Metabolic and histopathological changes in the brain and plasma of rats exposed to fractionated whole-brain irradiation.

abstract：:This paper describes carbon fibre electrodes that can simultaneously monitor changes in ascorbic acid, dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in vivo in the rat striatum using differential pulse voltammetry. The separation between DOPAC and 5HIAA oxidation is...

journal_title：Brain research

authors： Crespi F,Sharp T,Maidment NT,Marsden CA

更新日期：1984-11-19 00:00:00

abstract：:Apoptosis has been shown to be induced by some pathological stimuli. MPP+ is a neurotoxin and an inducer of parkinsonism. When SH-SY5Y cells, human neuroblastoma cell line, were treated with MPP+, cell death estimated by lactate dehydrogenase (LDH) leakage assay occurred. The cell death was associated with the DNA fra...

journal_title：Brain research

authors： Itano Y,Nomura Y

更新日期：1995-12-18 00:00:00

abstract：:Intradentate administration of colchicine has been reported to affect the cholinergic muscarinic system in the hippocampus, causing a reduction in quinclidinylbenzilate binding sites and an increase in choline acetyltransferase activity. Since the cholinergic muscarinic system is coupled to the formation of inositolph...

journal_title：Brain research

authors： Tandon P,Harry GJ,Tilson HA

更新日期：1989-01-16 00:00:00

abstract：:The existence of multiple brain melanocortin receptor types has been postulated, based on the complex pharmacology of intracerebrally administered melanocortin (melanocyte-stimulating hormone-related) peptides. In this study, this hypothesis was tested by determining whether different brain melanocortin receptor popul...

journal_title：Brain research

authors： Tatro JB,Entwistle ML

更新日期：1994-01-28 00:00:00

abstract：:A 'new' and orderly representation of the body surface was found in the cerebral cortex of the cat. This somatotopic map was located in the anterior ectosylvian sulcus (AES), an area known to represent several modalities, but believed to be distinguished from primary sensory cortex by its lack of sensory topographies....

journal_title：Brain research

authors： Clemo HR,Stein BE

更新日期：1982-03-04 00:00:00

abstract：:The parafascicular thalamic nucleus (nPf) is a critical relay in the ascending system that mediates motor control in the central nervous system (CNS). Yet, little is known about whether or not the nPf is involved in the development of morphine dependence and withdrawal. In the present study, kainic acid was used to ch...

journal_title：Brain research

authors： Xiao H,Zhai DX,Yan BB,Wang JH,Xu WS,Wang GY,Bai SS,Kong QF,Sun B,Wang DD,Jin DJ,Li HL

更新日期：2009-05-19 00:00:00

abstract：:Converging evidence implicates alterations in multiple signaling pathways in the etiology of schizophrenia. Previously, these studies were limited to the analysis of one or a few phosphoproteins at a time. Here, we use a novel kinase array platform to simultaneously investigate the convergence of multiple signaling ca...

journal_title：Brain research

authors： McGuire JL,Hammond JH,Yates SD,Chen D,Haroutunian V,Meador-Woodruff JH,McCullumsmith RE

更新日期：2014-06-03 00:00:00

abstract：:Neonatal MK-801 treatment from postnatal day 8-19 leads to long-term effects on brain function, suggesting that exposure to this drug leads to the development of a brain with immature network properties. One aspect of this hypothesis, that the NMDA receptors preserve their immature state after the treatment, has been ...

journal_title：Brain research

authors： Gorter JA,Brady RJ

更新日期：1994-11-28 00:00:00

abstract：:Epileptiform activity induced by 4-AP in hippocampal area CA1 is characterised by short recurrent discharges. These are occasionally superimposed by slow field potential (fp) shifts. Simultaneous recordings of fps and [K(+)](o) in area CA1 and temporal cortex showed a slow fp shift in both regions, but associated rise...

journal_title：Brain research

authors： Breustedt J,Gloveli T,Heinemann U

更新日期：2002-11-22 00:00:00

abstract：:Adult male rats, intact (N) or with complete (CHD), anterior (AHD), or posterior (PHD) hypothalamic deafferentations were bilaterally adrenalectomized. At 3, 6, 12 and 20 days post-adrenalectomy they were decapitated and trunk blood was collected for ACTH determinations. In N rats, ACTH markedly elevated up to 850 pg/...

