Abstract：
:Evidence is presented which suggests that central neural changes occur during the brief early phase after subcutaneous formalin injection that are essential for the expression of pain during the long-lasting (tonic) later phase. First, tonic pain responses to subcutaneous formalin injections are abolished only if the injected hindpaw is locally anesthetized at the time of injection as well as the time of testing (30-60 min later). Second, tonic formalin pain is substantially reduced by brief spinal anesthesia given 5 min before, but not 5 min after the formalin injection.
journal_name
Brain Resjournal_title
Brain researchauthors
Coderre TJ,Vaccarino AL,Melzack Rdoi
10.1016/0006-8993(90)91835-5subject
Has Abstractpub_date
1990-12-03 00:00:00pages
155-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)91835-5journal_volume
535pub_type
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