The presubicular region in Alzheimer's disease: topography of amyloid deposits and neurofibrillary changes.


:Specific silver impregnation techniques for extracellular amyloid and intraneuronal neurofibrillary changes were used to examine the presubiculum in Alzheimer victims. Extended amyloid clouds in the absence of neurofibrillary changes were noted in the parvopyramidal layer of the presubiculum proper. The corresponding layer in the parasubiculum, in contrast, showed many neurofibrillary tangles and neuropil threads in the absence of amyloid. The transsubicular parvopyramidal layer contained both amyloid deposits and neurofibrillary changes. This severe involvement of all subdivisions of the presubicular region in Alzheimer's disease is considered to impair functions of the Papez circuit.


Brain Res


Brain research


Kalus P,Braak H,Braak E,Bohl J




Has Abstract


1989-08-07 00:00:00














  • Enhancement of forward suppression begins in the ventral cochlear nucleus.

    abstract::A neuron׳s response to a sound can be suppressed by the presentation of a preceding sound. It has been suggested that this suppression is a direct correlate of the psychophysical phenomenon of forward masking, however, forward suppression, as measured in the responses of the auditory nerve, was insufficient to account...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ingham NJ,Itatani N,Bleeck S,Winter IM

    更新日期:2016-05-15 00:00:00

  • Dopamine-like action of nicotine: lack of tolerance and reverse tolerance.

    abstract::Rats with unilateral 6-hydroxydopamine lesions of the substantia nigra became briefly sedated and hypothermic after the acute injection of nicotine s.c. (0.4 or 0.8 mg/kg free base). When nicotine was repeated 5 days per week there was rapid tolerance for the sedation and slower tolerance for the hypothermia and the l...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lapin EP,Maker HS,Sershen H,Hurd Y,Lajtha A

    更新日期:1987-03-31 00:00:00

  • SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia.

    abstract::The aim of the present study was to evaluate p38 MAPK activation following focal stroke and determine whether SB 239063, a novel second generation p38 inhibitor, would directly attenuate early neuronal injury. Following permanent middle cerebral artery occlusion (MCAO), brains were dissected into ischemic and non-isch...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Legos JJ,Erhardt JA,White RF,Lenhard SC,Chandra S,Parsons AA,Tuma RF,Barone FC

    更新日期:2001-02-16 00:00:00

  • Stimulus-response functions in areas with experimentally induced referred muscle pain--a psychophysical study.

    abstract::Few clinical or experimental studies have carried out systematic investigations of cutaneous and deep sensibility in areas with referred muscle pain. Therefore, no clear signs of increased or decreased psychophysical responses to various somatosensory stimuli are found in referred pain areas. In the present study, a t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Graven-Nielsen T,Arendt-Nielsen L,Svensson P,Jensen TS

    更新日期:1997-01-02 00:00:00

  • Colchicine-induced alterations in receptor-stimulated phosphoinositide hydrolysis in the rat hippocampus.

    abstract::Intradentate administration of colchicine has been reported to affect the cholinergic muscarinic system in the hippocampus, causing a reduction in quinclidinylbenzilate binding sites and an increase in choline acetyltransferase activity. Since the cholinergic muscarinic system is coupled to the formation of inositolph...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tandon P,Harry GJ,Tilson HA

    更新日期:1989-01-16 00:00:00

  • Is the effect of somatostatin on muscarinic receptors selective to M1 type?

    abstract::The effect of somatostatin on muscarinic receptors (mAchR) was investigated through saturation experiments of [3H]oxotremorine-M-acetate and oxotremorine/[3H]N-methyl-scopolamine competition experiments. Somatostatin converted oxotremorine high affinity binding sites to low affinity sites in the hippocampus and cerebr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Miyoshi R,Kito S,Mizuno K,Matsubayashi H

    更新日期:1986-07-09 00:00:00

  • Neonatal testosterone treatment increases neuron and synapse numbers in male rat superior cervical ganglion.

