Cross-linking of NCAM receptors on neurons induces programmed cell death.

abstract：:The GABAB agonist, baclofen, causes a dose-dependent decrease in lordosis, and this effect is attenuated following hypothalamic serotonin, (5-HT) lesions. Baclofen administration is associated with decreased 5-HT activity in the medial preoptic (mPOA) and ventromedial nuclei and enhanced 5-HT activity in the midbrain ...

journal_title：Brain research

authors： Luine V,Cowell J,Frankfurt M

更新日期：1991-08-09 00:00:00

abstract：:Hypoxia-inducible transcription factors (HIFs) are crucially involved in brain development and cellular adaptation to hypoxia and ischemia. Degradation of HIF is regulated under normoxia by oxygen-dependent hydroxylation of specific prolyl residues on the labile alpha-subunit by HIF prolyl hydroxylases (PHD). Prolyl-4...

journal_title：Brain research

authors： Schneider C,Krischke G,Keller S,Walkinshaw G,Arend M,Rascher W,Gassmann M,Trollmann R

更新日期：2009-07-14 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) isolated from the brain and pituitary, has been shown to induce cell divisions in a variety of cell types. It also acts as a potent stimulator of angiogenesis, and it is important in the survival of several types of cultured neurons. Despite considerable information on the functio...

journal_title：Brain research

authors： Matsuda S,Desaki J,Okumura N,Shiosaka S,Imaoka S,Sakanaka M

更新日期：1992-04-10 00:00:00

abstract：:The radioligand [125I]alpha-bungarotoxin (alpha-BTX) has been used to test receptor binding to putative nicotinic cholinergic receptors in the hypothalamus. Using light microscopic autoradiography following third ventricular infusion of the radioligand we have previously demonstrated that in normally cycling rats and ...

journal_title：Brain research

authors： Miller MM,Silver J,Billiar RB

更新日期：1984-01-02 00:00:00

abstract：:Almost anyone who has ever lost weight can attest that it is harder to sustain weight loss than to lose weight. Maintenance of a 10% or greater reduced body weight is accompanied by decreases in energy expenditure to levels significantly below what is predicted solely on the basis of weight and body composition change...

journal_title：Brain research

authors： Rosenbaum M,Kissileff HR,Mayer LE,Hirsch J,Leibel RL

更新日期：2010-09-02 00:00:00

abstract：:Mouse embryonic stem (ES) cells were transplanted into the cochlea of adult guinea pigs in order to explore their survival, differentiation, and possible integration with the host tissue. With the purpose of investigating the possible effect of manipulating the local embryonic microenvironment, ES cells were transplan...

journal_title：Brain research

authors： Hu Z,Andäng M,Ni D,Ulfendahl M

更新日期：2005-07-27 00:00:00

abstract：:The pleiotropic cytokine tumor necrosis factor-alpha (TNFalpha) is implicated in the development of persistent pain through its actions in the periphery and in the central nervous system (CNS). Activation of the alpha(2)-adrenergic receptor is associated with modulation of pain, possibly through its autoregulatory eff...

journal_title：Brain research

authors： Covey WC,Ignatowski TA,Knight PR,Spengler RN

更新日期：2000-03-17 00:00:00

abstract：:The response of two populations of neurones in the substantia nigra (nigro-striatal compacta neurones and reticulata neurones) to microelectrophoretically administered putative neurotransmitters and stimulation of the ipsilateral striatum has been investigated in anaesthetized rats. There were marked differences betwe...

journal_title：Brain research

authors： Collingridge GL,Davies J

更新日期：1981-05-18 00:00:00

abstract：:A correlated intracellular and extracellular study of lumbar motoneuron excitability during sleep and wakefulness was performed in the chronic, unanesthetized, undrugged, normally respiring cat. Experiments were designed to reveal the extent to which hypotonia during active sleep in mammals is dependent on postsynapti...

journal_title：Brain research

authors： Morales F,Chase MH

更新日期：1981-11-30 00:00:00

abstract：:The effect of chronic ethanol administration on the fine structure of the hippocampal CA1 stratum oriens was examined in two lines of mice selectively bred for their differential sensitivity to acute ethanol exposure (long-sleep, LS and short-sleep, SS mice). Two experiments were performed. In the first experiment, mi...

