Retrograde labeling of neurons in spinal cord that project directly to nucleus accumbens or the septal nuclei in the rat.

abstract：:An isoindolin-1-one derivate, JM-1232(-), was recently developed as a sedative and hypnotic agent with a strong affinity for the central benzodiazepine binding site of gamma-aminobutyric acid(A) (GABA(A)) receptors. The purpose of this study was to examine the effects of JM-1232(-) on the cardiovascular and sympatheti...

journal_title：Brain research

authors： Shirasaka T,Kunitake T,Tsuneyoshi I

更新日期：2009-12-01 00:00:00

abstract：:MPTP is a neurotoxin thought to damage dopaminergic neurons through free radical formation. MPTP is metabolized in the brain to MPP(+), which is taken up into dopaminergic neurons via the dopamine transporter and assumed to impair mitochondrial function. We used striatal synaptosomes and telencephalic mitochondria to ...

journal_title：Brain research

authors： Fonck C,Baudry M

更新日期：2003-06-13 00:00:00

abstract：:Neurons containing immunoreactivity to the endogenous lactose-binding lectin, RL-29, were examined in the L4 segment of the spinal cord of rats with an experimental neuropathy. The cells appeared by 5 days and were also present at 14 and 28 days postoperatively. All neurons were found in the dorsal horn ipsilateral to...

journal_title：Brain research

authors： Cameron AA,Dougherty PM,Garrison CJ,Willis WD,Carlton SM

更新日期：1993-08-20 00:00:00

abstract：:During a simple reaction time task using auditory or visual stimuli, a total of 96 single units were recorded from the dorsolateral prefrontal cortex of macaque monkeys. These monkeys were trained to depress a lever for a fixed period which produced a tone burst or a small spot of light. After a variable period, the s...

journal_title：Brain research

authors： Ito SI

更新日期：1982-09-09 00:00:00

abstract：:Intracellular free calcium concentration ([Ca2+]i) was measured in cultured explants of myenteric plexus neurones by using the fluorescent calcium indicator Indol in combination with patch-clamp techniques. The basal [Ca2+]i was 94 nM and spontaneous oscillations in the internal free calcium concentration were recorde...

journal_title：Brain research

authors： Trouslard J,Mirsky R,Jessen KR,Burnstock G,Brown DA

更新日期：1993-10-08 00:00:00

abstract：:Astrocytes and microglia in the spinal cord have recently been reported to contribute to the development of peripheral inflammation-induced exaggerated pain states. Both lowering of thermal pain threshold (thermal hyperalgesia) and lowering of response threshold to light tactile stimuli (mechanical allodynia) have bee...

journal_title：Brain research

authors： Milligan ED,Mehmert KK,Hinde JL,Harvey LO,Martin D,Tracey KJ,Maier SF,Watkins LR

更新日期：2000-04-07 00:00:00

abstract：:The present study was undertaken to confirm the dorsolateral pontomesencephalic reticular formation (an area that includes the nucleus cuneiformis (NCF) and nucleus parabrachialis (NPB)) as a sensitive site for stimulation-produced antinociception and to investigate the possibility that there are cells in this region ...

journal_title：Brain research

authors： Haws CM,Williamson AM,Fields HL

更新日期：1989-04-03 00:00:00

abstract：:Acute estradiol (E2) can potentiate the excitatory responses of hypothalamic ventromedial nucleus (VMN) neurons to neurotransmitters. To investigate the mechanism(s) underlying the potentiation, the whole-cell patch voltage clamp technique was used to study VMN neurons in hypothalamic slices prepared from female juven...

journal_title：Brain research

authors： Kow LM,Devidze N,Pataky S,Shibuya I,Pfaff DW

更新日期：2006-10-20 00:00:00

abstract：:Physical exercise is likely to alter brain function and to afford neuroprotection in several neurological diseases. Although the favorable effects of physical exercise on traumatic brain injury (TBI) patients is well known, little information is available regarding the role of free radicals in the improvement induced ...

journal_title：Brain research

authors： Lima FD,Oliveira MS,Furian AF,Souza MA,Rambo LM,Ribeiro LR,Silva LF,Retamoso LT,Hoffmann MS,Magni DV,Pereira L,Fighera MR,Mello CF,Royes LF

更新日期：2009-07-07 00:00:00

abstract：:Recently mutations in ubiquilin-2 were identified in patients with amyotrophic lateral sclerosis (ALS) and ALS/dementia providing direct evidence for the importance of this protein in neurodegenerative diseases. Histological studies have suggested that ubiquilin-1/-2 are associated with various pathological inclusions...