journal_title：Brain research

authors： Weidenfeld J,Siegel RA,Conforti N,Chowers I,Feldman S

更新日期：1984-11-26 00:00:00

abstract：:The choroid plexus epithelium constitutes the structural basis of the blood-cerebrospinal fluid barrier. We previously demonstrated that Streptococcus suis (S. suis), a relevant cause of bacterial meningitis in pigs and humans, affects porcine choroid plexus epithelial cell (PCPEC) barrier function and integrity. We n...

journal_title：Brain research

authors： Tenenbaum T,Essmann F,Adam R,Seibt A,Jänicke RU,Novotny GE,Galla HJ,Schroten H

更新日期：2006-07-19 00:00:00

abstract：:Unilateral injections of 6-hydroxydopamine into the lateral hypothalamus or ventral tegmental area that damage extensively the mesotelencephalic dopaminergic projection result in significant hemispheric asymmetries in autoradiographic labeling after [14C]2-deoxy-D-glucose (2DG) administration. The incorporation of thi...

journal_title：Brain research

authors： Kozlowski MR,Marshall JF

更新日期：1980-09-15 00:00:00

abstract：:To determine the effect of thyroid hormones (TH) on cerebral tissue malondialdehyde (MDA) content and accumulation of MDA-bound proteins, hyperthyroid rats and hypothyroid rats were compared to euthyroid controls. Hyperthyroidism was induced by daily injection of l-3,5, 3'-triiodothyronine (15 ug (100 g)-1) intraperit...

journal_title：Brain research

authors： Chehade J,Kim J,Pinnas JL,Mooradian AD

更新日期：1999-05-22 00:00:00

abstract：:Intracerebral injections of 6-hydroxydopamine (6-OHDA) which produce deficits in locomotor behaviour and motor performance cause localized accumulation of monoamines as well as depletion of central catecholamines (CA). To determine whether the localized increases in monoamines could be contributing to the behavioural ...

journal_title：Brain research

authors： Willis GL,Smith GC,McGrath BP

更新日期：1983-05-05 00:00:00

abstract：:Inbred mouse strains differed significantly in sensitivity to convulsions induced by 9 convulsant drugs administered using a timed infusion procedure. Some strains (e.g. BALB/cJ, A/J) were generally seizure-susceptible, while some were generally seizure resistant (e.g. C57BL/6J, SWR/J). However, the overall pattern of...

journal_title：Brain research

authors： Kosobud AE,Crabbe JC

更新日期：1990-08-27 00:00:00

abstract：:Experiments were undertaken to compare effects of the NMDA and non-NMDA receptor antagonists, AP5 (40 microM) and NBQX (10 microM), on glutamate-induced firing in supraoptic oxytocin (OT) and vasopressin (VP) neurones in vitro. In putative OT neurones NBQX caused a significantly greater reduction in firing than AP5, w...

journal_title：Brain research

authors： Richardson CM,Wakerley JB

更新日期：1997-08-29 00:00:00

abstract：:How does attention interact with learning? Kruschke [Kruschke, J.K. (2001). Toward a unified Model of Attention in Associative Learning. J. Math. Psychol. 45, 812-863.] proposed a model (EXIT) that captures Mackintosh's [Mackintosh, N.J. (1975). A theory of attention: Variations in the associability of stimuli with re...

journal_title：Brain research

authors： Pauli WM,O'Reilly RC

更新日期：2008-04-02 00:00:00

abstract：:Behavioral responses to light tactile stimulation of the skin of the head of axolotls were variable in occurrence but were of a constant pattern. Retraction of the eyes and gills followed stimulation of dorsal but not ventral skin. Ventral skin yielded lowering of the head. Touching near the lips caused turning of the...

journal_title：Brain research

authors： Griersmith BT,Mark RF

更新日期：1981-09-01 00:00:00

abstract：:Transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-beta 1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-beta 1 on neurite regeneration following a...

journal_title：Brain research

authors： Abe K,Chu PJ,Ishihara A,Saito H

更新日期：1996-06-03 00:00:00

abstract：:Relative preservation of dopaminergic axons in patches and a subcallosal layer was observed in the dorsal, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-OHDA), a neurotoxin selective for catecholaminergic neurons. Since calcium binding proteins are reported to provide neurop...

journal_title：Brain research

authors： Tsuboi K,Kimber TA,Shults CW

更新日期：2000-06-02 00:00:00

abstract：:Physical activity has been proposed as a behavior intervention that promotes mental health and some of the benefits induced by exercise have been related to the glutamatergic system. Indeed, glutamate is the most abundant excitatory neurotransmitter in brain. Thus, we evaluated if voluntary exercise in mice could modu...

