Abstract：
:The suprachiasmatic nucleus (SCN) and the pineal body in 3 types of inherited hormone-deficient mice, the dw, lit and hyt mice were examined by morphological, morphometric and biochemical techniques. In the dw and lit mice the SCN was underdeveloped. In the ventral part of the SCN, where most of the retinal fibers appeared to terminate, both cell number and cell size were decreased, although the size of the SCN was unaltered. In addition, the pineal bodies of both mice were morphologically underdeveloped and showed low levels of N-acetyltransferase activity. In contrast, the hyt SCN was comparable to the normal controls in every respect. The hyt pineal was well developed and showed levels of enzyme activity comparable to the controls. However, in all the deficient mice, the optic nerve appeared to be normal in morphological and biochemical studies. These results suggest that the underdevelopment of the pineal body, the reduced levels of spontaneous locomotion and the indistinct diurnal periodicity of the dw and lit mice might be related to the retarded neuronal growth of the SCN, and that growth hormone likely is indispensable for the development of the SCN.
journal_name
Brain Resjournal_title
Brain researchauthors
Noguchi T,Sugisaki T,Kudo M,Satoh Idoi
10.1016/0165-3806(86)90279-8subject
Has Abstractpub_date
1986-05-01 00:00:00pages
161-72issue
2eissn
0006-8993issn
1872-6240journal_volume
391pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:When rat striatal membranes, photolabeled with [3H]dopamine under assay conditions similar to those used for dopamine-sensitive adenylate cyclase, were subjected to sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis, several radioactively labeled bands appeared. Labeling of these bands was reduced in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90426-1
更新日期：1981-12-28 00:00:00
abstract：:MPTP is a neurotoxin thought to damage dopaminergic neurons through free radical formation. MPTP is metabolized in the brain to MPP(+), which is taken up into dopaminergic neurons via the dopamine transporter and assumed to impair mitochondrial function. We used striatal synaptosomes and telencephalic mitochondria to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02675-1
更新日期：2003-06-13 00:00:00
abstract：:Nitric oxide (NO) has been proposed as an intercellular messenger mediating postsynaptic to presynaptic information transfer in the induction of long-term potentiation. A number of studies support the possible involvement of NO in synaptic plasticity. NO may have a role in synaptogenesis and synaptic plasticity in dev...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01161-5
更新日期：1999-01-23 00:00:00
abstract：:We compared the relative abilities of a series of calmodulin inhibitors and protein kinase C inhibitors to influence 45Ca2+ influx through voltage-dependent Ca2+ channels in PC12, a clonal neural cell line. K+-depolarization-dependent 45Ca2+ uptake was reduced by the calmodulin inhibitors calmidazolium, trifluoperazin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91403-x
更新日期：1987-02-24 00:00:00
abstract：:Suction lesions of the right frontal cerebral cortex in rats induce a period of spontaneous hyperactivity. The hyperactivity, as measured by an increase in running wheel activity begins about one week post-operatively and continues throughout the remainder of a 30-day observation period. The increased activity is acco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91303-2
更新日期：1981-08-10 00:00:00
abstract：:The effects of chronic treatment of rats with RWJ 37796, a novel aryl-piperazine containing antipsychotic drug, on brain monoamine receptors were studied. Rats were treated daily with RWJ 37796 (1.3 mg/kg), the typical antipsychotic haloperidol (1 mg/kg) or vehicle (control) for 21 days, and were sacrificed 3 days aft...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00155-j
更新日期：1995-04-24 00:00:00
abstract：:The cytokine interleukin-12 (IL-12) is mainly produced in response to bacterial or parasitic infections. We examined the capacity of mouse brain microglia to release IL-12 forms upon challenge with bacterial lipopolysaccharide (LPS) and studied its modulation by sympathomimetics. LPS evoked the release of IL-12p40 whe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02174-6
更新日期：2001-04-27 00:00:00
abstract：:The nitric oxide (NO) metabolome and the NO metabolite-based neurovascular protective pathways are dysregulated after stroke. The major NO metabolite S-nitrosoglutahione (GSNO) is essential for S-nitrosylation-based signaling events and the inhibition of S-nitrosoglutahione (GSNO)-metabolizing enzyme GSNO reductase (G...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146879
