Abstract：
:Intracerebral injections of 6-hydroxydopamine (6-OHDA) which produce deficits in locomotor behaviour and motor performance cause localized accumulation of monoamines as well as depletion of central catecholamines (CA). To determine whether the localized increases in monoamines could be contributing to the behavioural deficits seen after intracerebral 6-OHDA injection, the behavioural and biochemical effects of peripherally administered L-DOPA were compared to those which occurred after central injections of 6-OHDA. Forty-five minutes after the injection of 40 mg/kg of L-DOPA, in animals pretreated with 50 mg/kg of R04-4602, the ability to step down, to retract a limb and to ambulate were significantly impaired. Locomotor behaviour and body temperature of L-DOPA-injected animals were similar to those displayed by animals receiving intracerebral injections of 6-OHDA. Fluorescent histochemical and biochemical assessment of diencephalic and telencephalic CA revealed that depletion of CA was not related to the severity of the motor deficits which occurred, but that increased diencephalic CA were present in impaired animals injected with either 6-OHDA or L-DOPA. These findings support the contention that increased CA in degenerating hypothalamic neurones may contribute to behavioural deficits seen after the injection of 6-OHDA.
journal_name
Brain Resjournal_title
Brain researchauthors
Willis GL,Smith GC,McGrath BPdoi
10.1016/0006-8993(83)90659-5subject
Has Abstractpub_date
1983-05-05 00:00:00pages
279-86issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(83)90659-5journal_volume
266pub_type
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