Abstract：
:Congenitally anophthalmic mice (ZRDCT-AN) have circadian rhythms which 'free-run' and are not light modulated. Their rhythms differ from those of controls in: duration of circadian period, length of active phase, and pattern/intensity of activity. Three different populations have been described based upon wheel-running: rhythmic with stable period, rhythmic with unstable period and arrhythmic. Circadian rhythms are generated by neurons in the suprachiasmatic nuclei (SCN) of the hypothalamus. To better understand whether intrinsic properties of SCN neurons differ in anophthalmic and sighted mice, we examined the electrical activity of these neurons in slices, using single unit recordings, ionophoresis and bath perfusion of agonists and antagonists of known SCN neurotransmitters. Lucifer yellow was injected to characterize morphology. In controls, in daytime, units fired at a higher rate (44% at >/=5 Hz) than at night (21% at >/=5 Hz) and with regular interspike intervals versus irregular intervals nocturnally. In anophthalmics four firing patterns were observed as follows: (1) irregular at <5 spikes/s (70% of the total); (2) regular at >/=5 spikes/s; (<10%); (3) irregular bursts (20%); (4) regular bursts (<1%). Most neurons were inhibited by GABA, but a few were excited in controls. Blocking synaptic transmission with low Ca(2+)/high Mg(2+) increased the frequency and regularized the pattern of previously irregular discharges both in anophthalmics and controls. Bicuculline (10(-5) M), a GABA(A) antagonist, had a similar effect. These data suggest that the characteristic irregular firing pattern of anophthalmics, and of controls at night, results from extrinsic, at least in part, GABAergic input.
journal_name
Brain Resjournal_title
Brain researchauthors
Laemle LK,Hori N,Strominger NL,Tan Y,Carpenter DOdoi
10.1016/s0006-8993(02)03272-9subject
Has Abstractpub_date
2002-10-25 00:00:00pages
73-81issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302032729journal_volume
953pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The development of afferent projections to the cerebellum was studied by making small (20 nl) injections of True blue into the cerebella of neonatal rats under general anaesthesia. Neurones in all main precerebellar nuclei were labelled even in rats less than one day old. With the exception of the disappearance of sma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90037-5
更新日期：1988-04-01 00:00:00
abstract：:The anesthetic-sedative barbiturate pentobarbital (PB) and the anticonvulsant barbiturate phenobarbital (PhB) were applied to mammalian spinal cord neurons in primary dissociated cell culture to assess their effects on: (1) postsynaptic GABA-responses; (2) paroxysmal activity produced by the convulsant bicuculline; (3...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91179-3
更新日期：1981-03-23 00:00:00
abstract：:Glucose transporter (GLUT) 4 plays an important role in insulin-induced glucose uptake in skeletal muscle and white adipose tissue. Although GLUT4 is abundant in the hypothalamus as well as in these peripheral tissues, little is known about the role of GLUT4 in the hypothalamus. In this study, we examined the subcellu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.079
更新日期：2005-07-05 00:00:00
abstract：:Dopaminergic psychostimulants produce behavioral responses of greater magnitude with repeated, intermittent administration, than a single, acute dose, a phenomenon known as 'sensitization'. Alterations in regional neuronal activity produced by quinpirole, a D(2)/D(3) agonist, in quinpirole-naive and quinpirole-sensiti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04115-x
更新日期：2003-02-28 00:00:00
abstract：:In the present study we investigated the correlation between radiation-induced metabolic and histopathological changes in the brain under experimental conditions. Adult male Wistar rats received fractionated whole-brain irradiation (fWBI) with a total dose of 40 Gy administered in 5 fractions (dose 8 Gy per fraction) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.12.022
更新日期：2019-04-01 00:00:00
abstract：:The cognitive reserve hypothesis proposes that the brain actively attempts to cope with age-related changes by using pre-existing cognitive networks (neural reserve) or enlisting compensatory processes (neural compensation). In a context of visual selective attention, the current study compared task-related activation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.061
更新日期：2012-05-15 00:00:00
abstract：:Based on the fact that several recent reports have indicated that non-immunosuppressive immunophilin ligands (IPLs) can activate neurite outgrowth or nerve regeneration, we investigated the neurotrophic factor-activating abilities of IPLs in vivo in order to clarify the molecular basis of neurotrophic-like activity. B...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02434-x
