Abstract：
:Previous electrophysiological experiments have shown that brain noradrenaline neurons in the locus ceruleus are activated by thermal cutaneous stimuli. In the present study a putative involvement of excitatory amino acids (EAA) in cutaneous LC activation was analyzed. Intraventricular administration of kynurenic acid (1 mumol), a broad spectrum EAA antagonist, or the non-NMDA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 0.1 mumol) as well as subcutaneous administration of the specific NMDA antagonist MK 801 (2 mg/kg) almost totally abolished the response of LC neurons to both non-noxious and noxious cutaneous sensory stimuli. We propose that the activation of LC neurons following thermal cutaneous stimuli is mediated via release of EAA from nerve terminals emanating from nucleus paragigantocellularis (PGi).
journal_name
Brain Resjournal_title
Brain researchauthors
Hajós M,Engberg Gdoi
10.1016/0006-8993(90)91560-4subject
Has Abstractpub_date
1990-06-25 00:00:00pages
325-8issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(90)91560-4journal_volume
521pub_type
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