Abstract：
:Systemic administration of the protein synthesis inhibitor, cycloheximide, induced both phase advances and phase delays in the circadian rhythm of wheel-running activity in hamsters (Mesocricetus auratus) maintained in constant darkness or constant light. The magnitude and direction of the phase shifts were dependent on the circadian time (CT) of drug treatment. The phase response curves in constant darkness and constant light were of similar general shape, but they differed in the overall mean amplitude of the phase shifts. Maximal phase advances were observed after injections around CT 6-8, maximal delays at CT 0-2. Injections of various doses of cycloheximide at CT 0 induced a dose-dependent phase delay in the rhythm with a maximum delay induced by 10 mg cycloheximide. Injections of cycloheximide in animals with a split activity rhythm caused phase shifts of both components in the same direction (20/39) and in different directions (10/39). The results support the hypothesis that 80S ribosomal protein synthesis plays an important role in the biochemical mechanisms of circadian systems.
journal_name
Brain Resjournal_title
Brain researchauthors
Wollnik F,Turek FW,Majewski P,Takahashi JSdoi
10.1016/0006-8993(89)91053-6subject
Has Abstractpub_date
1989-09-04 00:00:00pages
82-8issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(89)91053-6journal_volume
496pub_type
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