    abstract::Neonatal treatment with gonadal steroids has been reported to alter morphological as well as functional development in various regions of the brain and spinal cord. Among the observed alterations are changes in numbers of neurons and in the organization and numbers of synapses. These regions have been found to be sexu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wright LL,Smolen AJ

    更新日期:1983-06-01 00:00:00

  • Aspartate-immunoreactive primary sensory neurons in the mouse trigeminal ganglion.

    abstract::Aspartate-immunoreactivity (ir) was examined in the mouse trigeminal ganglion (TG). The ir was detected in 34% of TG neurons and their cell bodies were of various sizes (mean +/- S.D. = 1,234 +/- 543 microm(2)). A triple immunofluorescence method revealed the co-expression of aspartate with calcitonin gene-related pep...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ichikawa H,Matsuo S,Terayama R,Yamaai T,Sugimoto T

    更新日期:2006-04-12 00:00:00

  • Delayed kindling epileptogenesis and increased neurogenesis in adult rats housed in an enriched environment.

    abstract::Environmental risk factors such as stressful experiences have long been recognized to affect seizure susceptibility, but little attention has been paid to the potential effects of improving housing conditions. In this study, we investigated the influence of an enriched environment on epileptogenesis. Epileptic suscept...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Auvergne R,Leré C,El Bahh B,Arthaud S,Lespinet V,Rougier A,Le Gal La Salle G

    更新日期:2002-11-08 00:00:00

  • Major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons.

    abstract::The two major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (alpha-MeDA) and 3-O-methyl-alpha-methyldopamine (3-O-Me-alpha-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (alpha-MeDOPA and 3-O-Me-alpha-MeDOPA, respecti...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: McCann UD,Ricaurte GA

    更新日期:1991-04-05 00:00:00

  • Substance P receptors in the human spinal cord: decrease in amyotrophic lateral sclerosis.

    abstract::The distribution of substance P receptors was examined by autoradiography at all levels of the human postmortem spinal cord using the ligand [125I]Bolton-Hunter substance P. Adjacent sections were used to localize substance P-like immunoreactivity by a radioimmunohistochemical technique. In the control spinal cord sub...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dietl MM,Sanchez M,Probst A,Palacios JM

    更新日期:1989-03-27 00:00:00

  • Chronic corticotropin-releasing hormone and vasopressin regulate corticosteroid receptors in rat hippocampus and anterior pituitary.

    abstract::Corticotropin-releasing hormone (CRH) and vasopressin (AVP) participate in the endocrine, autonomic, immunological and behavioral response to stress. CRH and AVP receptors are found in hippocampus and anterior pituitary, where mineralocorticoid (MR) and glucocorticoid (GR) receptors are abundant. We investigated the p...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hügin-Flores ME,Steimer T,Schulz P,Vallotton MB,Aubert ML

    更新日期:2003-06-27 00:00:00

  • Effect of alpha 2-adrenoceptor blockade on lithium action in the rat brain.

    abstract::The inhibitory effect of different concentrations of lithium (0.15-10 x 10(-3) M) on cAMP production induced by isoprenaline (1 x 10(-4) M) after the blockade of alpha(2)-adrenoceptors in the rat cerebral cortex was investigated. Low lithium concentrations (0.3-0.6 x 10(-3) M) exerted a significant inhibitory effect a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Laura Cuffi M,Carbonell L,Mármol F,Giménez J,Forn J

    更新日期:2003-12-19 00:00:00

  • GABA-receptor stimulation enhances norepinephrine-induced polyphosphoinositide metabolism in rat hippocampal slices.

    abstract::The effect of gamma-aminobutyric acid (GABA)receptor stimulation on norepinephrine (NE)-induced metabolism of polyphosphoinositides (PIPs) was studied in rat hippocampal slices. Inositol phosphates (IPs), PIPs, and phosphatidic acid were measured. NE induced formation of IPs and phosphatidic acid in a dose-dependent m...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Corradetti R,Ruggiero M,Chiarugi VP,Pepeu G