journal_title：Brain research

authors： Dietrich MO,Mantese CE,Porciuncula LO,Ghisleni G,Vinade L,Souza DO,Portela LV

更新日期：2005-12-14 00:00:00

abstract：:Murine brain cells differentiated for 19 days in culture before treatment for 5 days with 10 microM diazepam. Radioligand binding to the benzodiazepine receptors on membranes obtained from these cultures was determined by the filtration assay method. Decreased binding was observed in the membranes from treated culture...

journal_title：Brain research

authors： Prezioso PJ,Neale JH

更新日期：1983-12-12 00:00:00

abstract：:Abrupt withdrawal from chronic alcohol exposure can produce convulsions that are likely due to ethanol (EtOH) neuroadaptations. While significant efforts have focused on elucidating dependence mechanisms, the alterations contributing to EtOH withdrawal severity are less well characterized. The present studies examined...

journal_title：Brain research

authors： Beadles-Bohling AS,Wiren KM

更新日期：2005-06-07 00:00:00

abstract：:Unanesthetized adult male rats with indwelling right atrial cannulae were used in the majority of experiments. Morphine (MOR, 3.0 mg/kg) caused a large but transient increase in both GH and PRL levels, which could be prevented with naloxone. Disruption of central noradrenergic function with diethyldithiocarbamate (400...

journal_title：Brain research

authors： Koenig J,Mayfield MA,Coppings RJ,McCann SM,Krulich L

更新日期：1980-09-22 00:00:00

abstract：:Nitric oxide (NO) is a putative neuronal messenger in the olfactory epithelium. We analysed the electrical responses of rat olfactory receptor neurones to NO stimulation in the whole-cell patch clamp mode and found that NO activates the cyclic nucleotide-gated conductance, independent from cyclic GMP. As NO may also o...

journal_title：Brain research

authors： Schmachtenberg O,Diaz J,Bacigalupo J

更新日期：2003-08-01 00:00:00

abstract：:The ability to recognize previous experience depends on two neurocognitive processes, familiarity, fast-acting and relatively automatic, and recollection, slower-acting and more effortful. Familiarity appears to mature relatively early in development and is maintained with aging, whereas recollection shows protracted ...

journal_title：Brain research

authors： Friedman D,de Chastelaine M,Nessler D,Malcolm B

更新日期：2010-01-15 00:00:00

abstract：:Microglial cyclo-oxygenase (COX) expression is considered to be important in the pathogenesis of Alzheimer's disease (AD) and, therefore, constitutes a key target for therapeutic intervention. We investigated the influence of AD plaque associated factors on COX-1 and COX-2 expression and activity in adult human microg...

journal_title：Brain research

authors： Hoozemans JJ,Veerhuis R,Janssen I,van Elk EJ,Rozemuller AJ,Eikelenboom P

更新日期：2002-10-04 00:00:00

abstract：:Hypoxia preconditioning states that a sublethal hypoxia period will afford neuroprotection against a second harmful event. In our experiments, we carried out a procedure for the development of hypoxia preconditioning in adult male Wistar rats using hypoxic exposure (9% O(2); 91% N(2)) for 1 h. The protection against p...

journal_title：Brain research

authors： Rauca C,Zerbe R,Jantze H,Krug M

更新日期：2000-06-16 00:00:00

abstract：:The incidence of amyotrophic lateral sclerosis (ALS) is higher among men than women but rises in women after the menopause. Estrogens may play a protective role. Treatment with estrogens has been shown to be neuroprotective in models of several neurodegenerative diseases. We therefore determined the effect of ovariect...

journal_title：Brain research

authors： Groeneveld GJ,Van Muiswinkel FL,Sturkenboom JM,Wokke JH,Bär PR,Van den Berg LH

更新日期：2004-09-17 00:00:00

abstract：:The effects of GM1 ganglioside (30 mg/kg i.p.) administration for 22 days on choline acetyltransferase (ChAT) activity and noradrenaline (NA) levels in the cerebral cortex and on the acquisition of active and passive avoidance-conditioned responses were investigated in both sham-operated rats and in rats with a unilat...

journal_title：Brain research

authors： Casamenti F,Bracco L,Bartolini L,Pepeu G

更新日期：1985-07-08 00:00:00