journal_title：Brain research

authors： Rutherford NJ,Lewis J,Clippinger AK,Thomas MA,Adamson J,Cruz PE,Cannon A,Xu G,Golde TE,Shaw G,Borchelt DR,Giasson BI

更新日期：2013-08-02 00:00:00

abstract：:The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion. In comparison with the control group, indomethacin sig...

journal_title：Brain research

authors： Phillis JW,Smith-Barbour M,Perkins LM,O'Regan MH

更新日期：1994-08-01 00:00:00

abstract：:The short and long-term effects of systemic administration of kainic acid to immature animals were studied in rats. Kainic acid was administered systemically to rats of 1-30 days of age. The rats were monitored for both behavioral and EEG changes. To study the effects of kainic acid on seizure susceptibility, status e...

journal_title：Brain research

authors： Holmes GL,Thompson JL

更新日期：1988-03-01 00:00:00

abstract：:Ion-selective microelectrode techniques were used to study extracellular K+ changes associated with penicillin-induced epileptogenesis in the CA3 region of hippocampal slices. Recordings were made in slices taken from rats 9-16 days of age, which have a pronounced capacity to undergo prolonged synchronized afterdischa...

journal_title：Brain research

authors： Swann JW,Smith KL,Brady RJ

更新日期：1986-12-01 00:00:00

abstract：:Considerable disagreement exists concerning the degree to which sparing and/or recovery of function occurs following CNS damage at birth rather than in adulthood. To study this question, the spinal cord was hemisected in neonatal and adult cats and the motor behavior of the two groups was compared when the neonatal op...

journal_title：Brain research

authors： Bregman BS,Goldberger ME

更新日期：1983-08-01 00:00:00

abstract：:Because the occurrence of rapid eye movement (REM) sleep is critically dependent upon an animal's thermal balance, acute pharmacological treatments may effect REM sleep through effects on thermoregulation. We describe how manipulating ambient temperature (T(a)) alters the REM sleep-suppressing effects of systemically-...

journal_title：Brain research

authors： Szymusiak R,Danowski J,McGinty D

更新日期：1994-02-04 00:00:00

abstract：:In the dorsal horn of barbiturate-anaesthetized cats evidence was obtained for a different distribution of enkephalin-preferring and morphine-preferring receptors. When ejected electrophoretically from micropipettes, morphine reduced the nociceptive responses of neurones of laminae IV and V when administered in the su...

journal_title：Brain research

authors： Duggan AW,Johnson SM,Morton CR

更新日期：1981-12-21 00:00:00

abstract：:Wayfinding is a complex cognitive function involving different types of information, such as knowledge about landmarks and direction information. This variety of processes suggest that multiple neural mechanisms are involved, e.g., the hippocampal system, the posterior parietal and temporal cortical areas. Although pa...

journal_title：Brain research

authors： van Asselen M,Kessels RP,Kappelle LJ,Neggers SF,Frijns CJ,Postma A

更新日期：2006-01-05 00:00:00

abstract：:Attachment, growth and morphological differentiation of isolated adult rat oligodendrocytes cultured on a naturally produced basement membrane-like extracellular matrix (ECM) occurred much faster than on poly-L-lysine (PLL) coated tissue culture dishes. In each individual trial the cells cultured on ECM exhibited, wit...

journal_title：Brain research

authors： Lubetzki-Korn I,Ovadia H,Vlodavsky I,Fuks Z,Abramsky O

更新日期：1983-05-09 00:00:00

abstract：:10-fold higher doses in SW mice. Furthermore, cotreatment of 129/SvEv mice with morphine plus a low dose of naltrexone (ca. 0.1 microgram/kg) that markedly enhances and prolongs morphine's antinociceptive effects in SW mice did not enhance, and often attenuated6 h. The marked GM1-induced attenuation of morphine's anti...

journal_title：Brain research

authors： Crain SM,Shen K

更新日期：2000-02-21 00:00:00

abstract：:In an effort to further characterize the proteins of the auditory nerve, the effects of hair cell loss on rapidly transported proteins of the auditory nerve were studied. The effects were studied in the waltzing guinea pig, a genetically deaf animal which displays an age-dependent loss of sensory cells, and in normal ...