journal_title：Brain research

authors： Scheetz AJ,Markham JA,Fifková E

更新日期：1987-04-21 00:00:00

abstract：:The retinohypothalamic tract (RHT) is a direct pathway from the retina to the suprachiasmatic nucleus (SCN). Electrical stimulation of the optic nerve or optic chiasm activates the RHT and produces shifts in phase of a circadian rhythm in SCN neuron activity in rat hypothalamic slices in vitro. The phase response curv...

journal_title：Brain research

authors： Shibata S,Moore RY

更新日期：1993-06-25 00:00:00

abstract：:Our previous study revealed that, during tonic muscle contraction, remarkable functional differences among intrinsic and extrinsic muscles were observed during two different grip movements, i.e., precision and power grips. To verify whether this evidence is true even under the phasic muscle contraction, magnetic stimu...

journal_title：Brain research

authors： Anson JG,Hasegawa Y,Kasai T,Latash ML,Yahagi S

更新日期：2002-05-03 00:00:00

abstract：:Fos expression in the globus pallidus (GP) of rats was elicited by the D2 agonist quinpirole both ipsilateral and contralateral to a unilateral nigrostriatal 6-hydroxydopamine (6-OHDA) injection; however, the 6-OHDA-treated hemisphere was more sensitive to this effect. The quinpirole-induced GP Fos expression was anta...

journal_title：Brain research

authors： Marshall JF,Cole BN,LaHoste GJ

更新日期：1993-12-31 00:00:00

abstract：:Traumatic brain injury (TBI) causes impairments of both motor and spatial memory performances. Research is only beginning to reveal the biochemical mechanism(s) underlying these deficits. It has been postulated that reactive oxygen species such as the superoxide and hydroxyl radicals, as well as the peroxynitrite anio...

journal_title：Brain research

authors： Long DA,Ghosh K,Moore AN,Dixon CE,Dash PK

更新日期：1996-04-22 00:00:00

abstract：:Biochemical analysis of the binding of [125I]Bolton-Hunter coupled substance P [( 125I]BH-SP) to slide-mounted sections of rat brain demonstrated that [125I]BH-SP labels a binding site with a structure-activity profile characteristic of a substance P receptor. Under optimized preincubation and incubation conditions, t...

journal_title：Brain research

authors： Rothman RB,Herkenham M,Pert CB,Liang T,Cascieri MA

更新日期：1984-08-20 00:00:00

abstract：:The urethrogenital (UG) reflex is a spinal sexual reflex which is tonically inhibited in the intact male rat by neurons in the nucleus paragigantocellularis (nPGi). The medial preoptic area of the hypothalamus (MPOA) is involved in the activation of male sexual behavior. The present study examines the effect of hypoth...

journal_title：Brain research

authors： Marson L,McKenna KE

更新日期：1994-02-28 00:00:00

abstract：:Nucleotide-repeat expansions underlie a heterogeneous group of neurodegenerative and neuromuscular disorders for which there are currently no effective therapies. Recently, it was discovered that such repetitive RNA motifs can support translation initiation in the absence of an AUG start codon across a wide variety of...

journal_title：Brain research

authors： Green KM,Linsalata AE,Todd PK

更新日期：2016-09-15 00:00:00

abstract：:The medial nucleus of the amygdala, bed nucleus of the stria terminalis, and medial preoptic area appear to mediate steroidal regulation of mating behavior in male rodents. The mechanism of action has not been determined. One way testosterone could enhance neuronal function is by increasing neurotransmitter levels, th...

journal_title：Brain research

authors： Swann JM,Newman SW

更新日期：1992-09-11 00:00:00

abstract：:While exercise is commonly recommended for PD patients to improve motor function, little is known about the disease-altering potential of exercise. Although others have demonstrated neuroprotective or neurorestorative effects of exercise in animal models of PD, the majority of these studies utilize young animals. In o...

journal_title：Brain research

authors： Hood RL,Liguore WA,Moore C,Pflibsen L,Meshul CK

更新日期：2016-09-01 00:00:00

abstract：:It has been well established that the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) opener, diazoxide, has protective effects on the heart and brain following ischemia/reperfusion injury. However, the mechanism of the neuroprotective effects of diazoxide remains unclear. This study highlights the anti-apo...