更新日期：2003-04-25 00:00:00
abstract：:Zinc ions seem to be important to several neurological functions and have been connected to the pathophysiology of epilepsy, neuronal cell death after seizure or stroke, and Alzheimer's disease. Both epilepsy and Alzheimer's disease are clinical conditions believed to involve the olfactory bulb. The mammalian olfactor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03544-8
更新日期：2002-11-29 00:00:00
abstract：:This study was performed to investigate the mechanism how amantadine increases the extracellular dopamine (DA) levels in the striatum in vivo. Local application of amantadine (1 mM, 40 min) to the striatum through the dialysis membrane significantly increased the extracellular DA levels. Coadministration of nomifensin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90821-4
更新日期：1994-10-31 00:00:00
abstract：:The induction of gene expression has been correlated with long-lasting neuronal plasticity and long-term memory (LTM) formation. The fast activation of constitutive transcription factors by signaling mechanisms is thought to be the link between synaptic events and gene expression. However, only one constitutive transc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02358-6
更新日期：2000-02-14 00:00:00
abstract：:The neurotoxicity of ionomycin, a Ca2+ ionophore, was investigated in cultured cortical neurons from embryonic rats. While about 90% of neurons survived 2 h after exposure to ionomycin, the surviving neurons had decreased by about 30 to 40% at 16 h. Both RNA and protein synthesis inhibitors blocked this neurotoxicity....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90317-4
更新日期：1994-07-25 00:00:00
abstract：:In anesthetized, artificially ventilated cats, pretreated with the muscarinic antagonist scopolamine, the effect of naloxone on the efficacy of nicotinic transmission in the superior cervical ganglion was used as a test of endogenous opioid release by the preganglionic axons. The cervical sympathetic trunk (CST) was s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91102-7
更新日期：1991-05-10 00:00:00
abstract：:This review provides a snapshot of the current ethical issues related to research with human brain organoids. The issues fall into the following main themes: research oversight; human biomaterials procurement and donor consent; translational delivery; animal research; and organoid consciousness and moral status. Each ...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2020.146653
更新日期：2020-04-01 00:00:00
abstract：:We have previously demonstrated that Fos immunoreactivity can be stimulated by KCl, forskolin or glutamate in cultured tyrosine hydroxylase-immunoreactive (TH-ir) hypothalamic neurons. The present study was performed to determine whether agents that regulate dopaminergic activity, particularly D1 and D2 receptor agoni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90711-0
更新日期：1994-07-18 00:00:00
abstract：:Nodes of Ranvier in the central nervous system in mammals are characterized by the presence of perinodal astrocytic processes. This study examines the association between processes of radial glia and the axolemma at nodes of Ranvier in the spinal cord of the mature axolotl, an animal in which radial glia represent a l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90595-m
更新日期：1991-05-17 00:00:00
abstract：:Neurons from many brainstem nuclei involved in respiratory control increase their firing rate in response to acidosis in vitro, suggesting that they are central chemoreceptors. This property has been considered to be either unique to neurons involved in respiratory control, or at least very unusual for non-respiratory...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02033-3
更新日期：2000-03-31 00:00:00
abstract：:This ERP study explores the brain's response to the manipulation of motor compatibility in action-related language. In Experiment 1 participants read sentences in which a protagonist performed two different manual actions either simultaneously or consecutively (e.g. While/after cleaning the wound he unrolled the banda...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.06.020
更新日期：2013-08-14 00:00:00
abstract：:An isoindolin-1-one derivate, JM-1232(-), was recently developed as a sedative and hypnotic agent with a strong affinity for the central benzodiazepine binding site of gamma-aminobutyric acid(A) (GABA(A)) receptors. The purpose of this study was to examine the effects of JM-1232(-) on the cardiovascular and sympatheti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.092
更新日期：2009-12-01 00:00:00