journal_title：Brain research

authors： Wenthold RJ,McGarvey ML

更新日期：1982-12-16 00:00:00

abstract：:The aim of this study was to assess the effect of Alzheimer's disease has on the functional integrity of several signal transduction proteins. The relative levels of the G-protein alpha subunits Gs alpha-L, Gs alpha-S, Gi alpha-2 and G(o) alpha were measured by western blotting and found to be unchanged in membranes p...

journal_title：Brain research

authors： Ross BM,McLaughlin M,Roberts M,Milligan G,McCulloch J,Knowler JT

更新日期：1993-09-17 00:00:00

abstract：:The lipid, protein, acetylcholine and ATP content of cholinergic synaptic vesicles isolated from the richly innervated electric organ of Torpedo marmorata and purified to constant composition has been determined. The number of vesicles present in the preparations has been estimated by quantitative electron microscopy ...

journal_title：Brain research

authors： Ohsawa K,Dowe GH,Morris SJ,Whittaker VP

更新日期：1979-02-09 00:00:00

abstract：:We investigated the influence of muramyl dipeptide (MDP), a cell wall component of Gram-positive bacteria, on cytokine-induced nitric oxide (NO) production in rat primary astrocytes. MDP alone did not induce NO release in astrocyte cultures. However, MDP increased astrocyte NO production and subsequent nitrite accumul...

journal_title：Brain research

authors： Trajkovic V,Samardzic T,Stosic-Grujicic S,Ramic Z,Mostarica Stojkovic M

更新日期：2000-11-10 00:00:00

abstract：:We recently reported raphe neurones which frequently fired spikes in short bursts. However, the action potentials were broad and the neurones fired in a slow and regular pattern, suggesting they were an unusual type of 5-hydroxytryptamine (5-HT) neurone. In the present study, we investigated whether these putative bur...

journal_title：Brain research

authors： Hajós M,Sharp T

更新日期：1996-11-18 00:00:00

abstract：:We examined the in vitro effects of neurotransmitters, high KCl as well as sialic acid-containing compounds (GM1; SC) on transglutaminase (TG) activity in isolated superior cervical ganglia (SCG) one week after denervation or axotomy. Following denervation, TG activity in SCG decreased to 83% of the unoperated control...

journal_title：Brain research

authors： Ando M,Kunii S,Tatematsu T,Nagata Y

更新日期：1993-02-26 00:00:00

abstract：:The distribution and density of noradrenergic (NA) and serotonergic (5-HT) varicosities in the superior olive (SO) and periolivary region (PO) and their relationship to olivocochlear neurons was studied. Antibodies against 5-HT and the NA precursor enzyme dopamine beta-hydroxylase were utilized to examine the density ...

journal_title：Brain research

authors： Woods CI,Azeredo WJ

更新日期：1999-07-31 00:00:00

abstract：:The roles of noradrenergic and serotonergic projections to the hippocampus were investigated with respect to their involvement in the intracranial self-stimulation of this structure. In the first study, 6-hydroxydopamine-induced lesions of the dorsal tegmental noradrenergic bundle, which depleted hippocampal NE by 97%...

journal_title：Brain research

authors： van der Kooy D,Fibiger HC,Phillips AG

更新日期：1977-11-04 00:00:00

abstract：:There is evidence that heme oxygenase plays a role in cellular defense against reactive oxygen species and thereby has neuroprotective effects. We examined the interaction of Neotrofin, a cognitive-enhancing and neuroprotective drug, with the heme oxygenase system. In adult rats, both a single administration or seven ...

journal_title：Brain research

authors： Wang X,Hauptmann N,Taylor E,Foreman M,Khawli LA,Maines MD

更新日期：2003-02-07 00:00:00

abstract：:The hypoxia tracer fluorine-18 fluoromisonidazole ([18F]FMISO) and its tritiated counterpart ([(3)H]FMISO) have been used as markers of potentially salvageable brain (ischemic penumbra) after stroke. In experimental models, the dynamics and half-life of [3H]FMISO allow concurrent histology after 24 h. Our aim was to f...

journal_title：Brain research

authors： Spratt NJ,Donnan GA,Howells DW

更新日期：2009-09-08 00:00:00

abstract：:Lesions of the anterior hypothalamus-medial preoptic area (AH-MPOA) impair courtship and copulatory behavior in male Cnemidophorus inornatus, a sexually reproducing species of whiptail lizard, and male-like pseudosexual behaviors in C. uniparens, an all-female species. These results suggest that, since C. inornatus is...

journal_title：Brain research

authors： Kingston PA,Crews D

更新日期：1994-04-18 00:00:00