    更新日期:1987-05-12 00:00:00

  • Brain alpha-tocopherol levels are not altered following ischemia/reperfusion-induced cerebral injury in rats and gerbils.

    abstract::alpha-Tocopherol (alpha-TC) is considered an important endogenous brain antioxidant. The utility of brain alpha-TC levels as an index of in vivo lipid peroxidation has recently been suggested. Therefore, we explored the significance of alpha-TC levels in brains to ischemic insults associated with global or focal cereb...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yue TL,Barone FC,Gu JL,Feuerstein GZ

    更新日期:1993-04-30 00:00:00

  • Sympathetic inhibition and attenuation of spontaneous hypertension by PVN lesions in rats.

    abstract::To determine whether the paraventricular nucleus (PVN) contributes to the development of hypertension in spontaneously hypertensive rats (SHR), we compared cardiovascular responses to ganglionic blockade with hexamethonium or vasopressin antagonism with dPVAVP in sham-operated or PVN lesioned SHR and Wistar-Kyoto rats...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Takeda K,Nakata T,Takesako T,Itoh H,Hirata M,Kawasaki S,Hayashi J,Oguro M,Sasaki S,Nakagawa M

    更新日期:1991-03-15 00:00:00

  • Dose-independent antinociceptive interaction of endogenous ligands at the spinal level.

    abstract::Adenosine, agmatine and kynurenic acid are endogenous ligands acting on different (e.g. adenosine, NMDA, alpha(2)-adrenergic and imidazoline) receptors with a potential role in nociception at the spinal level. Their antinociceptive effects have already been investigated as monotherapy, but only a few studies have repo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kekesi G,Joo G,Csullog E,Peter-Szabo M,Benedek G,Horvath G

    更新日期:2004-12-10 00:00:00

  • Effects of chronic dizocilpine on acute pain and on mRNA expression of neuropeptides and the dopamine and glutamate receptors.

    abstract::The mesocorticolimbic circuitry has been implicated in the pathophysiology of several neuropsychiatric syndromes like chronic pain and addiction. The aim of this study was to evaluate the effects of dizocilpine (MK-801), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, on sensorimotor behaviors and t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Al-Amin HA,Saadé NE,Khani M,Atweh S,Jaber M

    更新日期:2003-08-15 00:00:00

  • The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia.

    abstract::We investigated the protective effect of subchronic treatment of the A2A receptor antagonist, SCH 58261 (0.01 mg/kg, i.p.), administered 5 min, 6 h and 15 h after permanent right middle cerebral artery occlusion (MCAo). Twenty-four hours after ischemia, an extensive pallid area, evaluated by cresyl violet staining, is...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Melani A,Gianfriddo M,Vannucchi MG,Cipriani S,Baraldi PG,Giovannini MG,Pedata F

    更新日期:2006-02-16 00:00:00

  • Two types of medial hypothalamic inhibition of lateral hypothalamic reward.

    abstract::Electrode-implanted rats pressed a lever to self-stimulate a reward mechanism in their lateral hypothalamus (LH) each time with a brief train of pulses. Interdigitation of a medial hypothalamus (MH) train into the ipsilateral LH train inhibited the reward as indicated by a reduced lever pressing rate. Such interdigita...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Porrino LJ,Coons EE,MacGregor B

    更新日期:1983-10-31 00:00:00

  • Melatonin inhibits cyclic AMP and cyclic GMP accumulation in the rat pituitary.

    abstract::Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is sp...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vanĕcek J,Vollrath L

    更新日期:1989-12-25 00:00:00

  • Coexistence of the stigmoid body and estrogen receptor in some neuronal groups involved in rat reproductive functions.

    abstract::Recent immunohistochemical studies have suggested that the forebrain distribution of stigmoid bodies, marked by an antibody against placental aromatase-associated antigen X-P2 (PAX), overlaps with that of the common binding sites of androgen and estrogen. In the present light- and electron-microscopy study the coexist...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nagano M,Shinoda K