abstract：:To understand the functional organization of the piriform cortex (PC), the axon collaterals of three pyramidal cells in layer IIb of the anterior PC and one pyramidal cell in layer IIb of the posterior PC were labeled and quantitatively analyzed by intracellular biocytin injection in the guinea pig. Single pyramidal c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.085
更新日期：2004-11-05 00:00:00
abstract：:Double-pulse stimulation of the perforant path input to the dentate gyrus was used in the following experiments to produce paired pulse depression in that site. This effect provided an estimate of GABA-mediated recurrent inhibition. The depression was enhanced by drugs that facilitate or mimic GABA action and attenuat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90909-5
更新日期：1983-10-24 00:00:00
abstract：:The neuroprotection research in the last 2 decades has witnessed a growing interest in the functions of estrogens as neuroprotectants against neurodegenerative diseases including stroke. The neuroprotective action of estrogens has been well demonstrated in both in vitro and in vivo models of ischemic stroke. However, ...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2013.01.023
更新日期：2013-06-13 00:00:00
abstract：:It has been previously observed that taurine inhibits PKC-activated phosphorylation of specific proteins including a approximately 20k Mr protein in rat cortical synaptosomes. In the present study, the mechanism of the above effects of taurine were investigated. In an intrasynaptosomal cytosol fraction obtained by sub...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90234-m
更新日期：1991-07-05 00:00:00
abstract：:Somatosensory information has been thought to ascend from the spinal cord to limbic areas of the telencephalon through indirect, multisynaptic pathways. We now report that injections of Fluoro-gold into either the nucleus accumbens or the septal nuclei labeled hundreds of neurons in the spinal cord. These and our rece...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90981-5
更新日期：1989-09-11 00:00:00
abstract：:The effects of diazepam, nitrazepam, clonazepam, and Ro5-4864 on transient (type I) and long-lasting (type II) calcium channels associated with low-affinity benzodiazepine receptors were investigated using the whole-cell patch-clamp technique. Clonazepam (100 microM), a specific agonist for the central-type benzodiaze...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90991-u
更新日期：1993-03-26 00:00:00
abstract：:Elevation of [K+]o for 30 s from 4 to 120 mM produced a fast and reversible depolarization and transient increase in [Ca2+]i in fura-2 loaded Retzius cells of the leech. The protein phosphatase inhibitor, okadaic acid, significantly slowed the return of [Ca2+]i toward baseline without affecting the amplitude of depola...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91800-7
更新日期：1994-07-11 00:00:00
abstract：:The protective effect of mild hypothermia was studied in rodent models of both permanent and transient focal cerebral ischemia. In Expt. 1, Wistar rats were exposed to 6 h permanent ischemia by bilateral occlusion of both common carotid arteries and right middle cerebral artery. In Expt. 2, animals were exposed to 3 h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91428-h
更新日期：1992-07-31 00:00:00
abstract：:Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O(2)) or intermittent hypoxia (IH; 10% and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.063
更新日期：2006-06-22 00:00:00
abstract：:The object of this study was to quantify and compare the degree of control monkeys may assert over firing patterns of normal and epileptic neurons. Thirty-seven epileptic and 70 normal neurons were studied in detail. The operant task was for the monkey to generate specified consecutive interspike intervals (ISI). The ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90884-3
更新日期：1978-08-04 00:00:00
abstract：:Two D-amino acid substitution angiotensin analogues were compared against native angiotensin II (AII) and angiotensin III (AIII) for their resistance to brain tissue-induced degradation and for pressor potency when intracerebroventricularly (i.c.v.) infused in Sprague-Dawley rats. The in vitro results indicate that [D...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90428-e
更新日期：1990-04-23 00:00:00
abstract：:Hippocampal long-term potentiation (LTP) is considered as a cellular model of memory formation. Specific, electrical weak tetanization of distinct afferents such as the medial perforant path results in a short-lasting, protein synthesis-independent early-LTP (up to 4 h) within the dentate gyrus. A stronger tetanizatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.03.055
更新日期：2009-06-01 00:00:00
