Abstract：
:Acetylcholinesterase activity, which may be indicative of cholinergic synapses, has been ultrastructurally localized in the outer plexiform layer of the larval tiger salamander retina using the cholinesterase staining method of Karnovsky and Roots. In the presence of the butyrylcholinesterase inhibitor, ethopropazine, precipitate is localized to discrete 'stain laminae' about 300 nm in their largest dimension and bounded by a 10 nm wide electron-lucent gap. Stain laminae are predominantly found adjacent to horizontal cell axon terminals which were identified by serial section analysis. Stain precipitate has not been found associated with horizontal cell dendrites and in only one case was a lamina found adjacent to a bipolar cell dendrite. Intracellular deposits of cholinesterase stain precipitate were also observed. In some cases, stain is found adjacent to synaptic ribbons in photoreceptor terminals. Likely artifacts appear to have been ruled out by control experiments in which retinas either were not treated with cholinesterase stain or were treated in the presence of the specific acetylcholinesterase inhibitor, BW284C51. Thus, the stain laminae probably result from specific, highly localized areas of acetylcholinesterase activity. The implications of the present study on current theories of cholinergic function in the vertebrate retina are discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Hutchins JB,Polans AS,Werblin FSdoi
10.1016/0006-8993(84)90766-2subject
Has Abstractpub_date
1984-02-06 00:00:00pages
303-15issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(84)90766-2journal_volume
292pub_type
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