    更新日期:1994-01-21 00:00:00

  • Stimulation of the rat dorsal raphe in vivo releases labeled serotonin from the parietal cortex.

    abstract::In vivo release of labeled serotonin ([3H]5-HT) from the parietal cortex was investigated by cortical cup technique and electrical stimulation of midbrain raphe in rats anesthetized with pentobarbital sodium. The spontaneous efflux of tritium from the parietal cortex preload with [3H]5-HT followed a multiphasic expone...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fujiwara H,Uemoto M,Tanaka C

    更新日期:1981-07-20 00:00:00

  • corticofugal regulation of excitatory and inhibitory frequency tuning curves of bat inferior collicular neurons.

    abstract::Corticofugal regulation of excitatory and inhibitory frequency tuning curves (FTCs) of neurons in the central nucleus of bat inferior colliculus (ICc) was studied by electrical stimulation of the primary auditory cortex (AC stimulation) under free field stimulation conditions using a two-tone inhibition paradigm. AC s...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jen PH,Zhang JP

    更新日期:1999-09-11 00:00:00

  • Chronoamperometry in brain slices: quantitative evaluations of in vivo electrochemistry.

    abstract::Practical utilization of in vivo electrochemistry for brain studies has been impeded by difficulties with specificity and quantitative measurements. Studies in brain slices combined with similar data from intact animals have provided important new information on the nature of the electrochemical studies. Using the enz...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schenk JO,Miller E,Rice ME,Adams RN

    更新日期:1983-10-24 00:00:00

  • Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macacafascicularis.

    abstract::Mesenchymal stem cell (MSC) transplantation has been reported to improve neurologic function after ischemic injury. However, the detailed mechanisms by which MSCs promote functional recovery are not fully understood. Interleukin-10 (IL-10) is a well-known anti-inflammatory cytokine with neuroprotective effects with re...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Li J,Zhu H,Liu Y,Li Q,Lu S,Feng M,Xu Y,Huang L,Ma C,An Y,Zhao RC,Wang R,Qin C

    更新日期:2010-06-02 00:00:00

  • REMOVED: Ion changes and signalling in perisynaptic glia.

    abstract::This article has been removed, consistent with Elsevier Policy on Article Withdrawal. Please see ( The Publisher apologizes for any inconvenience this may cause. ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Deitmer JW,Rose CR

    更新日期:2009-10-14 00:00:00

  • The hallucinogen d-lysergic acid diethylamide (d-LSD) induces the immediate-early gene c-Fos in rat forebrain.

    abstract::The hallucinogen d-lysergic acid diethylamide (d-LSD) evokes dramatic somatic and psychological effects. In order to analyze the neural activation induced by this unique psychoactive drug, we tested the hypothesis that expression of the immediate-early gene product c-Fos is induced in specific regions of the rat foreb...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Frankel PS,Cunningham KA

    更新日期:2002-12-27 00:00:00

  • Long-term potentiation in slices from subcortically deafferented hippocampi.

    abstract::Long-term potentiation (LTP) can be initiated in CA1, but not in the dentate, region of slices from rats with bilateral subcortical deafferentation at 8 week survival time. At about one week survival time, LTP is present in the CA1 region of all and also in the dentate of about 50% of slices. The results suggest that ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Czéh G,Horváth Z,Czopf J

    更新日期:1990-06-04 00:00:00

  • Autonomic nerves, mast cells, and amine receptors in human brain vessels. A histochemical and pharmacological study.

    abstract::The studies were performed on operation material from 17- to 63-year-old patients and on fetuses at 19-23 weeks gestational age. Formaldehyde histofluorescence showed the presence of numerous perivascular adrenergic nerves around pial and intracerebral vessels, the carotid system being better supplied than the vertebr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Edvinsson L,Owman C,Sjöberg NO

    更新日期:1976-10-22 00:00:00