Sex-related difference in substance P level in rat anterior pituitary: a model of neonatal imprinting by testosterone.

abstract：:Accumulating evidence indicates that extensive microglia activation-mediated local inflammation contributes to neuronal injury in cerebral ischemia. We have previously shown that 4-(2-butyl-6, 7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), a potent volume-regulated anion channel (VRAC) inhibitor, s...

journal_title：Brain research

authors： Han Q,Liu S,Li Z,Hu F,Zhang Q,Zhou M,Chen J,Lei T,Zhang H

更新日期：2014-01-13 00:00:00

abstract：:Neurotensin-producing perikarya and fibers have been identified in the ventral tegmental area of the rat, and recent microinjection studies indicate that neurotensin may function in the ventral tegmental area to regulate body temperature. In this study, the hypothermic response produced by intraventral tegmental injec...

journal_title：Brain research

authors： Kalivas PW,Nemeroff CB,Miller JS,Prange AJ Jr

更新日期：1985-02-11 00:00:00

abstract：:Short-latency afferent inhibition (SAI) and long-latency afferent inhibition (LAI) are well-known transcranial magnetic stimulation (TMS) paradigms used to probe the sensorimotor system. To date, there is a paucity of research examining the reliability of these neurophysiological measures. This information is required...

journal_title：Brain research

authors： Turco CV,Pesevski A,McNicholas PD,Beaulieu LD,Nelson AJ

更新日期：2019-11-15 00:00:00

abstract：:The development of spontaneous activity in response to morphine administration was studied at different postnatal ages in C57BL/6 mice. Morphine induced hyperactivity at all ages except in 3-week-old mice, in which a catatonic effect is evident. The results indicate that the neurophysiological and inhibitory systems r...

journal_title：Brain research

authors： Filibeck U,Castellano C,Oliverio A

更新日期：1981-11-01 00:00:00

abstract：:It has been hypothesised that the increased life span commonly observed in rodents that have had their diet restricted after weaning may be related to its effects on the anti-oxidant defence systems. However, undernutrition during the gestation and pre-weaning period is known to have long-term deleterious effects on a...

journal_title：Brain research

authors： Partadiredja G,Worrall S,Simpson R,Bedi KS

更新日期：2008-07-30 00:00:00

abstract：:The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...

journal_title：Brain research

authors： Anezaki T,Yanagisawa K,Takahashi H,Nakajima T,Miyashita K,Ishikawa A,Ikuta F,Miyatake T

更新日期：1992-03-06 00:00:00

abstract：:We have investigated the role of NMDA receptors in the rat dorsal horn in mediating neuronal responses to noxious hindlimb ischemia, induced by acute occlusion of the femoral artery, as well as in the hyperalgesia evident when noxious mechanical stimuli were applied to the ischemic limb. Two specific NMDA antagonists,...

journal_title：Brain research

authors： Sher GD,Mitchell D

更新日期：1990-07-02 00:00:00

abstract：:The cerebellum and inferior olive of adult homozygous leaner mutant mice (tgIa/tgIa) were examined using anti-vitamin D-dependent calcium binding protein immunohistochemistry, and Nissl staining. The immunohistochemical staining revealed that cerebellar Purkinje cell loss in leaner is restricted to alternating saggita...

journal_title：Brain research

authors： Heckroth JA,Abbott LC

更新日期：1994-09-26 00:00:00

abstract：:DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] is a potent neurotoxicant in both vertebrate and invertebrate species. We have previously reported that neonatal exposure to DDT affects the muscarinic cholinergic receptors (MAChR) in the cerebral cortex in the neonatal mouse, leading to permanent disturbances in th...

journal_title：Brain research

authors： Eriksson P,Ahlbom J,Fredriksson A

更新日期：1992-06-12 00:00:00

abstract：:The extrafusal and intrafusal muscle fibers in the masseter muscle are innervated by motoneurons in the trigeminal motor nucleus (Mo 5). In the present study, we found that the number of trigeminal motor neurons in the male mouse was significantly larger than that in the female. However, we could not detect any signif...

journal_title：Brain research

authors： Maeda N,Sugiyama H,Suemune S,Wakisaka H,Niida S,Ogata K,Miyata K

更新日期：1993-11-05 00:00:00

abstract：:Activation of neuronal nicotinic acetylcholine receptors (nAChRs) modulates the induction of long-term potentiation (LTP), a possible cellular mechanism for learning. This study was undertaken to determine the effects of activation of nAChRs by nicotine on long-term plasticity in the songbird zebra finch, which is a v...

