insulin and the insulin-like growth factors (IGFs) may directly affect the growth, development, and maintenance of the vertebrate nervous system. Previous in vitro studies have focused on embryonic nervous tissue. In this study the effects of insulin, IGF-I, IGF-II and nerve growth factor (NGF) on regeneration and neu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91496-f
更新日期：1993-04-02 00:00:00
abstract：:An enriched environment has been shown to improve cognitive, behavioral and histopathological outcome after focal cerebral ischemia and head trauma. The purpose of this study was to determine the effect of an enriched environment on histopathology following global cerebral ischemia. Wistar rats (21 weeks of age) were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04089-1
更新日期：2003-02-21 00:00:00
abstract：:Nerve fibers and their axon terminals with substance P (SP)-like and calcitonin gene-related peptide (CGRP)-like immunoreactivity in the nucleus tractus solitarii were ultrastructurally characterized by a combination of immunofluorescent double staining and the PAP method. The axon terminals formed asymmetrical synapt...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90269-6
更新日期：1986-07-30 00:00:00
abstract：:The termination of a pathway recently discovered in monkey, from the external cuneate nucleus (ECN) to the thalamus, has been investigated with the degeneration method. A previous HRP study showed that the projection is crossed. The ECN fibers terminate a wedge-shaped zone located dorsally in the rostral half of the c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90856-8
更新日期：1981-11-16 00:00:00
abstract：:Insulin-like 6 immunoreactivity (irINSL6) was detected in Leydig cells of the mouse testis. In the brain, labeled somata were detected mainly in the caudal hypothalamus and midbrain. Double labeling the brainstem sections revealed that irINSL6 somata were 5-hydroxytryptamine (5-HT) positive. The presence of irINSL6 in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.077
更新日期：2005-04-08 00:00:00
abstract：:In sections of rat brain treated for Wisteria floribunda agglutinin (WFA) labelling the occurrence of parvalbumin (PARV)-, calbindin (CALB)- or choline acetyltransferase (ChAT) immunoreactivity was analyzed in the basal forebrain using dual-peroxidase and double-fluorescence methods. Only PARV-immunoreactive (-ir) neu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91205-7
更新日期：1993-12-17 00:00:00
abstract：:Recently, the kinetics of fast axonal transport of a single type of organelle, the serotonergic storage vesicle, was described in an identified axon of Aplysia using a pulsing technique combined with intracellular injection of [3H]serotonin. Here we extended the single axon studies by analyzing the movement of pulses ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91006-4
更新日期：1981-12-21 00:00:00
abstract：:The right wingbuds of stage 23-25 chick embryos were amputated at the future elbow region and a segment of 2-day neural tube was implanted longitudinally into the limb stump of experimental embryos to induce limb regeneration. Control embryos had no implant in the amputated limb stump. To analyze effects of the neural...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90196-8
更新日期：1985-04-01 00:00:00
