Abstract：
:Variations in cerebral blood flow and partial pressures of oxygen and carbon dioxide (pO2, pCO2) were studied in rabbits during short-duration (1 min) immobilization stress. The techniques used enabled us to determine these variables locally in the caudate nucleus in a continuous, simultaneous and quantitative fashion. It could be shown that cerebral blood flow and arterial blood pressure increased in parallel immediately after inducing the stress reaction, and that pO2 increased further, indicating that cerebral oxygen supply is maintained by the hyperaemia. Previous administration of a beta-receptor blocker or of a cholinergic receptor blocker significantly diminished the cerebrovascular reaction to stress, inducing a decrease in pO2 during the reaction. Administration of both blockers nearly abolished the cerebral vasodilation studied. Previous administration of an alpha-receptor blocker enhanced the reactive hyperaemia. No disturbance of the blood-brain barrier could be observed in rabbits subjected to stress. Intravenous injection of adrenaline, as well as angiotensin II inducing similar increases in blood pressure, had no comparable effect on the blood flow. The conclusion is that in this model of anxiety, neurogenic mechanisms are involved in the provision of a sufficient oxygen supply to the brain.
journal_name
Brain Resjournal_title
Brain researchauthors
Pinard E,Lacombe P,Reynier-Rebuffel AM,Seylaz Jdoi
10.1016/0006-8993(85)90927-8subject
Has Abstractpub_date
1985-08-12 00:00:00pages
305-14issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(85)90927-8journal_volume
340pub_type
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