journal_title：Brain research

authors： Salgado-Commissariat D,Rosenfield DB,Helekar SA

更新日期：2004-08-20 00:00:00

abstract：:Hippocampal neurogenesis plays a very important role in learning and memory functions. In a search for best neurological drugs that protect neuronal cells and stimulate neurogenesis with no side effects, cannabinoids proved to be a strong group of substances having many beneficial properties. The aim of this study was...

journal_title：Brain research

authors： Andres-Mach M,Haratym-Maj A,Zagaja M,Rola R,Maj M,Chrościńska-Krawczyk M,Luszczki JJ

更新日期：2015-10-22 00:00:00

abstract：:Exposure to toxicants prenatally and postnatally could have deleterious consequences on the offspring. Postnatal exposure to valproate in mice pups is capable of inducing experimental autism resulting in neurobehavioral aberrations. Consumption of green tea has been associated with neuronal protection against the impa...

journal_title：Brain research

authors： Banji D,Banji OJ,Abbagoni S,Hayath MS,Kambam S,Chiluka VL

更新日期：2011-09-02 00:00:00

abstract：:Gabapentin, a drug useful in several neurological and psychiatric disorders, decreased K(+) (15 mM)-induced [Ca(2+)](i) increase in Fura-PE3-loaded rat neocortical synaptosomes (IC(50)=9.7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response ...

journal_title：Brain research

authors： Meder WP,Dooley DJ

更新日期：2000-09-01 00:00:00

abstract：:Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and m...

journal_title：Brain research

authors： Li S,Chen X,Mao L,Zahid KR,Wen J,Zhang L,Zhang M,Duan J,Duan J,Yin X,Wang Y,Zhao L,Tang X,Wang X,Xu G

更新日期：2018-08-01 00:00:00

abstract：:Retinal ganglion cells were labeled with horseradish peroxidase injected into the superior colliculus of normal pigmented rats. It is shown that virtually all ganglion cells with crossed axons project to the tectum, thus including all cell types described so far in the rat. The results contrast with the conclusion tha...

journal_title：Brain research

authors： Linden R,Perry VH

更新日期：1983-08-01 00:00:00

abstract：:Basal limbic structures (insula, amygdala, hippocampus and surrounding areas) were explored for unit responses to vagal volleys in awake, sitting, squirrel monkeys. Triple shocks were applied every 4 sec to the left cervical vagus nerve. As a control for adventitious activation by extravagal somatic afferents, units r...

journal_title：Brain research

authors： Radna RJ,MacLean PD

更新日期：1981-05-25 00:00:00

abstract：:Putative N-type voltage-sensitive calcium channels were localized autoradiographically in thaw-mounted rat brain slices using [125I]omega-conotoxin GVIA as a ligand. Density of the toxin binding sites were highly heterogeneous throughout the brain. The highest density of the binding sites was observed in the glomerula...

journal_title：Brain research

authors： Takemura M,Kiyama H,Fukui H,Tohyama M,Wada H

更新日期：1988-06-07 00:00:00

abstract：:Ethylcholine aziridinium ion (AF64A) diluted in artificial perilymph, or artificial perilymph alone was infused into the cochlea of chinchillas. After a survival time of 7 days, the cochleas were fixed with aldehydes, post-fixed in osmium and embedded in epoxy resin for light and electron microscopy. The ultrastructur...

journal_title：Brain research

authors： Morley BJ,Spangler KM,Schneider BL,Javel E

更新日期：1991-03-22 00:00:00

abstract：:As measured by extracellular single-cell recording, the responses to adenosine triphosphate (ATP) by ATP-sensitive chemoreceptors (ATP cells) on the olfactory organ of the spiny lobster are markedly suppressed by adenosine diphosphate (ADP), adenosine monophosphate (AMP) and to a lesser extent, adenosine, when each is...

journal_title：Brain research

authors： Gleeson RA,Carr WE,Trapido-Rosenthal HG

更新日期：1989-09-11 00:00:00

abstract：:Variations in cerebral blood flow and partial pressures of oxygen and carbon dioxide (pO2, pCO2) were studied in rabbits during short-duration (1 min) immobilization stress. The techniques used enabled us to determine these variables locally in the caudate nucleus in a continuous, simultaneous and quantitative fashion...