journal_title：Brain research

authors： Zhang H,Wang ZQ,Zhao DY,Zheng DM,Feng J,Song LC,Luo Y

更新日期：2011-01-25 00:00:00

abstract：:Evidence from a number of sources indicates that the major site of pro-opiomelanocortin (POMC)-producing cells in the CNS is the arcuate nucleus of the hypothalamus. Using immunocytochemical techniques, a second, smaller group of POMC cells has been detected in the nucleus tractus solitarius (NTS) area of the caudal m...

journal_title：Brain research

authors： Bronstein DM,Schafer MK,Watson SJ,Akil H

更新日期：1992-08-07 00:00:00

abstract：:Twice daily injections of 1.0 or 5.0 mg/kg D-amphetamine for 6 consecutive days differentially affected the response of dopaminergic neurons in the substantia nigra pars compacta to challenge injections of apomorphine on the following day. Thus, whereas treatment with the high amphetamine dose produced a dramatic shif...

journal_title：Brain research

authors： Kamata K,Rebec GV

更新日期：1984-10-29 00:00:00

abstract：:Activities of individual, force-sensitive mechanoreceptors (funnel canal organs) of the terminal segment (dactyl) of the crab leg have been recorded in freely moving animals. During the stance phase of walking receptors discharge in regular bursts that are closely correlated with activity of the opener muscle of the p...

journal_title：Brain research

authors： Zill SN,Libersat F,Clarac F

更新日期：1985-06-17 00:00:00

abstract：:The effects of the sulfated octapeptide of cholecystokinin (CCK8-S), the non-sulfated homolog (CCK8-NS) as well as the C-terminal di-, tri- and tetrapeptidic fragments (respectively CCK2, CCK3 and CCK4) were studied in vitro in rat hippocampal slices by extracellular recording of the spontaneous action potential disch...

journal_title：Brain research

authors： Böhme GA,Stutzmann JM,Blanchard JC

更新日期：1988-06-07 00:00:00

abstract：:We previously reported that glial fibrillary acidic protein (GFAP) levels increased significantly at 3 days after stab wounds, relative to sham-operated controls, reaching a maximum of 200% of control value at 5-7 days. They then fell to near-normal values by 21 days. To determine whether these protein changes correla...

journal_title：Brain research

authors： Hozumi I,Aquino DA,Norton WT

更新日期：1990-11-26 00:00:00

abstract：:Chronic administration of caffeine (s.c. for a period of 14 days in escalating doses of 10-70 mg/kg) increased the sensitivity of rat cerebral cortical neurons to the inhibitory action of microiontophoretically applied adenosine. The sensitivity of spontaneously firing rat cerebral cortical neurons in caffeine-treated...

journal_title：Brain research

authors： Lin Y,Phillis JW

更新日期：1990-06-18 00:00:00

abstract：:The ketogenic diet (KD) is a non-pharmacological treatment for specific types of epilepsy. In addition, it has been shown to be effective in mitigating other neurologic disorders. The KD is also effective in reducing body mass, leading to an increase in use by the general population for weight loss. As the popularity ...

journal_title：Brain research

authors： Miles KN,Skelton MR

更新日期：2020-05-01 00:00:00

abstract：:Pain resulting from peripheral nerve injury, characterised by ongoing pain, hyperalgesia and allodynia arises from peripheral and central processes. Here, we studied the potential role of central facilitations in nerve injury by investigating the effect of blocking the excitatory 5HT3 receptor with ondansetron. 5HT3 r...

journal_title：Brain research

authors： Suzuki R,Rahman W,Hunt SP,Dickenson AH

更新日期：2004-09-03 00:00:00

abstract：:The distribution of substance P (SP) immunoreactivity in the spinal nucleus of the rat trigeminal nerve and in the skin of the lower lip was examined following (a) unilateral electrolytic lesions of the trigeminal ganglion, (b) trigeminal rhizotomy, and (c) unilateral interruption of the mental nerve, the sensory bran...

journal_title：Brain research

authors： Cuello AC,Del Fiacco M,Paxinos G

更新日期：1978-09-08 00:00:00

abstract：:Stroke-prone spontaneously hypertensive rats (SHRSP) are a well-characterized, genetic model for stroke. We showed earlier that the structure and function of the tight junctions in SHRSP blood-brain barrier endothelial cells is disturbed prior to stroke. To investigate the molecular events leading to endothelial dysfu...

journal_title：Brain research

authors： Kirsch T,Wellner M,Luft FC,Haller H,Lippoldt A

更新日期：2001-08-10 00:00:00