Abstract：
:Specific silver impregnation techniques for extracellular amyloid and intraneuronal neurofibrillary changes were used to examine the presubiculum in Alzheimer victims. Extended amyloid clouds in the absence of neurofibrillary changes were noted in the parvopyramidal layer of the presubiculum proper. The corresponding layer in the parasubiculum, in contrast, showed many neurofibrillary tangles and neuropil threads in the absence of amyloid. The transsubicular parvopyramidal layer contained both amyloid deposits and neurofibrillary changes. This severe involvement of all subdivisions of the presubicular region in Alzheimer's disease is considered to impair functions of the Papez circuit.
journal_name
Brain Resjournal_title
Brain researchauthors
Kalus P,Braak H,Braak E,Bohl Jdoi
10.1016/0006-8993(89)90164-9subject
Has Abstractpub_date
1989-08-07 00:00:00pages
198-203issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)90164-9journal_volume
494pub_type
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