journal_title：Brain research

authors： Pinard E,Lacombe P,Reynier-Rebuffel AM,Seylaz J

更新日期：1985-08-12 00:00:00

abstract：:The endocrine disruptor Bisphenol-A (BPA) has been shown to modulate estrogenic, androgenic, and anti-androgenic effects. The effects of BPA exposure during early organizational periods of development have been well documented. The current study focuses on the effects of short term, low-dose BPA exposure on anxiety, s...

journal_title：Brain research

authors： Diaz Weinstein S,Villafane JJ,Juliano N,Bowman RE

更新日期：2013-09-05 00:00:00

abstract：:Sex steroid hormones regulate various neural functions that control vertebrate sociosexual behavior. A number of sex steroids can be synthesized de novo in the brain, including estrogens by the enzyme aromatase. Aromatase, the neuropeptides arginine vasotocin/vasopressin, and the monoamine neurotransmitter dopamine ha...

journal_title：Brain research

authors： Marsh KE,Creutz LM,Hawkins MB,Godwin J

更新日期：2006-12-18 00:00:00

abstract：:We previously described a rat model where the injection of formalin in the tail induced a facilitation of the hindpaw withdrawal reflexes (hyperalgesia). In the present work, after injecting formalin in the tail, we measured the levels of pro-nociceptive mediators tumor necrosis factor-alpha (TNF) and substance P (SP)...

journal_title：Brain research

authors： Bianchi M,Martucci C,Biella G,Ferrario P,Sacerdote P

更新日期：2004-09-03 00:00:00

abstract：:The localization of the methionine-enkephalin-Arg6-Gly7-Leu8 (Met-Enk-Arg-Gly-Leu)-like immunoreactivity-containing neurons in the rat lumbosacral spinal cord was immunohistochemically examined by an antiserum very specific to Met-Enk-Arg-Gly-Leu. The immunoreactive neurons occupied the positions corresponding to the ...

journal_title：Brain research

authors： Shimosegawa T,Koizumi M,Toyota T,Goto Y,Yanaihara C,Yanaihara N

更新日期：1987-03-17 00:00:00

abstract：:Stereotaxically placed intracerebral microinjections of 6-hydroxydopamine (6-OHDA) were used to produce selective and extensive lesions of either the dopaminergic nigro-neostriatal bundle or the dorsal and ventral noradrenergic projections in the rat. The extensive damage of the noradrenergic pathways which is typical...

journal_title：Brain research

authors： Roberts DC,Zis AP,Fibiger HC

更新日期：1975-08-15 00:00:00

abstract：:The duration of the sensitive period of the kitten visual cortex to the effects of monocular deprivation was explored by studies of the behavioral and physiological recovery from extended periods of monocular occlusion imposed from birth, and by examination of the physiological effects of a 3 month period of monocular...

journal_title：Brain research

authors： Cynader M,Timney BN,Mitchell DE

更新日期：1980-06-09 00:00:00

abstract：:The brain cholinergic system may undergo structural and functional alterations both in human epilepsy and in respective animal models, but the causal relationships between these alterations and epilepsy remain to be established. In this study, we attempted to examine how the inhibition of epilepsy-related cholinergic ...

journal_title：Brain research

authors： Soares JI,Da Costa C,Ferreira MH,Andrade PA,Maia GH,Lukoyanov NV

更新日期：2019-08-15 00:00:00

abstract：:The effect of lowered brain glutathione content on the glutamate release following cerebral ischemia was investigated. Diethylmaleate (4 mmol/kg, i.p.), a commonly used chemical reagent for tissue glutathione depletion, significantly reduced the ischemia-induced glutamate release. The release of another excitatory ami...

journal_title：Brain research

authors： Yang CS,Lin NN,Liu L,Tsai PJ,Kuo JS

更新日期：1995-11-06 00:00:00

abstract：:Aromatization of testosterone in the preoptic area of the male ring dove is required for the expression of specific estrogen-sensitive sexual behavior. Estradiol metabolism and/or binding of the aromatization product(s) to the preoptic estrogen receptors (ER) could interfere with the apparent increase in estradiol for...

journal_title：Brain research

authors： Steimer T,Hutchison JB

更新日期：1989-02-20 00:00:00