Abstract：
:(1) Spreading depression (SD) could be elicited in isolated carp retina by KCI application, the concomitants of which were similar to those described in other vertebrates. (2) The threshold for generating SD was greatly reduced by brief immersion of the retina in low ci-ringer's solutions. The properties of SD waves were almost the same with treated and untreated retinas, except for intervals. (3) Extracellular negative potential shifts during SD, averaging 4.6 mV in amplitude and 27 sec in duration, were recorded in whole retinal layers with the maximum amplitude about at the inner plexiform layer. (4) The PIII potential of the local electroretinogram was virtually unaffected by SD. (5) Both L-and C-type S-potentials could be evoked with increase of 20-40% in amplitude around the peak of slow membrane depolarizations (mean value of maximal amplitude 5.8 mV) during SD in horizontal cells. (6) Increase in spike number was observed in both on-and off-center ganglion cells before and after the spike cessation during SD in the untreated retina. However, the off-discharges, which were a unique response to light in the immersed retina, only decreased during SD.
journal_name
Brain Resjournal_title
Brain researchauthors
Higashida H,Sakakibara M,Mitarai Gdoi
10.1016/0006-8993(77)90498-xsubject
Has Abstractpub_date
1977-01-14 00:00:00pages
67-83issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(77)90498-Xjournal_volume
120pub_type
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