更新日期：2020-08-15 00:00:00
abstract：:Multiple-unit activity (MUA) in the agranular medial prefrontal cortex (PFC) was recorded in conscious rabbits during a classical conditioning procedure involving repeated pairings of a 4-s tone conditioned stimulus (CS) with eye shock. Prior to behavioral training, significant tone-evoked increases in prefrontal MUA ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91435-7
更新日期：1988-02-23 00:00:00
abstract：:A hundred years after Lhx2 ortholog apterous was identified as a critical regulator of wing development in Drosophila, LIM-HD gene family members have proved to be versatile and powerful components of the molecular machinery that executes the blueprint of embryogenesis across vertebrate and invertebrate species. Here,...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.02.046
更新日期：2019-02-15 00:00:00
abstract：:The possibility that the motor cortex receives peripheral input directly from the thalamus was examined using the evoked potential method and the following results were obtained. Potentials in the motor cortex evoked by stimulation of superficial radial (SR) or group II deep radial (DR) nerve were neither abolished no...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90532-8
更新日期：1979-08-24 00:00:00
abstract：:The neurobiology of autism spectrum disorders (ASDs) has become increasingly understood since the advent of magnetic resonance imaging (MRI). Initial observations of an above-average head circumference were supported by structural MRI studies that found evidence of increased total brain volume and early rapid brain ov...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2010.11.076
更新日期：2011-03-22 00:00:00
abstract：:The telencephalon of teleost fish shows high affinity uptake for D-[3H]aspartate, intermediate levels of GABAergic markers and low levels of cholinergic enzymes. Experimental results (resection of the olfactory tracts or unilateral kainic acid administration in the telencephalon) suggest that: the projection from the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90823-6
更新日期：1985-10-07 00:00:00
abstract：:A study of seizure activity and neuronal cell death produced by intracerebroventricular kainic acid had suggested that seizures conveyed by the hippocampal mossy fibers are more damaging to CA3 pyramidal cells than seizures conveyed by other pathways. To test this idea, the effects of a unilateral mossy fiber lesion w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91171-c
更新日期：1990-03-26 00:00:00
abstract：:Intracerebroventricular (ICV) streptozotocin (STZ) treated rat has been described as a suitable model for sporadic Alzheimer's disease (AD). Central application of STZ has demonstrated behavioral and neurochemical features that resembled those found in human AD. Chronic treatments with antioxidants, acetylcholinestera...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.09.056
更新日期：2011-12-02 00:00:00
abstract：:The hippocampal formation is a highly plastic brain region that is sensitive to stress. It receives extensive noradrenergic projections, and noradrenaline is released in the hippocampus in response to stressor exposure. The hippocampus expresses particularly high levels of the alpha(1D) adrenergic receptor (ADR) and w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.084
更新日期：2010-04-06 00:00:00
abstract：:The D stereoisomer of dihydroxyphenylalanine (D-DOPA) and its alpha-keto acid metabolite 3,4-dihydroxyphenylpyruvic acid (DHPPA) when infused into the striatum, significantly increased in vivo extracellular dopamine levels. Following D-DOPA administration, the cumulative increase in dopamine levels was 30% of the incr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00116-3
更新日期：1996-04-29 00:00:00
abstract：:Unilateral injections of 6-hydroxydopamine into the substantia nigra in the rat significantly attenuated cortical spreading depression (CSD)-induced eating from the hemisphere ipsilateral but not contralateral to the lesion. The lateralized decrease in elicited feeding was correlated with postlesion body weight loss, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90428-1
更新日期：1979-01-12 00:00:00
abstract：:Rat hippocampal minces were loaded with [acetyl 1-14C]acetylcholine ([14C]ACh) in the presence of the "poorly penetrating" acetylcholinesterase (EC 3.1.1.7; AChE) inhibitor echothiophate and the effect of high K+ depolarization determined on the subcellular storage and release of [14C]ACh and its metabolites. Results ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00078-9
