Abstract：
:The effects of the sulfated octapeptide of cholecystokinin (CCK8-S), the non-sulfated homolog (CCK8-NS) as well as the C-terminal di-, tri- and tetrapeptidic fragments (respectively CCK2, CCK3 and CCK4) were studied in vitro in rat hippocampal slices by extracellular recording of the spontaneous action potential discharge frequency of neurons located in the CA1 stratum pyramidalis. Bath-applied CCK8-S concentration-dependently increased the action potential discharge frequency of hippocampal CA1-neurons in concentrations ranging from 0.05 to above 1 microM. Both CCK8-NS and CCK4 exhibited reversible and concentration-dependent excitatory effects. They were 4 and 10 times less potent than CCK8-S, respectively, as concentrations of 2 microM CCK8-NS and 5 microM CCK4 were needed to evoke the same excitation as that induced for a given neuron by 0.5 microM CCK8-S. In contrast, none of the shorter fragments (CCK2 and CCK3) were effective in altering spontaneous discharge of CCK8-S-sensitive neurons even at concentrations of 100 microM. The pharmacologic profile of the excitatory response observed in the rat hippocampus follows the same pattern as the binding profile observed on brain membrane preparations. It is therefore concluded that the CCK receptors involved in this response seem to be related more to the 'central'- or B-type CCK receptors rather than to the 'peripheral'- or A-type CCK receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Böhme GA,Stutzmann JM,Blanchard JCdoi
10.1016/0006-8993(88)90776-7subject
Has Abstractpub_date
1988-06-07 00:00:00pages
309-18issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(88)90776-7journal_volume
451pub_type
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