更新日期：1996-06-24 00:00:00
abstract：:The effect of somatostatin on muscarinic receptors (mAchR) was investigated through saturation experiments of [3H]oxotremorine-M-acetate and oxotremorine/[3H]N-methyl-scopolamine competition experiments. Somatostatin converted oxotremorine high affinity binding sites to low affinity sites in the hippocampus and cerebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90879-6
更新日期：1986-07-09 00:00:00
abstract：:Subcutaneous administration of rotenone has recently attracted attention because of its convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in animal models. However, the wide range of doses reported in the literature makes it difficult to evaluate the effectiveness of this techniq...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.11.020
更新日期：2017-01-15 00:00:00
abstract：:In anesthetized cats, medial gastrocnemius motor units (MUs) were electrically stimulated via their ventral-root axons with independent random patterns. Muscle tension and homonymous alpha-motoneuron (alpha-MN) membrane potential fluctuations in response to these stimuli were recorded simultaneously. Cross-correlating...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90763-2
更新日期：1985-09-23 00:00:00
abstract：:Characteristics of neural corticosteroid receptors were studied in 51 adrenally-intact macaque monkeys using a modification of a corticosteroid receptor assay developed in this laboratory for rodent studies. Using cortisol as a ligand, two receptor subtypes could be distinguished and with similar Kd's to those observe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91249-1
更新日期：1994-02-21 00:00:00
abstract：:Neurotransmitter effects were studied on in vitro release of immunoreactive somatostatin (SRIF) from slices prepared from several regions of the rat brain: mediobasal hypothalamus (MBH), preoptic anterior hypothalamic area (POA) and amygdaloid complex (AMY). Potassium (K+, 56 mM) stimulated SRIF release in all structu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90523-0
更新日期：1981-06-29 00:00:00
abstract：:Repeated electrode penetration of the dentate and interpositus nuclei in a rhesus monkey transformed an 11-13 Hz physiologic tremor into a much larger action tremor at 5-7 Hz. This tremor was associated with muscle spindle spike train modulation and reflexly evoked tremor modulation of interpositus and motor cortex ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90308-1
更新日期：1984-12-10 00:00:00
abstract：:The anatomical structure of the basal ganglia indicates that the input from the cerebral cortex is funnelled through the striatum to the globus pallidus and substantia nigra. This structure implies integration of the information as it is transferred through the basal ganglia. In order to investigate this integration, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90363-4
更新日期：1985-11-25 00:00:00
abstract：:Lesions of the anterior hypothalamus-medial preoptic area (AH-MPOA) impair courtship and copulatory behavior in male Cnemidophorus inornatus, a sexually reproducing species of whiptail lizard, and male-like pseudosexual behaviors in C. uniparens, an all-female species. These results suggest that, since C. inornatus is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90046-9
更新日期：1994-04-18 00:00:00
abstract：:Alpha-bungarotoxin binding sites in chick retina from 12 days in ovo to hatching, were visualized at the ultrastructural level by use of a 1:1 conjugate of horseradish peroxidase with alpha-bungarotoxin. At all stages binding sites in the inner plexiform layer were localized in synapses, predominantly on or near the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90774-x
更新日期：1980-11-10 00:00:00
abstract：:Rat central nervous system (CNS) tissue sections were immunostained by the peroxidase-anti-peroxidase (PAP) method using a rabbit serum directed against rat liver 5'-nucleotidase. In paraffin sections from the brains of 60-day-old rats 5'-nucleotidase immunoreactivity occurred in the same white-matter regions as myeli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90090-2
更新日期：1985-05-01 00:00:00
abstract：:Ouabain (5 X 10(-4) M) induced a 6-fold increase in intracellular Na+ and a 65% loss of cellular K+ in C6 glial cells which was accompanied by a 12 mV decrease in the resting membrane potential. Following ouabain washout intracellular ion concentrations and the membrane potential returned to control levels suggesting...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90649-1
更新日期：1976-03-05 00:00:00
